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The effect of alpha-lipoic acid on expression of VCAM-1 in type 2 diabetic rat

Ismawati , Mukhyarjon , Asni E, Romus I

Macrovascular diabetes complications are generally caused by a process called atherosclerosis. Evidences suggest that to initiate atherosclerosis, oxidated low-density lipoprotein (oxLDL) has to promote the expression of adhesion molecule. Several...
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Anti-Inflammatory and Antioxidative Effects of Alpha Lipoic Acid on Cultured Human Sebocytes

Lee WJ, Eun DH, Kim SM, Kim JY, Jang YH, Lee SJ

No abstract available.
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Effects of High-Dose α-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea

Lee SJ, Jeong SJ, Lee YC, Lee YH, Lee JE, Kim CH, Min KW, Cha BY

BACKGROUND: Diabetic cardiac autonomic neuropathy (CAN) is one of the important complications of diabetes. It is characterized by reduced heart rate variability (HRV). METHODS: In this randomized, double-blind, placebo-controlled, multicenter trial,...
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Insulin autoimmune syndrome associated with alpha-lipoic acid in a young woman with no concomitant disease

Lee SB, Lee MY, You JH, Kim SH, Nam JS

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia, extremely high serum insulin levels, and high titers of autoantibodies against endogenous insulin, in the absence of exogenous insulin injection. IAS...
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Injections for nutrition and cosmetic purposes: promoted effect vs. objective evidence

Shin HY

The introduction of intravenous nutritional therapy for cosmetic and health purposes in Korea has been controversial. Because it brings ethical problems of off-label prescribing on the basis of low level...
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Comparison of R(+)-α-lipoic acid exposure after R(+)-α-lipoic acid 200 mg and 300 mg and thioctic acid 600 mg in healthy Korean male subjects

Yoon J, Moon SJ, Lee KO, Yoon SH, Jang IJ, Yu KS, Lee S

Alpha-lipoic acid, a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. R(+)-α-lipoic acid shows superior antioxidative effects to its racemate. We compared the pharmacokinetics...
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alpha-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-kappaB in H. pylori-Infected Gastric Epithelial AGS Cells

Choi JH, Cho SO, Kim H

The epithelial cytokine response, associated with reactive oxygen species (ROS), is important in Helicobacter pylori (H. pylori)-induced inflammation. H. pylori induces the production of ROS, which may be involved in...
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Management of Diabetic Peripheral Neuropathy

Kang MS, Kim CH

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus. The prevalence of neuropathic pain is estimated to occur in about 30-50% of all diabetic patients. Clinical symptoms vary...
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Lipoic Acid Prevents the Changes of Intracellular Lipid Partitioning by Free Fatty Acid

Kim DC, Jun DW, Jang EC, Kim SH, Kim EK, Lee SP, Lee KN, Lee HL, Lee OY, Yoon BC, Choi HS

  • KMID: 2135074
  • Gut Liver.
  • 2013 Mar;7(2):221-227.
BACKGROUND/AIMS: It is suggested that the hepatic lipid composition is more important than lipid quantity in the pathogenesis of non-alcoholic steatohepatitis. We examined whether lipoic acid (LA) could alter intrahepatic...
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Recurrent Insulin Autoimmune Syndrome Caused by alpha-Lipoic Acid in Type 2 Diabetes

Bae SM, Bae MN, Kim EY, Kim IK, Seo MW, Shin JK, Cho SR, Jeong GH

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies in the absence of exogenous insulin administration. Some drugs containing sulfhydryl compounds are known to initiate the...
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alpha-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat diet

Seo EY, Ha AW, Kim WK

  • KMID: 2313593
  • Nutr Res Pract.
  • 2012 Jun;6(3):195-200.
The purpose of this study was to investigate the effects of alpha-lipoic acid on body weight and lipid profiles in Sprague-Dawley rats fed a high fat diet (HFD). After 4...
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Alpha-Lipoic Acid Decreases Iodine Uptake in the Rat Thyroid Cell Line FRTL-5

Yim JH, Kim TY, Ruiz-Llorente S, Kim WG, Han JM, Jeon MJ, Kim WB, Shong YK

BACKGROUND AND OBJECTIVES: Alpha-lipoic acid (ALA) is a naturally occurring fatty acid with strong antioxidant properties that exerts protective effects against harmful free radical damage. The aim of the present...
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Induction of ER Stress-Mediated Apoptosis by alpha-Lipoic Acid in A549 Cell Lines

Kim JI, Cho SR, Lee CM, Park ES, Kim KN, Kim HC, Lee HY

  • KMID: 2063120
  • Korean J Thorac Cardiovasc Surg.
  • 2012 Feb;45(1):1-10.
BACKGROUND: alpha-Lipoic acid (alpha-LA) has been studied as an anticancer agent as well as a therapeutic agent for diabetes and obesity. We performed this study to evaluate the anticancer effects...
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Effect of a Dual Drug-Coated Stent With Abciximab and Alpha-Lipoic Acid in a Porcine Coronary Restenosis Model

Lim KS, Hong YJ, Hachinohe , Ahmed K, Jeong MH, Kim JH, Sim DS, Lee MG, Park KH, Kim JH, Ahn Y, Cho JG, Park JC, Song SJ, Jung KW, Cho DL, Kang JC

BACKGROUND AND OBJECTIVES: The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of a stent coated with abciximab and alpha-lipoic acid (ALA) in a porcine coronary...
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Effects of alpha-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats

Kim MY, Kim EJ, Kim YN, Choi C, Lee BH

  • KMID: 2313547
  • Nutr Res Pract.
  • 2011 Oct;5(5):421-428.
alpha-Lipoic acid and L-carnosine are powerful antioxidants and are often used as a health supplement and as an ergogenic aid. The objective of this study was to investigate the effects...
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Response: Effects of alpha-lipoic Acid on Differentiation of Thyroid Cancer Cells

Kim WG, Kim WB

No abstract available.
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Letter: Effects of alpha-lipoic Acid on Differentiation of Thyroid Cancer Cells

Jung KH

No abstract available.
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Effects of alpha-lipoic Acid on Differentiation of Thyroid Cancer Cells

Kim WG, Han DH, Choi HJ, Kim EY, Kim TY, Shong YK, Kim WB

BACKGROUND: Induction of re-differentiation is necessary for the proper treatment of patients with recurrent or metastatic differentiated thyroid cancer (DTC) because cancer cells show de-differentiation in about 30% of these...
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Effects of Antioxidants in Cisplatin-Induced Renal Tubular Apoptosis

Bae EH, Lee J, Ma SK, Kim SW

The present study was designed to evaluate the possible renoprotective effects of alpha-lipoic acid (alpha-LA) in cisplatin-induced nephropathy and its role in inflammation and apoptosis in the kidney. Male Sprague-Dawley...
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Lipoic acid suppresses compound 48/80-induced anaphylaxis-like reaction

Choi YH, Chai OH, Han EH, Choi SY, Kim HT, Song CH

Alpha-lipoic acid (LA), a naturally occurring dithiol compound, is an essential cofactor in metabolic reactions involved in energy utilization. LA improves glycemic control, reduces diabetic polyneuropathies, atherosclerosis, and allergic inflammation....
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