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10 results

Ca2+/calmodulin-dependent regulation of polycystic kidney disease 2-like-1 by binding at C-terminal domain

Baik JY, Park EYJ, So I

  • Korean J Physiol Pharmacol.
  • 2020 May;24(3):277-286.
  • doi: 10.4196/kjpp.2020.24.3.277
Polycystic kidney disease 2-like-1 (PKD2L1), also known as polycystin- L or TRPP3, is a non-selective cation channel that regulates intracellular calcium concentration. Calmodulin (CaM) is a calcium binding protein, consisting...
Oncogenic Ras downregulates mdr1b expression through generation of reactive oxygen species

Jun S, Kim SW, Kim B, Chang IY, Park SJ

  • Korean J Physiol Pharmacol.
  • 2020 May;24(3):267-276.
  • doi: 10.4196/kjpp.2020.24.3.267
In the present study, we investigated the effect of oncogenic H-Ras on rat mdr1b expression in NIH3T3 cells. The constitutive expression of H-RasV12 was found to downregulate the mdr1b promoter...
D-Limonene mitigate myocardial injury in rats through MAPK/ ERK/NF-κB pathway inhibition

Younis NS

  • Korean J Physiol Pharmacol.
  • 2020 May;24(3):259-266.
  • doi: 10.4196/kjpp.2020.24.3.259
Cardiovascular diseases are the primary reason of mortality, among which myocardial infarction (MI) is the most dominant and prevalent. This study was considered to examine D-Limonene protective action against isoproterenol...
Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes

Seo YS, Cho IA, Kim TH, You JS, Oh JS, Lee GJ, Kim DK, Kim JS

  • Korean J Physiol Pharmacol.
  • 2020 May;24(3):249-257.
  • doi: 10.4196/kjpp.2020.24.3.249
The aim of the present study was to investigate the pathophysiological etiology of osteoarthritis that is mediated by the apoptosis of chondrocytes exposed to 25-hydroxycholesterol (25-HC), an oxysterol synthesized by...
Heat shock protein 90 inhibitor AUY922 attenuates platelet-derived growth factor-BB-induced migration and proliferation of vascular smooth muscle cells

Kim J, Lee KP, Kim BS, Lee SJ, Moon BS, Baek S

  • Korean J Physiol Pharmacol.
  • 2020 May;24(3):241-248.
  • doi: 10.4196/kjpp.2020.24.3.241
Luminespib (AUY922), a heat shock proteins 90 inhibitor, has anti-neoplastic and antitumor effects. However, it is not clear whether AUY922 affects events in vascular diseases. We investigated the effects of...
ATG5 knockout promotes paclitaxel sensitivity in drug-resistant cells via induction of necrotic cell death

Hwang SH, Yeom H, Lee M

  • Korean J Physiol Pharmacol.
  • 2020 May;24(3):233-240.
  • doi: 10.4196/kjpp.2020.24.3.233
Autophagy regulators are often effective as potential cancer therapeutic agents. Here, we investigated paclitaxel sensitivity in cells with knockout (KO) of ATG5 gene. The ATG5 KO in multidrug resistant v-Ha-ras...
Sesamin induces A549 cell mitophagy and mitochondrial apoptosis via a reactive oxygen species-mediated reduction in mitochondrial membrane potential

Yang S, Li X, Dou H, Hu Y, Che C, Xu D

  • Korean J Physiol Pharmacol.
  • 2020 May;24(3):223-232.
  • doi: 10.4196/kjpp.2020.24.3.223
Sesamin, a lipid-soluble lignin originally isolated from sesame seeds, which induces cancer cell apoptosis and autophagy. In the present study, has been reported that sesamin induces apoptosis via several pathways...
Salvianolic acid B ameliorates psoriatic changes in imiquimodinduced psoriasis on BALB/c mice by inhibiting inflammatory and keratin markers via altering phosphatidylinositol-3-kinase/ protein kinase B signaling pathway

Wang S, Zhu L, Xu Y, Qin Z, Xu A

  • Korean J Physiol Pharmacol.
  • 2020 May;24(3):213-221.
  • doi: 10.4196/kjpp.2020.24.3.213
Salvianolic acid B (SAB) is an active phytocomponent of a popular Chinese herb called Radix Salvia militiorrhiza with numerous biological properties. The anti-psoriasis activity of SAB was examined by evaluating...
Interaction of promyelocytic leukemia/p53 affects signal transducer and activator of transcription-3 activity in response to oncostatin M

Lim J, Choi JH, Park EM, Choi YH

  • Korean J Physiol Pharmacol.
  • 2020 May;24(3):203-212.
  • doi: 10.4196/kjpp.2020.24.3.203
Promyelocytic leukemia (PML) gene, through alternative splicing of its Cterminal region, generates several PML isoforms that interact with specific partners and perform distinct functions. The PML protein is a tumor...
Inhibition of chromosomal region maintenance 1 suppresses the migration and invasion of glioma cells via inactivation of the STAT3/MMP2 signaling pathway

Shan Q, Li S, Cao Q, Yue C, Niu M, Chen X, Shi L, Li H, Gao S, Liang J, Yu R, Liu X

  • Korean J Physiol Pharmacol.
  • 2020 May;24(3):193-201.
  • doi: 10.4196/kjpp.2020.24.3.193
Chromosomal region maintenance 1 (CRM1) is associated with an adverse prognosis in glioma. We previously reported that CRM1 inhibition suppressed glioma cell proliferation both in vitro and in vivo. In...

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