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Association of vitamin D deficiency with clinical outcomes in critically ill Korean children

Jhang WK, Kim DH, Park SJ

BACKGROUND/OBJECTIVES: Vitamin D is a pleiotropic hormone that affects various body organ systems. We evaluated the prevalence of a vitamin D deficiency (VDD) and its potential role in the clinical...
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Percutaneous Thrombin Injection for the Treatment of Post-Procedural Iatrogenic Pseudoaneurysms

Park S, Shin JH, Ko GY, Gwon DI, Ko HK, Kim JW

PURPOSE: To report our clinical experience of thrombin injection for iatrogenic pseudoaneurysms of peripheral arteries with or without balloon dilatation and coil embolization as adjunctive techniques. MATERIALS AND METHODS: A total...
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Wound healing effect of regenerated oxidized cellulose versus fibrin sealant patch: An in vivo study

Yoon HS, Na YC, Choi KH, Huh WH, Kim JM

BACKGROUND: Topical hemostatic agents are used when ligation, electrocauterization, or other conventional hemostatic methods are impractical. Because a hemostatic agent is a foreign body, it can cause foreign body reactions,...
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Characterization of the distinct mechanism of agonist-induced canine platelet activation

Chaudhary , Kim S

Platelet activation has a major role in hemostasis and thrombosis. Various agonists including adenosine diphosphate (ADP) and thrombin interact with G protein-coupled receptors (GPCRs) which transduce signals through various G...
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Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment

Joo HJ, Park JY, Hong SJ, Kim KA, Lee SH, Cho JY, Park JH, Yu CW, Lim DS

BACKGROUND/AIMS: Although epigallocatechin-3-gallate (EGCG), which is found in high contents in the dried leaves of green tea, has been reported to have an anti-platelet effect, synergistic effects of EGCG in...
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Comparative Analysis of Platelet-rich Plasma Effect on Tenocytes from Normal Human Rotator Cuff Tendon and Human Rotator Cuff Tendon with Degenerative Tears

Yoon JY, Lee SY, Shin S, Yoon KS, Jo CH

BACKGROUND: Platelet-rich plasma (PRP) stimulates cell proliferation and enhances matrix gene expression and synthesis. However, there have been no comparative study of the PRP effect on the normal and degenerative...
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Global hemostatic assay of different target procoagulant activities of factor VIII and factor IX

Yoo KY, Jung SY, Hwang SH, Lee SM, Park JH, Nam HJ

BACKGROUND: Korean National Health Insurance reimburses factor VIII (FVIII) and factor IX (FIX) clotting factor concentrate (CFC) infusions to discrepant activity levels, allowing elevation of FVIII activity to 60 IU/dL...
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A Case of Intraoperative Anaphylaxis Caused by Bovine-Derived Thrombin

Park HJ, Suk KS, Park JW

Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and...
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Life-threatening Hemorrhage Caused by Mandibular Arteriovenous Malformation: A Case Report

Kim DW, Sol IS, Kim MJ, Kim SY, Kim JD, Choi BS, Kim YH, Kim DJ, Kim BM, Jung SY, Nam W, Kim KW, Sohn MH, Kim KE

Arteriovenous malformation (AVM) of the mandible is a rare vascular condition that can manifest as a wide range of symptoms and, on rare occasions, cause fatal hemorrhage. The symptoms of...
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Endovascular treatment of pancreatitis-related gastrointestinal bleeding

Noh SY, Shin JH

Hemorrhage following pancreatitis may become complicated during the disease course and with possibly fatal consequences. Radiologic findings are as follows: the presence of hematomas, hemorrhagic pseudocysts, extravasation of contrast media...
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Postoperative Spinal Epidural Hematoma: The Danger Caused by the Misuse of Thrombin-Containing Local Hemostatics

Ahn DK, Shin WS, Kim GW, Koo KH

STUDY DESIGN: Retrospective case-control study. PURPOSE: To examine the hypothesis that the misuse of thrombin-containing local hemostatics (TCLH) increases the risk of postoperative spinal epidural hematoma (POSEH). OVERVIEW OF LITERATURE: Many studies...
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Benefits of Thromboelastography and Thrombin Generation Assay for Bleeding Prediction in Patients With Thrombocytopenia or Hematologic Malignancies

Kim SY, Gu JY, Yoo HJ, Kim JE, Jang S, Choe S, Koh Y, Kim I, Kim HK

BACKGROUND: Thromboelastography (TEG) provides comprehensive information on the whole blood clot formation phases, whereas thrombin generation assay (TGA) reveals the endogenous thrombin levels in plasma. We investigated the potential significance...
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Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System

Leem E, Jeong KH, Won SY, Shin WH, Kim SR

Although accumulating evidence suggests that microglia-mediated neuroinflammation may be crucial for the initiation and progression of Parkinson's disease (PD), and that the control of neuroinflammation may be a useful strategy...
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Focused Update of Guidelines for Antithrombotic Management of Patients with Atrial Fibrillation and Ischemic Stroke or Transient Ischemic Attack

Jung KH, Yu KH, Kim YD, Park JM, Hong KS, Rha JH, Kwon SU, Bae HJ, Heo JH, Lee BC, Yoon BW

Cardioembolic stroke related to atrial fibrillation is problematic due to high recurrence, mortality, and morbidity rates. The optimal anticoagulant therapy therefore needs to be applied to prevent the occurrence of...
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Dabigatran approaching the realm of heparin-induced thrombocytopenia

Ho PJ, Siordia JA

Heparin-induced thrombocytopenia (HIT) is a serious, immune mediated complication of exposure to unfractionated or low-molecular-weight heparin. Though rare, it is a condition associated with high morbidity and mortality that requires...
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Spontaneous Pseudoaneurysm of the Uterine Artery during Pregnancy Treated by Direct Thrombin Injection: A Case Report

Hong JH, Kim SH, Kim YH

Pseudoaneurysm of uterine artery during pregnancy is a very rare disease. It is mostly associated with uterine artery injury, usually occurring after proceeding conditions such as history of gynecologic operation...
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Why Cannot Suction Drains Prevent Postoperative Spinal Epidural Hematoma?

Ahn DK, Shin WS, Kim JW, Yi SM

BACKGROUND: Postoperative spinal epidural hematoma (POSEH) is different from spontaneous or post-spinal procedure hematoma because of the application of suction drains. However, it appeared that suction drains were not effective...
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Guidance for Endoscopic Procedures in Patients Taking Novel Oral Anticoagulants

Kim KO

Anticoagulant agents are used to reduce the risk of thromboembolic complications in patients with atrial fibrillation or deep vein thrombosis. Several new generation of oral anticoagulants have been approved. These...
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New Oral Anticoagulants: General Features and Review of Pivotal Clinical Trials

Jang SW

For the last half century, vitamin K antagonists (VKAs) have been used for treatment and prevention of venous thromboembolism and stroke prevention in patients with atrial fibrillation. However, their fragile...
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Role of Coagulation Factor 2 Receptor during Respiratory Pneumococcal Infections

Shin SG, Bong Y, Lim JH

Coagulation factor 2 receptor (F2R), also well-known as a protease-activated receptor 1 (PAR1), is the first known thrombin receptor and plays a critical role in transmitting thrombin-mediated activation of intracellular...
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