- Molecular Mechanism of Reactive Oxygen Species-dependent ASK1 Activation in Innate Immunity
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Yamauchi S, Noguchi T, Ichijo H
- KMID: 2054252
- Immune Netw.
- 2008 Mar;8(1):1-6.
- doi: 10.4110/in.2008.8.1.1
Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses... -
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- Overexpressed Mitochondrial Thioredoxin Protects PC12 Cells from Hydrogen Peroxide and Serum-deprivation
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Lee YS, Yu SA
- KMID: 1607352
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):33-37.
Oxidative damage to mitochondria is a critical mechanism in necrotic or apoptotic cell death induced by many kinds of toxic chemicals. Thioredoxin (Trx) family proteins are known to play protective... -
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- Downregulation of Reactive Oxygen Species in Apoptosis
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Jeong CH, Joo SH
- KMID: 2161518
- J Cancer Prev.
- 2016 Mar;21(1):13-20.
- doi: 10.15430/JCP.2016.21.1.13
Generation of reactive oxygen species (ROS) by diverse anti-cancer drugs or phytochemicals has been closely related with the induction of apoptosis in cancers. Also, the downregulation of ROS by these... -
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- Secreted Proteins of Helicobacter pylori Identified using Pulse-Chase Analysis
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Kim NY
- KMID: 2240155
- Korean J Gastroenterol.
- 2002 Aug;40(2):94-104.
BACKGROUND/AIMS: Helicobacter pylori (H. pylori) may cause gastric epithelial damage due to secretion of pathogenic proteins. This study was performed to identify proteins secreted by H. pylori and to investigate... -
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- Diagnosis and Management of Grain-Induced Asthma
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Quirce S, Diaz-Perales A
- KMID: 2260277
- Allergy Asthma Immunol Res.
- 2013 Nov;5(6):348-356.
- doi: 10.4168/aair.2013.5.6.348
Grain-induced asthma is a frequent occupational allergic disease mainly caused by inhalation of cereal flour or powder. The main professions affected are bakers, confectioners, pastry factory workers, millers, farmers, and... -
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- Protective Effect of Thiore doxin on Bovine Corneal Endothelial Cells Damaged by Oxidative Stresses
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Lee DY, Lee YS
- KMID: 2127733
- J Korean Ophthalmol Soc.
- 2000 Oct;41(10):2060-2068.
Reactive oxygen species including hydrogen peroxide are known to induce morphological and functional derangement of corneal endothelium, thus causing loss of corneal deturgescence. Among the antioxidants, thioredoxin has been recently... -
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- Peroxiredoxin-3 Is Involved in Bactericidal Activity through the Regulation of Mitochondrial Reactive Oxygen Species
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Lee S, Wi SM, Min Y, Lee KY
- KMID: 2362802
- Immune Netw.
- 2016 Dec;16(6):373-380.
- doi: 10.4110/in.2016.16.6.373
Peroxiredoxin-3 (Prdx3) is a mitochondrial protein of the thioredoxin family of antioxidant peroxidases and is the principal peroxidase responsible for metabolizing mitochondrial hydrogen peroxide. Recent reports have shown that mitochondrial... -
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- Serum Thioredoxin 1 Level Has Close Relation with Myocardial Damage Amount in Acute Myocardial Infarction Patients
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Shim YK, Kim JT, Seong MH, Kim YJ, Shim TJ, Kim SM, Lee SY, Bae JW, Kim KS, Hwang KK, Kim DW, Cho MC
- KMID: 1778821
- J Korean Med Sci.
- 2012 Oct;27(10):1162-1169.
- doi: 10.3346/jkms.2012.27.10.1162
Thioredoxin-1 (Trx-1) is one of important anti-oxidative molecules to overcome the oxidative stress. The aim of the present study is to investigate the clinical relationship between serum concentration of Trx-1... -
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- Expression Pattern of the Thioredoxin System in Human Endothelial Progenitor Cells and Endothelial Cells Under Hypoxic Injury
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Park KJ, Kim YJ, Choi EJ, Park NK, Kim GH, Kim SM, Lee SY, Bae JW, Hwang KK, Kim DW, Cho MC
- KMID: 2225164
- Korean Circ J.
- 2010 Dec;40(12):651-658.
- doi: 10.4070/kcj.2010.40.12.651
BACKGROUND AND OBJECTIVES: The thioredoxin (TRx) system is a ubiquitous thiol oxidoreductase pathway that regulates cellular reduction/oxidation status. Although endothelial cell (EC) hypoxic damage is one of the important pathophysiologic... -
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- Investigation of Oxidative Stress and Development of Lower Urinary Tract Symptoms in the Urinary Bladder following Partial Bladder Outlet Obstruction by Proteomic Approach
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Shim JH, Kim HJ
- KMID: 2293813
- Korean J Urol.
- 2005 Dec;46(12):1337-1343.
