- Comparison of Parametric and Bootstrap Method in Bioequivalence Test
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Ahn BJ, Yim DS
- KMID: 1982570
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):367-371.
- doi: 10.4196/kjpp.2009.13.5.367
The estimation of 90% parametric confidence intervals (CIs) of mean AUC and Cmax ratios in bioequivalence (BE) tests are based upon the assumption that formulation effects in log-transformed data are... -
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- Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior
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Kwak C, Lee SH, Kaang BK
- KMID: 1982568
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):357-360.
- doi: 10.4196/kjpp.2009.13.5.357
It is hypothesized that a number of environmental factors affect animals' behavior. Without controlling these variables, it is very hard for researchers to get not only reliable, but replicable data... -
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- Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs
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Lee JH, Cheong HM, Kang MY, Kim SY, Kang Y
- KMID: 1982566
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):343-348.
- doi: 10.4196/kjpp.2009.13.5.343
53BP1 is an important genome stability regulator, which protects cells against double-strand breaks. Following DNA damage, 53BP1 is rapidly recruited to sites of DNA breakage, along with other DNA damage... -
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- Possible Involvement of Ca2+ Activated K+ Channels, SK Channel, in the Quercetin-Induced Vasodilatation
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Nishida S, Satoh H
- KMID: 1982569
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):361-365.
- doi: 10.4196/kjpp.2009.13.5.361
Effects of quercetin, a kind of flavonoids, on the vasodilating actions were investigated. Among the mechanisms for quercetin-induced vasodilatation in rat aorta, the involvement with the Ca2+ activated K+ (KCa)... -
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- Ape1/Ref-1 Stimulates GDNF/GFR alpha1-mediated Downstream Signaling and Neuroblastoma Proliferation
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Kang MY, Kim KY, Yoon Y, Kang Y, Kim HB, Youn CK, Kim DH, Kim MH
- KMID: 1982567
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):349-356.
- doi: 10.4196/kjpp.2009.13.5.349
We previously reported that glial cell line-derived neurotropic factor (GDNF) receptor alpha1 (GFR alpha1) is a direct target of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1). In the present study, we further analyzed... -
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- Optimized Immunohistochemical Analysis of Cerebellar Purkinje Cells Using a Specific Biomarker, Calbindin D28k
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Kim BJ, Lee SY, Kim HW, Park EJ, Kim J, Kim SJ, So I, Jeon JH
- KMID: 1982571
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):373-378.
- doi: 10.4196/kjpp.2009.13.5.373
Cerebellar Purkinje cells (PCs) play a crucial role in motor functions and their progressive degeneration is closely associated with spinocerebellar ataxias. Although immunohistochemical (IHC) analysis can provide a valuable tool... -
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- Preventing Extracellular Diffusion of Trigeminal Nitric Oxide Enhances Formalin-induced Orofacial Pain
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Jung HS, Jeon HB, Jeon IS, Lee BJ, Yoo HW, Ahn DK, Youn DH
- KMID: 1982572
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):379-383.
- doi: 10.4196/kjpp.2009.13.5.379
Nitric oxide (NO), a diffusible gas, is produced in the central nervous system, including the spinal cord dorsal horn and the trigeminal nucleus, the first central areas processing nociceptive information... -
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- Downregulation of Angiotensin II-Induced 12-Lipoxygenase Expression and Cell Proliferation in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats by CCL5
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Kim JH, Kim HS
- KMID: 1982573
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):385-392.
- doi: 10.4196/kjpp.2009.13.5.385
Angiotensin II (Ang II) plays an important role in vascular hypertension. The role of the chemokine CCL5 on Ang II-induced activities in vascular smooth muscle cells (VSMCs) has not been... -
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- Increase of NADPH-diaphorase Expression in Hypothalamus of Stat4 Knockout Mice
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Hong MS, Song JY, Yun DH, Cho JJ, Chung JH
- KMID: 1982565
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):337-341.
- doi: 10.4196/kjpp.2009.13.5.337
Signal transducer and activator of transcription 4 (STAT4), a STAT family member, mediates interleukin 12 (IL12) signal transduction. IL12 is known to be related to calorie-restricted status. In the central... -
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- Arachidonic Acid Activates K+-Cl--cotransport in HepG2 Human Hepatoblastoma Cells
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Lee YS
- KMID: 1982575
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):401-408.
- doi: 10.4196/kjpp.2009.13.5.401
K+-Cl--cotransport (KCC) has been reported to have various cellular functions, including proliferation and apoptosis of human cancer cells. However, the signal transduction pathways that control the activity of KCC are... -
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- The Influences of G Proteins, Ca2+, and K+ Channels on Electrical Field Stimulation in Cat Esophageal Smooth Muscle
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Park JH, Kim HS, Park SY, Im C, Jeong JH, Kim IK, Sohn UD
- KMID: 1982574
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):393-400.
- doi: 10.4196/kjpp.2009.13.5.393
NO released by myenteric neurons controls the off contraction induced by electrical field stimulation (EFS) in distal esophageal smooth muscle, but in the presence of nitric oxide synthase (NOS) inhibitor,... -
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