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Gardenia jasminoides extract and its constituent, genipin, inhibit activation of CD3/CD28 co-stimulated CD4+ T cells via ORAI1 channel

Kim HJ, Nam YR, Woo J, Kim WK, Nam JH

  • Korean J Physiol Pharmacol.
  • 2020 Jul;24(4):363-372.
  • doi: 10.4196/kjpp.2020.24.4.363
Gardenia jasminoides (GJ) is a widely used herbal medicine with antiinflammatory properties, but its effects on the ORAI1 channel, which is important in generating intracellular calcium signaling for T cell...
Analysis of temperature-dependent abnormal bursting patterns of neurons in Aplysia

Hyun NG, Hyun K, Oh S, Lee K

  • Korean J Physiol Pharmacol.
  • 2020 Jul;24(4):349-362.
  • doi: 10.4196/kjpp.2020.24.4.349
Temperature affects the firing pattern and electrical activity of neurons in animals, eliciting diverse responses depending on neuronal cell type. However, the mechanisms underlying such diverse responses are not well...
Comparative study of acute in vitro and short-term in vivo triiodothyronine treatments on the contractile activity of isolated rat thoracic aortas

López RM, López JS, Lozano J, Flores H, Carranza RA, Franco A, Castillo EF

  • Korean J Physiol Pharmacol.
  • 2020 Jul;24(4):339-348.
  • doi: 10.4196/kjpp.2020.24.4.339
We aimed to characterize the participation of rapid non-genomic and delayed non-genomic/genomic or genomic mechanisms in vasoactive effects to triiodothyronine (T3), emphasizing functional analysis of the involvement of these mechanisms...
Luteolin reduces fluid hypersecretion by inhibiting TMEM16A in interleukin-4 treated Calu-3 airway epithelial cells

Kim HJ, Woo J, Nam YR, Seo Y, Namkung W, Nam JH, Kim WK

  • Korean J Physiol Pharmacol.
  • 2020 Jul;24(4):329-338.
  • doi: 10.4196/kjpp.2020.24.4.329
Rhinorrhea in allergic rhinitis (AR) is characterized by the secretion of electrolytes in the nasal discharge. The secretion of Cl– and HCO3 – is mainly regulated by cystic fibrosis transmembrane...
Activation of the renin-angiotensin system in high fructose-induced metabolic syndrome

Kim M, Do GY, Kim I

  • Korean J Physiol Pharmacol.
  • 2020 Jul;24(4):319-328.
  • doi: 10.4196/kjpp.2020.24.4.319
High fructose intake induces hyperglycemia and hypertension. However, the mechanism by which fructose induces metabolic syndrome is largely unknown. We hypothesized that high fructose intake induces activation of the renin-angiotensin...
Exploring the beneficial role of telmisartan in sepsis-induced myocardial injury through inhibition of high-mobility group box 1 and glycogen synthase kinase-3β/nuclear factor-κB pathway

Jin Y, Wang H, Li J, Dang M, Zhang W, Lei Y, Zhao H

  • Korean J Physiol Pharmacol.
  • 2020 Jul;24(4):311-317.
  • doi: 10.4196/kjpp.2020.24.4.311
In the present experimental study, cecal ligation and puncture significantly increased the myocardial injury assessed in terms of excess release of creative kinase-MB (CK-MB), cardiac troponin I (cTnI), interleukin (IL)-6...
Combination therapy with cilostazol, aripiprazole, and donepezil protects neuronal cells from β-amyloid neurotoxicity through synergistically enhanced SIRT1 expression

Heo HJ, Park SY, Lee YS, Shin HK, Hong KW, Kim CD

  • Korean J Physiol Pharmacol.
  • 2020 Jul;24(4):299-310.
  • doi: 10.4196/kjpp.2020.24.4.299
Alzheimer’s disease (AD) is a multi-faceted neurodegenerative disease. Thus, current therapeutic strategies require multitarget-drug combinations to treat or prevent the disease. At the present time, single drugs have proven to...
Endothelial Ca2+ signaling-dependent vasodilation through transient receptor potential channels

Hong KS, Lee MG

  • Korean J Physiol Pharmacol.
  • 2020 Jul;24(4):287-298.
  • doi: 10.4196/kjpp.2020.24.4.287
Ca2+ signaling of endothelial cells plays a critical role in controlling blood flow and pressure in small arteries and arterioles. As the impairment of endothelial function is closely associated with...

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