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Percutaneous Thrombin Injection for the Treatment of Post-Procedural Iatrogenic Pseudoaneurysms

Park S, Shin JH, Ko GY, Gwon DI, Ko HK, Kim JW

PURPOSE: To report our clinical experience of thrombin injection for iatrogenic pseudoaneurysms of peripheral arteries with or without balloon dilatation and coil embolization as adjunctive techniques. MATERIALS AND METHODS: A total...
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A Case of Intraoperative Anaphylaxis Caused by Bovine-Derived Thrombin

Park HJ, Suk KS, Park JW

Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and...
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Benefits of Thromboelastography and Thrombin Generation Assay for Bleeding Prediction in Patients With Thrombocytopenia or Hematologic Malignancies

Kim SY, Gu JY, Yoo HJ, Kim JE, Jang S, Choe S, Koh Y, Kim I, Kim HK

BACKGROUND: Thromboelastography (TEG) provides comprehensive information on the whole blood clot formation phases, whereas thrombin generation assay (TGA) reveals the endogenous thrombin levels in plasma. We investigated the potential significance...
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Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System

Leem E, Jeong KH, Won SY, Shin WH, Kim SR

Although accumulating evidence suggests that microglia-mediated neuroinflammation may be crucial for the initiation and progression of Parkinson's disease (PD), and that the control of neuroinflammation may be a useful strategy...
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Spontaneous Pseudoaneurysm of the Uterine Artery during Pregnancy Treated by Direct Thrombin Injection: A Case Report

Hong JH, Kim SH, Kim YH

Pseudoaneurysm of uterine artery during pregnancy is a very rare disease. It is mostly associated with uterine artery injury, usually occurring after proceeding conditions such as history of gynecologic operation...
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Anaphylaxis to topical bovine thrombin used for hemostasis during surgery for herniated nucleus pulposus: A case report

Kim H, Lee D, Lee H, Han J

Anaphylaxis is a type I allergic reaction and its clinical features occur after re-exposure to the same allergen. Numerous types of drugs can cause anaphylaxis during general anesthesia. Topical bovine...
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Risk and Effectiveness of Using Thrombin in Microvascular Free Tissue Transfer

Ki SH, Kim HJ

  • KMID: 2047984
  • Arch Reconstr Microsurg.
  • 2014 May;23(1):1-7.
PURPOSE: Recent studies have reported on application of fibrin glue composed of fibrinogen and thrombin to nerve anastomosis, which can be another candidate for vessel anastomosis. However, no research regarding...
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Balloon-Assisted Ultrasound-Guided Thrombin Injection of a Pseudoaneurysm in the Posterior Tibial Artery: A Case Report

Lee TK, Jeon YS, Hong KC, Cho SG, Kim E

An ultrasound-guided direct injection of thrombin is currently the first choice of treatment for the postcatheterization pseudoaneurysm, mainly in the femoral artery. A pseudoaneurysm in the posterior tibial artery is...
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Percutaneous ultrasound-guided thrombin injection is effective even in infants with external iliac artery pseudoaneurysms

Cho MJ, Jeon UB, Choo KS, Lee HD

Iatrogenic pseudoaneurysms are extremely rare in children. Conventional management of pseudoaneurysms in adults has included surgical repair, ultrasound-guided compression, and more recently, endovascular embolization. However, in infants and children, there...
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Percutaneous Thrombin Injection with Balloon Occlusion for the Treatment of a Femoral Artery Pseudoaneurysm

Kim BS, Shin JH, Kim YS, Lee Y, Kim J, Park HC, Choi SI

  • KMID: 2128471
  • Korean J Med.
  • 2014 Apr;86(4):484-488.
Femoral artery pseudoaneurysm (FAP) is an uncommon but potentially serious vascular complication that may develop after cardiac and peripheral angiographic procedures. Here we describe the case of a 75-year-old female...
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Percutaneous Ultrasound-Guided Thrombin Injection in Iatrogenic Arterial Pseudoaneurysms: Effectiveness and Complications

Koh YH, Kim HS, Kim HS, Min SK

  • KMID: 1841257
  • J Korean Soc Ultrasound Med.
  • 2005 Sep;24(3):145-150.
PURPOSE: To evaluate and describe the efficacy and side effects of a percutaneous thrombin injection under ultrasonography guidance for the treatment of iatrogenic pseudoaneurysms. MATERIALS AND METHODS: Eighteen consecutive iatrogenic...
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Antibacterial Effect of Lidocaine, Thrombin, and Epinephrine

