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In Situ Cross-Linkable Hydrogels as a Dynamic Matrix for Tissue Regenerative Medicine

Park KM, Park KD

BACKGROUND: Polymeric hydrogels are extensively used as promising biomaterials in a broad range of biomedical applications, including tissue engineering, regenerative medicine, and drug delivery. These materials have advantages such as...
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Injectable Hydrogels for Regenerative Medicine

Kim BS, Cho CS

No abstract available.
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Biopolymeric In Situ Hydrogels for Tissue Engineering and Bioimaging Applications

Sontyana A, Mathew AP, Cho KH, Uthaman S, Park IK

BACKGROUND: Biopolymeric in situ hydrogels play a crucial role in the regenerative repair and replacement of infected or injured tissue. They possess excellent biodegradability and biocompatibility in the biological system,...
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Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications

Gopinathan J, Noh I

BACKGROUND: The tissue engineering and regenerative medicine approach require biomaterials which are biocompatible, easily reproducible in less time, biodegradable and should be able to generate complex three-dimensional (3D) structures to...
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Electrostatically Interactive Injectable Hydrogels for Drug Delivery

Seo JY, Lee B, Kang TW, Noh JH, Kim MJ, Ji YB, Ju HJ, Min BH, Kim MS

BACKGROUND: Several injectable hydrogels have been developed extensively for a broad range of biomedical applications. Injectable hydrogels forming in situ through the change in external stimuli have the distinct properties...
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Injectable Biomaterials in Plastic and Reconstructive Surgery: A Review of the Current Status

Cho KH, Uthaman S, Park IK, Cho CS

BACKGROUND: Injectable biomaterials have attracted increasing attention for volume restoration and tissue regeneration. The main aim of this review is to discuss the current status of the injectable biomaterials for...
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Characterization of Human Fetal Cartilage Progenitor Cells During Long-Term Expansion in a Xeno-Free Medium

Kim HR, Kim J, Park SR, Min BH, Choi BH

BACKGROUND: Stem cell therapy requires a serum-free and/or chemically-defined medium for commercialization, but it is difficult to find one that supports long-term expansion of cells without compromising their stemness, particularly...
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Full Thickness Skin Expansion ex vivo in a Newly Developed Reactor and Evaluation of Auto-Grafting Efficiency of the Expanded Skin Using Yucatan Pig Model

Huh MI, Yi1 SJ, Lee KP, Kim HK, An SH, Kim DB, Ryu RH, Kim JS, Lim JO

BACKGROUND: Skin grafts are required in numerous clinical procedures, such as reconstruction after skin removal and correction of contracture or scarring after severe skin loss caused by burns, accidents, and...
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Hydroxyapatite Nanorod-Modified Sand Blasted Titanium Disk for Endosseous Dental Implant Applications

Park SJ, Kim BS, Gupta KC, Lee DY, Kang IK

BACKGROUND: Sand blasted titanium (Ti) is commonly used in designing endosseous dental implants due to its biocompatibility and ability to form bonds with bone tissues. However, titanium implants do not...
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Polypeptide Thermogels as Three-Dimensional Scaffolds for Cells

Patel M, Park S, Lee HJ, Jeong B

BACKGROUND: Thermogel is an aqueous solution that exhibits a sol-to-gel transition as the temperature increases. Stem cells, growth factors, and differentiating factors can be incorporated in situ in the matrix...
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The Effect of Fibronectin-Immobilized Microgrooved Titanium Substrata on Cell Proliferation and Expression of Genes and Proteins in Human Gingival Fibroblasts

Kim EC, Lee DY, Lee MH, Lee HJ, Kim KH, Leesungbok R, Ahn SJ, Park SJ, Yoon JH, Jee YJ, Lee SC, Lee SW

BACKGROUND: We aimed to determine the effect of fibronectin (FN)-immobilized microgrooved titanium (Ti) on human gingival fibroblast proliferation, gene expression and protein expression. METHODS: Photolithography was used to fabricate the microgrooved...
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Cellular Response of Anodized Titanium Surface by Poly(Lactide-co-Glycolide)/Bone Morphogenic Protein-2

Lee SY, Koak JY, Kim SK, Heo SJ

BACKGROUND: The purpose of this study is to examine physical characteristics of and initial biological properties to anodized titanium treated with poly(D,L-lactide-co-glycolide) (PLG) mixed with recombinant human bone morphogenic protein-2...
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Optimal Stem Cell Transporting Conditions to Maintain Cell Viability and Characteristics

Yu NH, Chun SY, Ha YS, Kim HT, Kim DH, Kim J, Chung JW, Lee JN, Song PH, Yoo ES, Kim BS, Kwon TG

BACKGROUND: The preservation of stem cell viability and characteristics during cell transport from the bench to patients can significantly affect the success of cell therapy. Factors such as suspending medium,...
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Combination of Mesenchymal Stem Cells, Cartilage Pellet and Bioscaffold Supported Cartilage Regeneration of a Full Thickness Articular Surface Defect in Rabbits

Abbas M, Alkaff M, Jilani A, Alsehli H, Damiati L, Kotb M, Abdelwahed M, Alghamdi F, Kalamegam

BACKGROUND: Mesenchymal stem cells (MSCs) and/or biological scaffolds have been used to regenerate articular cartilage with variable success. In the present study we evaluated cartilage regeneration using a combination of...
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