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Increased expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 after pilocarpine-induced status epilepticus in mice

Cho KO, Kim JY, Jeong KH, Lee MY, Kim SY

  • Korean J Physiol Pharmacol.
  • 2019 Jul;23(4):281-289.
  • doi: 10.4196/kjpp.2019.23.4.281
Vascular endothelial growth factor (VEGF)-C and its receptor, vascular endothelial growth factor receptor (VEGFR)-3, are responsible for lymphangiogenesis in both embryos and adults. In epilepsy, the expression of VEGF-C and...
Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice

Nguyen HT, Cho DH, Jang SH, Han SK, Park SJ

  • Korean J Physiol Pharmacol.
  • 2019 Jul;23(4):271-279.
  • doi: 10.4196/kjpp.2019.23.4.271
The lamina II, also called the substantia gelatinosa (SG), of the trigeminal subnucleus caudalis (Vc), is thought to play an essential role in the control of orofacial nociception. Glycine and...
Hepatoprotective effect of sodium hydrosulfide on hepatic encephalopathy in rats

Kwon KW, Nam Y, Choi WS, Kim TW, Kim GM, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2019 Jul;23(4):263-270.
  • doi: 10.4196/kjpp.2019.23.4.263
Hydrogen sulfide is well-known to exhibit anti-inflammatory and cytoprotective activities, and also has protective effects in the liver. This study aimed to examine the protective effect of hydrogen sulfide in...
Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice

Huang Q, Han L, Lv R, Ling L

  • Korean J Physiol Pharmacol.
  • 2019 Jul;23(4):251-261.
  • doi: 10.4196/kjpp.2019.23.4.251
Allergic asthma, is a common chronic inflammatory disease of the airway presenting with airway hyperresponsiveness and airway remodelling. T helper cells-derived cytokines are critically associated with asthma pathogenesis. Janus kinase-signal...
Imaging and analysis of genetically encoded calcium indicators linking neural circuits and behaviors

Oh J, Lee C, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2019 Jul;23(4):237-249.
  • doi: 10.4196/kjpp.2019.23.4.237
Confirming the direct link between neural circuit activity and animal behavior has been a principal aim of neuroscience. The genetically encoded calcium indicator (GECI), which binds to calcium ions and...
Potency and plasma protein binding of drugs in vitro—a potentially misleading pair for predicting in vivo efficacious concentrations in humans

Yim DS

  • Korean J Physiol Pharmacol.
  • 2019 Jul;23(4):231-236.
  • doi: 10.4196/kjpp.2019.23.4.231
In drug discovery or preclinical stages of development, potency parameters such as ICâ‚…â‚€, K(i), or K(d) in vitro have been routinely used to predict the parameters of efficacious exposure (AUC,...

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