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Microfluidic Spinning of the Fibrous Alginate Scaffolds for Modulation of the Degradation Profile

Mun CH, Hwang JY, Lee SH

In tissue engineering, alginate has been an attractive material due to its biocompatibility and ability to form hydrogels, unless its uncontrollable degradation could be an undesirable feature. Here, we developed...
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Gene Therapy for Bone Tissue Engineering

Kim YD, Pofali P, Park TE, Singh B, Cho K, Maharjan S, Dandekar P, Jain R, Choi YJ, Arote R, Cho CS

Gene therapy holds a great promise and has been extensively investigated to improve bone formation and regeneration therapies in bone tissue engineering. A variety of osteogenic genes can be delivered...
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Synthetic Hydrogels with Stiffness Gradients for Durotaxis Study and Tissue Engineering Scaffolds

Whang M, Kim J

Migration of cells along the right direction is of paramount importance in a number of in vivo circumstances such as immune response, embryonic developments, morphogenesis, and healing of wounds and...
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Substance P Modulates Properties of Normal and Diabetic Dermal Fibroblasts

Jung N, Yu J, Um J, Dubon MJ, Park KS

Dermal fibroblasts play essential roles in wound healing. However, they lose their normal regenerative functions under certain pathologic conditions such as in chronic diabetic wounds. Here, we show that substance...
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Substance P and Thiorphan Synergically Enhance Angiogenesis in Wound Healing

Um J, Yu J, Dubon MJ, Park KS

Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is important for proper tissue repair. It was reported that substance P (SP) accelerates wound...
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Repair of Partial Thickness Cartilage Defects Using Cartilage Extracellular Matrix Membrane-Based Chondrocyte Delivery System in Human Ex Vivo Model

Park DY, Min BH, Lee HJ, Kim YJ, Choi BH

Treatment options for partial thickness cartilage defects are limited. The purpose of this study was to evaluate the efficacy of the chondrocyte-seeded cartilage extracellular matrix membrane in repairing partial thickness...
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Comparative Study of BMP-2 Alone and Combined with VEGF Carried by Hydrogel for Maxillary Alveolar Bone Regeneration

Kim SK, Cho TH, Han JJ, Kim IS, Park Y, Hwang SJ

The effect of vascular endothelial growth factor (VEGF) combined with bone morphogenetic protein-2 (BMP-2) for bone regeneration is still controversial as to whether or not VEGF has a synergistic or...
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Osseointegration of Magnesium-Incorporated Sand-Blasted Acid-Etched Implant in the Dog Mandible: Resonance Frequency Measurements and Histomorphometric Analysis

Song WW, Heo JH, Lee JH, Park YM, Kim YD

The aim of this pilot study was to investigate the bone responses of novel magnesium (Mg)–incorporated sand-blasted and acid-etched (SLA) titanium (Ti) implant in an experimental animal model. Novel Mg-incorporated...
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Expression of Tenocyte Lineage-Related Factors from Tonsil-Derived Mesenchymal Stem Cells

Yu Y, Lee SY, Yang EJ, Kim HY, Jo I, Shin SJ

Human palatine tonsil-derived mesenchymal stem cells (TMSCs) are known to be a new source of progenitor cells. Using waste tissue after tonsillectomy as a cell provider can be the biggest...
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Autologous Bone Marrow Mesenchymal Cell Induced Chondrogenesis for the Treatment of Osteoarthritis of Knee

Huh SW, Shetty AA, Kim JM, Cho ML, Kim SA, Yang S, Kim YJ, Javaregowda PK, Choi NY, Kang J, Kim SJ

Healthy and high quality of life has become the main issue with increasing human life span. Many biological treatments for osteoarthritis of the knee have been tried with limited success....
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