- Dual regulatory effects of PI(4,5)P2 on TREK-2 K+ channel through antagonizing interaction between the alkaline residues (K330. and R355-357 ) in the cytosolic C-terminal helix
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Kim SE, Kim MH, Woo J, Kim SJ
- KMID: 2507740
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):555-561.
- doi: 10.4196/kjpp.2020.24.6.555
TWIK-related two-pore domain K+ channel-2 (TREK-2) has voltageindependent activity and shows additional activation by acidic intracellular pH (pH i ) via neutralizing the E332 in the cytoplasmic C terminal (Ct).... -
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- The agonistic action of URO-K10 on Kv7.4 and 7.5 channels is attenuated by co-expression of KCNE4 ancillary subunit
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Lee JE, Park CH, Kang H, Ko J, Cho S, Woo J, Chae MR, Lee SW, Kim SJ, Kim J, So I
- KMID: 2507733
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):503-516.
- doi: 10.4196/kjpp.2020.24.6.503
KCNQ family constitutes slowly-activating potassium channels among voltage-gated potassium channel superfamily. Recent studies suggested that KCNQ4 and 5 channels are abundantly expressed in smooth muscle cells, especially in lower urinary... -
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- Open channel block of Kv1.4 potassium channels by aripiprazole
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Park J, Cho KH, Lee HJ, Choi JS, Rhie DJ
- KMID: 2507736
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):545-553.
- doi: 10.4196/kjpp.2020.24.6.545
Aripiprazole is a quinolinone derivative approved as an atypical antipsychotic drug for the treatment of schizophrenia and bipolar disorder. It acts as with partial agonist activities at the dopamine D2... -
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- Layer-specific serotonergic induction of long-term depression in the prefrontal cortex of rats
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Shin D, Cho KH, Joo K, Rhie DJ
- KMID: 2507734
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):517-527.
- doi: 10.4196/kjpp.2020.24.6.517
Layer 2/3 pyramidal neurons (L2/3 PyNs) of the cortex extend their basal dendrites near the soma and as apical dendritic tufts in layer 1, which mainly receive feedforward and feedback... -
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- Nanoscale imaging of rat atrial myocytes by scanning ion conductance microscopy reveals heterogeneity of T-tubule openings and ultrastructure of the cell membrane
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Park SH, Kim A, An J, Cho HS, Kang TM
- KMID: 2507735
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):529-543.
- doi: 10.4196/kjpp.2020.24.6.529
In contrast to ventricular myocytes, the structural and functional importance of atrial transverse tubules (T-tubules) is not fully understood. Therefore, we investigated the ultrastructure of T-tubules of living rat atrial... -
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- 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-Glucoside modulated human umbilical vein endothelial cells injury under oxidative stress
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Guo Y, Fan W, Cao S, Xie Y, Hong J, Zhou H, Wan H, Jin B
- KMID: 2507730
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):473-479.
- doi: 10.4196/kjpp.2020.24.6.473
Endothelial cell injury is a major contributor to cardiovascular diseases. The 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-Glucoside (TSG) contributes to alleviate human umbilical vein endothelial cells (HUVECs) injury through mechanisms still know a little. This study... -
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- Trends in the development of human stem cell-based non-animal drug testing models
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Lee SJ, Lee HA
- KMID: 2507727
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):441-452.
- doi: 10.4196/kjpp.2020.24.6.441
In vivo animal models are limited in their ability to mimic the extremely complex systems of the human body, and there is increasing disquiet about the ethics of animal research.... -
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- Anti-arthritic activity of D-carvone against complete Freund’s adjuvant-induced arthritis in rats through modulation of inflammatory cytokines
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Chen G, Song Y, Ma F, Ma Y
- KMID: 2507728
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):453-462.
- doi: 10.4196/kjpp.2020.24.6.453
Chronic joint pain due to loss of cartilage function, degradation of subchondral bone, and related conditions are common plights of an arthritis patient. Antioxidant compounds could solve the problems in arthritic... -
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- Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells
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Lee YJ, Park KS, Nam HS, Cho MK, Lee SH
- KMID: 2507732
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):493-502.
- doi: 10.4196/kjpp.2020.24.6.493
Apigenin, a naturally occurring flavonoid, is known to exhibit significant anticancer activity. This study was designed to determine the effects of apigenin on two malignant mesothelioma cell lines, MSTO-211H and... -
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- AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis
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Xu L, Wu J, Li N, Jiang C, Guo Y, Cao P, Wang D
- KMID: 2507731
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):481-492.
- doi: 10.4196/kjpp.2020.24.6.481
The present study aimed to examine the effect of allyl isothiocyanate (AITC) on chronic obstructive pulmonary disease and to investigate whether upregulation of multidrug resistance-associated protein 1 (MRP1) associated with... -
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- Direct reprogramming of fibroblasts into diverse lineage cells by DNA demethylation followed by differentiating cultures
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Yang DW, Moon J, Ko HM, Shin YK, Fukumoto S, Kim SH, Kim MS
- KMID: 2507729
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):463-472.
- doi: 10.4196/kjpp.2020.24.6.463
Direct reprogramming, also known as a trans-differentiation, is a technique to allow mature cells to be converted into other types of cells without inducing a pluripotent stage. It has been... -
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