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Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse

Hong SH, Sung R, Kim YC, Suzuki H, Choi W, Park YJ, Ji IW, Kim CH, Myung SC, Lee MY, Kang TM, You RY, Lee KJ, Lim SW, Yun HY, Song YJ, Xu WX, Kim HS, Lee SJ

Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K+ channels. Because contractility of uterine...
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Expression and Activity of the Na-K ATPase in Ischemic Injury of Primary Cultured Astrocytes

Kim MJ, Hur J, Ham IH, Yang HJ, Kim Y, Park S, Cho YW

Astrocytes are reported to have critical functions in ischemic brain injury including protective effects against ischemia-induced neuronal dysfunction. Na-K ATPase maintains ionic gradients in astrocytes and is suggested as an...
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Decreasing Effect of Lidocaine.HCl on the Thickness of the Neuronal and Model Membrane

Park SM, Park JS, Kim JH, Baek JH, Yoon TG, Lee DK, Ryu WH, Chung IK, Sohn UD, Jang HO, Yun I

This study examined the mechanism of action of a local anesthetic, lidocaine.HCl. Energy transfer between the surface fluorescent probe, 1-anilinonaphthalene-8-sulfonic acid, and the hydrophobic fluorescent probe, 1,3-di(1-pyrenyl) propane, was used...
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A Review on Renal Toxicity Profile of Common Abusive Drugs

Singh VP, Singh N, Jaggi AS

Drug abuse has become a major social problem of the modern world and majority of these abusive drugs or their metabolites are excreted through the kidneys and, thus, the renal...
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Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats

Lan Y, Yang YZ, Jiang X, Li LW, Jin GS, Kim MS, Park BR, Jin YZ

Contribution of the vestibular end organ to regulation of arterial pressure was quantitatively compared with the role of baroreceptors in terms of baroreflex sensitivity and c-Fos protein expression in the...
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Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells

Bae YH, Ryu JH, Park HJ, Kim KR, Wee HJ, Lee OH, Jang HO, Bae MK, Kim KW, Bae SK

Notch1 has been reported to be highly expressed in triple-negative and other subtypes of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present...
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Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by Desipramine and Citalopram

Choi SH, Chung S, Cho JH, Cho YH, Kim JW, Kim JM, Kim HJ, Kim HJ, Shin KH

Rodents exposed to a 15-min pretest swim in the forced swimming test (FST) exhibit prolonged immobility in a subsequent 5-min test swim, and antidepressant treatment before the test swim reduces...
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Korean Red Ginseng Induced Cardioprotection against Myocardial Ischemia in Guinea Pig

Lim KH, Kang CW, Choi JY, Kim JH

This study was designed to evaluate the protective effect of Korean red ginseng (KRG) against ischemia/reperfusion (I/R) injury in isolated guinea pig heart. KRG has been shown to possess various...
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Neuronal Responses in the Globus Pallidus during Subthalamic Nucleus Electrical Stimulation in Normal and Parkinson's Disease Model Rats

Ryu SB, Bae EK, Kim J, Hwang YS, Im C, Chang JW, Shin HC, Kim KH

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been widely used as a treatment for the movement disturbances caused by Parkinson's disease (PD). Despite successful application of DBS,...
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Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells

Youn CK, Park SJ, Li MH, Lee MY, Lee KY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ

Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine...
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Effect of Lutein on L-NAME-Induced Hypertensive Rats

Sung JH, Jo YS, Kim SJ, Ryu JS, Kim MC, Ko HJ, Sim SS

We investigated the antihypertensive effect of lutein on NG-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure...
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High Glucose Induces Connective Tissue Growth Factor Expression and Extracellular Matrix Accumulation in Rat Aorta Vascular Smooth Muscle Cells Via Extracellular Signal-Regulated Kinase 1/2

Ha YM, Lee DH, Kim M, Kang YJ

Connective tissue growth factor (CTGF) is a potent pro-fibrotic factor, which is implicated in fibrosis through extracellular matrix (ECM) induction in diabetic cardiovascular complications. It is an important downstream mediator...
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(-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion

Al-Ajmi N, Al-Maghrebi M, Renno WM

The anti-apoptotic effect of (-)-epigallocatechin-3-gallate (EGCG) during unilateral testicular torsion and detorsion (TT/D) was established in our previous study. In mice, the smallest inhibitor of apoptosis, survivin, is alternatively spliced...
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Neuroprotective Effects of AMP-Activated Protein Kinase on Scopolamine Induced Memory Impairment

Kim SJ, Lee JH, Chung HS, Song JH, Ha J, Bae H

AMP-activated protein kinase (AMPK), an important regulator of energy metabolism, is activated in response to cellular stress when intracellular levels of AMP increase. We investigated the neuroprotective effects of AMPK...
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Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs

Cho YJ, Yi CO, Jeon BT, Jeong YY, Kang GM, Lee JE, Roh GS, Lee JD

A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties,...
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