Kim JW, Lee DG, Chun HS, Kim SJ, Kim SC, Ahn JH, Kim CH, Kwan SS, Kim YK, Kim KH, Moon HS, Shin WS, Song JS, Park SH

  • KMID: 2135271
  • Infect Chemother.
  • 2005 Dec;37(6):345-349.
BACKGROUND: We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. MATERIALS AND...
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LB30057, a Direct Thrombin Inhibitor, the Effect of Restenosis in Porcine Coronary Injury Model

Yoo BS, Yoon J, Yoon KH, Lee SK, Lee SH, Kim JY, Ko JY, Hwang SO, Choe KH

BACKGROUND AND OBJECTIVES: In a previous study, LB30057 was found to inhibit smooth muscle cell proliferation in a dose dependent manner, and prolonged 1 4-day oral administration of LB30057 is...
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Effect on hyaluronic acid as substitute of thrombin mixture in application of platelet rich plasma

Min SK, Oh SH, Kim JH, Cha SR, Kim YS, Kim EC

  • KMID: 1640468
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2004 Jul;26(4):325-333.
Recently, Platelet rich plasma(PRP) is commonly used in aspect of containing autogenous source of several growth factors that could preventing from infection and enhancing bone formation capacity and easily handling...
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The Significance of Thrombin Activable Fibrinolysis Inhibitor in Ischemic Stroke

Kim YC, Lee YK, Park MJ, Kang HJ, Kang SH, Cho HC, Lee BC, Yu KH

  • KMID: 2143202
  • Korean J Lab Med.
  • 2004 Dec;24(6):347-351.
BACKGROUND: Thrombin/thrombomodulin complex activates thrombin activable fibrinolysis inhibitor (TAFI) to active TAFI (TAFIa), which in turn catalyzes the hydrolysis of C-terminal lysine residues of partially degraded fibrin. The fibrin that...
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Amniotic Fluid Thrombin Activation in Intrauterine Infection and Preterm Parturition

Park KH, Cho YK

  • KMID: 2271970
  • Korean J Obstet Gynecol.
  • 2003 Feb;46(2):387-393.
OBJECTIVE: Disseminated intravascular coagulation (DIC) is a serious and life-threatening complication of amniotic fluid embolism and chorioamnionitis. DIC results from excessive thrombin activity leading to a consumptive coagulopathy. The mechanisms...
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The Effect of Long Distance Air-travel on Serum Viscosity and Prothrombin Time

Kim JH, Cho JH, Nam YY, Lee HS, Kim KC, Roh SC, Park NW, Lee WK

  • KMID: 2355666
  • Korean J Aerosp Environ Med.
  • 2002 Sep;12(3):120-125.
BACKGROUND: Economy class syndrome is medically described as deep vein thrombosis, it is worldwide issued that Long-Distance Air-Travel is a risk factor for venous thromboemborism. Some study provides evidence and...
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Iatrogenic Pseudoaneurysm of Iliac-femoral Artery; the Efficacy of Ultrasound-guided Thrombin Injection Therapy

Kang JH, Cho SH, Koh YH, Seo TS, Park YH, Lee WK, Min SK

  • KMID: 2209469
  • J Korean Surg Soc.
  • 2002 Jun;62(6):503-507.
PURPOSE: As a consequence of the widespread application of coronary and peripheral interventional procedures, the incidence of a femoral pseudoaneurysm is increasing. Along with the traditional surgical approach, ultrasound-guided compression...
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A Correlation of Prothrombin Time in Citrated Specimens and EDTA Specimens Examined by Owren Method

Ahn JJ, Park JW

  • KMID: 1889924
  • Korean J Lab Med.
  • 2002 Jun;22(3):163-168.
BACKGROUND: Sodium citrate has been used as a coagulation test because factor V and VIII are more stable in a citrated specimen. Ethylenediaminetetraacetic acid (EDTA) has been used for the...
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LB30057, A Direct Thrombin Inhibitor, Inhibits Vascular Smooth Muscle Cell proliferation in vitro and the Neointimal Hyperplasia in Rat Carotid Injury Model

Yoo BS, Yoon J, Lee SK, Yoon KH, Lee SH, Ko JY, Choi HM, Park HC, Hwang SO, Choe KH

BACKGROUND: Recent data showed prolonged administration of direct thrombin inhibitor might be needed to counteract the persistent thrombin activity and reduce the neointimal hyperplasia after arterial injury. We hypothesized that...
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