PURPOSE: This study investigated the pathophysiological mechanism using the proteomic approach to detect the marker proteins for the development of lower urinary tract symptoms following a partial bladder outlet obstruction... -
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- Application of Hantavirus N Protein Expressed by E. coli System
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Yu CH, Nam JH, Choi TK, Ju YR, Lee CH, Shin YH, Park KY
- KMID: 2055007
- J Bacteriol Virol.
- 2004 Jun;34(2):147-155.
Hantaan viruses cause haemorrhagic fever with renal syndrome (HFRS), resulting in severe morbidity and mortality in humans. The genome of Hantaan virus is composed of three segmented and single stranded... -
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- Cytotoxicity of Diamide and the Protective Effect of Thioredoxin on Diamide-Induced Vasculotoxicity in Vascular Endothelial Cells
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Ra EY, Seok JE, Lee EH, Lee CW, Yoon HS, Park ST
- KMID: 1938937
- Korean Circ J.
- 2001 Nov;31(11):1185-1193.
- doi: 10.4070/kcj.2001.31.11.1185
BACKGROUND AND OBJECTIVES: This study was designed to examine the effects of diamide and thioredoxin (TRX) on vascular endothelial cells in order to clarify the mechanism by which vascular damage... -
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- Exogenous rhTRX reduces lipid accumulation under LPS-induced inflammation
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Han GY, Lee EK, Park HW, Kim HJ, Kim CW
- KMID: 2155336
- Exp Mol Med.
- 2014 Jan;46(1):e71.
- doi: 10.1038/emm.2013.136
Redox-regulating molecule, recombinant human thioredoxin (rhTRX) which shows anti-inflammatory, and anti-oxidative effects against lipopolysaccharide (LPS)-stimulated inflammation and regulate protein expression levels. LPS-induced reactive oxygen intermediates (ROI) and NO production were... -
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- Differential Expression of Peroxiredoxin Isotypes in Cultured Cells from Human and Rat Skin
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Ahn EY, Lee JB, Won YH, Lee SC
- KMID: 2230317
- Korean J Dermatol.
- 2000 Nov;38(11):1481-1487.
BACKGROUND: Peroxiredoxin(Prx) is a novel peroxidase family to remove hydrogen peroxide using thioredoxin system, which is consisted of thioredoxin, thioredoxin reductase and NADPH. Several enzymatic antioxidants, such as superoxide dismutase,... -
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- Genome Mapping of an Extreme Thermophile, Thermus caldophilus GK24
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Park JH, Park BC, Koch SH, Kim JS, Koh JH, Yang MH, Kim YS, Kim CH, Kim MH, Kwon ST, Lee DS
- KMID: 1973995
- Genomics Inform.
- 2003 Sep;1(1):50-54.
Genome of an extreme thermophile, Thermus caldophilus GK24 has been analyzed to construct the genomic map. The genomic DNAs encapsulated in agarose gel were digested with SspI, EcoRI, SpeI, and... -
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- Expression of Peroxiredoxin I in the Epidermis of Vitiligo
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Quan G, Piao MS, Choi JY, Chun JS, Lee JB, Lee SC
- KMID: 2248128
- Korean J Dermatol.
- 2008 Jun;46(6):736-741.
BACKGROUND: Although the pathogenesis of vitiligo isn't fully understood, a recent study demonstrates that oxidative stress plays an important role to induce vitiligo. Peroxiredoxin (Prx) is a novel peroxidase family... -
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- Studies on In Vivo Function of Peroxiredoxins in Knockout Mice
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Yu DY
- KMID: 2168237
- Hanyang Med Rev.
- 2013 May;33(2):97-103.
- doi: 10.7599/hmr.2013.33.2.97
Peroxiredoxins (Prxs) are a family of antioxidant proteins that reduce peroxide levels by using reducing agents such as thioredoxin. These proteins were characterized to have a number of cellular functions,... -
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- Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats
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Kang JB, Park DJ, Koh PO
- KMID: 2470014
- Lab Anim Res.
- 2019 Dec;35(4):172-179.
- doi: 10.1186/s42826-019-0026-9
Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal cerebral... -
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- Effects of Thioredoxin on Oxidative Neuronal Cell Injury
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Kim H, Kim GH, Lee YS
- KMID: 2335405
- J Korean Pediatr Soc.
- 1999 May;42(5):686-696.
PURPOSE: Thioredoxin is an endogenous antioxidant which directly scavenges reactive oxygen species(ROS) and regenerates oxidatively damaged protein by reducing potential at the redox active disulfide(-Cys-Gly-Pro-Cys-) site. Under oxidative stress, thiredoxin... -
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- Effects of Thioredoxin on Apoptosis-Inducing Neuronal Cell Injury
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Kim H, Kim GH, Lee YS
- KMID: 2041987
- J Korean Pediatr Soc.
- 1999 Jun;42(6):825-832.
PURPOSE: Thioredoxin is an endogenous antioxidant. It regulates the activities of transcriptional factors such as NF-kB(nuclear factor kappa B)and AP-1(activator protein-1) and it increases the synthesis of cytokines, preventing cellular... -
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