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13 results

Inhibition of voltage-dependent K⁺ current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone

An JR, Li H, Seo MS, Park WS

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):597-605.
  • doi: 10.4196/kjpp.2018.22.5.597
In this study, we demonstrated the inhibitory effect of the Class Ic antiarrhythmic agent propafenone on voltage-dependent K⁺ (Kv) channels using freshly isolated coronary artery smooth muscle cells from rabbits....
Tricyclic antidepressant amitriptyline inhibits 5-hydroxytryptamine 3 receptor currents in NCB-20 cells

Park YS, Myeong SH, Kim IB, Sung KW

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):585-595.
  • doi: 10.4196/kjpp.2018.22.5.585
Amitriptyline, a tricyclic antidepressant, is commonly used to treat depression and neuropathic pain, but its mechanism is still unclear. We tested the effect of amitriptyline on 5-hydroxytryptamine 3 (5-HT₃) receptor...
The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats

Han JS, Min YS, Kim GH, Chae SH, Nam Y, Lee J, Lee SY, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):577-584.
  • doi: 10.4196/kjpp.2018.22.5.577
Bladder dysfunction is a common complication of diabetes mellitus (DM). However, there have been a few studies evaluating bladder smooth muscle contraction in DM in the presence of pharmacological inhibitors....
Carbon monoxide releasing molecule-2 protects mice against acute kidney injury through inhibition of ER stress

Uddin MJ, Pak ES, Ha H

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):567-575.
  • doi: 10.4196/kjpp.2018.22.5.567
Acute kidney injury (AKI), which is defined as a rapid decline of renal function, becomes common and recently recognized to be closely intertwined with chronic kidney diseases. Current treatment for...
Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth

Bak DH, Choi MJ, Kim SR, Lee BC, Kim JM, Jeon ES, Oh W, Lim ES, Park BC, Kim MJ, Na J, Kim BJ

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):555-566.
  • doi: 10.4196/kjpp.2018.22.5.555
Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) are used in tissue repair and regeneration; however, the mechanisms involved are not well understood. We investigated the hair growth-promoting effects of...
Antipruritic effect of curcumin on histamine-induced itching in mice

Lee HK, Park SB, Chang SY, Jung SJ

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):547-554.
  • doi: 10.4196/kjpp.2018.22.5.547
Itching is a common clinical symptom of skin disease that significantly affects a patient's quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers...
Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice

Jang SH, Park SJ, Lee CJ, Ahn DK, Han SK

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):539-546.
  • doi: 10.4196/kjpp.2018.22.5.539
Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus...
Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder

Lee B, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):525-538.
  • doi: 10.4196/kjpp.2018.22.5.525
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported...
Extracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via DR5 in gastric cancer cells

Hong R, Han SI

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):513-523.
  • doi: 10.4196/kjpp.2018.22.5.513
The tumor microenvironment greatly influences cancer cell characteristics, and acidic extracellular pH has been implicated as an essential factor in tumor malignancy and the induction of drug resistance. Here, we...
Lysophosphatidic acid enhances breast cancer cells-mediated osteoclastogenesis

Nam JS, Sharma AR, Nguyen LT, Jagga S, Lee YH, Sharma G, Lee SS

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):503-511.
  • doi: 10.4196/kjpp.2018.22.5.503
Lysophosphatidic acid (LPA) is known to play a critical role in breast cancer metastasis to bone. In this study, we tried to investigate any role of LPA in the regulation...
The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats

Safhi MM, Anwer T, Khan G, Siddiqui R, Moni Sivakumar S, Alam MF

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):493-501.
  • doi: 10.4196/kjpp.2018.22.5.493
The present study was carried out with the hypothesis that combination of canagliflozin and omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac biomarkers, inflammatory cytokines...
Influence of rutin on the effects of neonatal cigarette smoke exposure-induced exacerbated MMP-9 expression, Th17 cytokines and NF-κB/iNOS-mediated inflammatory responses in asthmatic mice model

Liu LL, Zhang Y, Zhang XF, Li FH

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):481-491.
  • doi: 10.4196/kjpp.2018.22.5.481
Allergic asthma is one of the most enduring diseases of the airway. The T-helper cells and regulatory T-cells are critically involved in inflammatory responses, mucus hypersecretion, airway remodelling and in...
Conditioning-induced cardioprotection: Aging as a confounding factor

Randhawa P, Bali A, Virdi JK, Jaggi AS

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):467-479.
  • doi: 10.4196/kjpp.2018.22.5.467
The aging process induces a plethora of changes in the body including alterations in hormonal regulation and metabolism in various organs including the heart. Aging is associated with marked increase...

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