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Gastroprokinetic agent, mosapride inhibits 5-HT₃ receptor currents in NCB-20 cells

Park YS, Sung KW

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):419-426.
  • doi: 10.4196/kjpp.2019.23.5.419
Mosapride accelerates gastric emptying by acting on 5-hydroxytryptamine type 4 (5-HTâ‚„) receptor and is frequently used in the treatment of gastrointestinal (GI) disorders requiring gastroprokinetic efficacy. We tested the effect...
Humanin suppresses receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation via AMP-activated protein kinase activation

Kang N, Kim KW, Shin DM

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):411-417.
  • doi: 10.4196/kjpp.2019.23.5.411
Humanin (HN) is a mitochondrial peptide that exhibits cytoprotective actions against various stresses and diseases. HN has been shown to induce the phosphorylation of AMP-activated protein kinase (AMPK), which is...
Differential effects of saturated and unsaturated fatty acids on vascular reactivity in isolated mesenteric and femoral arteries of rats

Vorn R, Yoo HY

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):403-409.
  • doi: 10.4196/kjpp.2019.23.5.403
Free fatty acid (FFA) intake regulates blood pressure and vascular reactivity but its direct effect on contractility of systemic arteries is not well understood. We investigated the effects of saturated...
Antitumor profiles and cardiac electrophysiological effects of aurora kinase inhibitor ZM447439

Lee HA, Kwon M, Kim HA, Kim KS

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):393-402.
  • doi: 10.4196/kjpp.2019.23.5.393
Aurora kinases inhibitors, including ZM447439 (ZM), which suppress cell division, have attracted a great deal of attention as potential novel anti-cancer drugs. Several recent studies have confirmed the anti-cancer effects...
Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner

Wijerathne TD, Kim JH, Kim MJ, Kim CY, Chae MR, Lee SW, Lee KP

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):381-392.
  • doi: 10.4196/kjpp.2019.23.5.381
Sperm function and male fertility are closely related to pH dependent K⁺ current (KSper) in human sperm, which is most likely composed of Slo3 and its auxiliary subunit leucine-rich repeat-containing...
Profiling of remote skeletal muscle gene changes resulting from stimulation of atopic dermatitis disease in NC/Nga mouse model

Lee D, Seo Y, Kim YW, Kim S, Choi J, Moon SH, Bae H, Kim HS, Kim H, Kim JH, Kim TY, Kim E, Yim S, Lim I, Bang H, Kim JH, Ko JH

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):367-379.
  • doi: 10.4196/kjpp.2019.23.5.367
Although atopic dermatitis (AD) is known to be a representative skin disorder, it also affects the systemic immune response. In a recent study, myoblasts were shown to be involved in...
Identification of phospholipase C β downstream effect on transient receptor potential canonical 1/4, transient receptor potential canonical 1/5 channels

Ko J, Myeong J, Kwak M, Jeon JH, So I

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):357-366.
  • doi: 10.4196/kjpp.2019.23.5.357
Gα(q)-coupled receptor stimulation was implied in the activation process of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heterotetrameric channels. The inactivation occurs due to phosphatidylinositol 4,5-biphosphate (PI(4,5)P₂) depletion. When PI(4,5)P₂...
Docosahexaenoic acid reduces adenosine triphosphate-induced calcium influx via inhibition of store-operated calcium channels and enhances baseline endothelial nitric oxide synthase phosphorylation in human endothelial cells

Vu TT, Dieterich , Vu TT, Deussen A

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):345-356.
  • doi: 10.4196/kjpp.2019.23.5.345
Docosahexaenoic acid (DHA), an omega-3-fatty acid, modulates multiple cellular functions. In this study, we addressed the effects of DHA on human umbilical vein endothelial cell calcium transient and endothelial nitric...
Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice

Park KA, Jin Z, An HS, Lee JY, Jeong EA, Choi EB, Kim KE, Shin HJ, Lee JE, Roh GS

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):335-344.
  • doi: 10.4196/kjpp.2019.23.5.335
Obesity causes inflammation and impairs thermogenic functions in brown adipose tissue (BAT). The adipokine lipocalin 2 (LCN2) has been implicated in inflammation and obesity. Herein, we investigated the protective effects...
Effect of gemigliptin on cardiac ischemia/reperfusion and spontaneous hypertensive rat models

Nam DH, Park J, Park SH, Kim KS, Baek EB

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):329-334.
  • doi: 10.4196/kjpp.2019.23.5.329
Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect...
Layer-specific cholinergic modulation of synaptic transmission in layer 2/3 pyramidal neurons of rat visual cortex

Cho KH, Lee SY, Joo K, Rhie DJ

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):317-328.
  • doi: 10.4196/kjpp.2019.23.5.317
It is known that top-down associative inputs terminate on distal apical dendrites in layer 1 while bottom-up sensory inputs terminate on perisomatic dendrites of layer 2/3 pyramidal neurons (L2/3 PyNs)...
Current status and future direction of digital health in Korea

Shin SY

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):311-315.
  • doi: 10.4196/kjpp.2019.23.5.311
Recently, digital health has gained the attention of physicians, patients, and healthcare industries. Digital health, a broad umbrella term, can be defined as an emerging health area that uses brand...
Toward a grey box approach for cardiovascular physiome

Hwang M, Leem CH, Shim EB

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):305-310.
  • doi: 10.4196/kjpp.2019.23.5.305
The physiomic approach is now widely used in the diagnosis of cardiovascular diseases. There are two possible methods for cardiovascular physiome: the traditional mathematical model and the machine learning (ML)...
Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart

Okada JI, Washio T, Sugiura S, Hisada T

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):295-303.
  • doi: 10.4196/kjpp.2019.23.5.295
A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and...
Digital heart for life

Zhang YH

  • Korean J Physiol Pharmacol.
  • 2019 Sep;23(5):291-293.
  • doi: 10.4196/kjpp.2019.23.5.291
No abstract available.

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