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13 results

Regional difference in spontaneous firing inhibition by GABA(A) and GABA(B) receptors in nigral dopamine neurons

Kim Y, Jang J, Kim HJ, Park MK

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):721-729.
  • doi: 10.4196/kjpp.2018.22.6.721
GABAergic control over dopamine (DA) neurons in the substantia nigra is crucial for determining firing rates and patterns. Although GABA activates both GABA(A) and GABA(B) receptors distributed throughout the somatodendritic...
Potentiation of endothelium-dependent vasorelaxation of mesenteric arteries from spontaneously hypertensive rats by gemigliptin, a dipeptidyl peptidase-4 inhibitor class of anti-diabetic drug

Kim HJ, Baek EB, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):713-719.
  • doi: 10.4196/kjpp.2018.22.6.713
Dipeptidyl peptidase4 (DPP4) inhibitors such as gemigliptin are anti-diabetic drugs elevating plasma concentration of incretins such as GLP-1. In addition to the DPP4 inhibition, gemigliptin might directly improve the functions...
Advanced tube formation assay using human endothelial colony forming cells for in vitro evaluation of angiogenesis

Lee H, Kang KT

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):705-712.
  • doi: 10.4196/kjpp.2018.22.6.705
The tube formation assay is a widely used in vitro experiment model to evaluate angiogenic properties by measuring the formation of tubular structures from vascular endothelial cells (ECs). in vitro...
Mitochondrial dysfunction reduces the activity of KIR2.1 K⁺ channel in myoblasts via impaired oxidative phosphorylation

Woo J, Kim HJ, Nam YR, Kim YK, Lee EJ, Choi I, Kim SJ, Lee W, Nam JH

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):697-703.
  • doi: 10.4196/kjpp.2018.22.6.697
Myoblast fusion depends on mitochondrial integrity and intracellular Ca²⁺ signaling regulated by various ion channels. In this study, we investigated the ionic currents associated with [Ca²⁺]i regulation in normal and...
Cyanidin-3-glucoside inhibits amyloid β₂₅₋₃₅-induced neuronal cell death in cultured rat hippocampal neurons

Yang JS, Jeon S, Yoon KD, Yoon SH

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):689-696.
  • doi: 10.4196/kjpp.2018.22.6.689
Increasing evidence implicates changes in [Ca²⁺]i and oxidative stress as causative factors in amyloid beta (Aβ)-induced neuronal cell death. Cyanidin-3-glucoside (C3G), a component of anthocyanin, has been reported to protect...
Dual mechanisms for the regulation of brain-derived neurotrophic factor by valproic acid in neural progenitor cells

Ko HM, Jin Y, Park HH, Lee JH, Jung SH, Choi SY, Lee SH, Shin CY

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):679-688.
  • doi: 10.4196/kjpp.2018.22.6.679
Autism spectrum disorders (ASDs) are neurodevelopmental disorders that share behavioral features, the results of numerous studies have suggested that the underlying causes of ASDs are multifactorial. Behavioral and/or neurobiological analyses...
Tussilagone suppressed the production and gene expression of MUC5AC mucin via regulating nuclear factor-kappa B signaling pathway in airway epithelial cells

Choi BS, Kim YJ, Yoon YP, Lee HJ, Lee CJ

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):671-677.
  • doi: 10.4196/kjpp.2018.22.6.671
In the present study, we investigated whether tussilagone, a natural product derived from Tussilago farfara, significantly affects the production and gene expression of airway MUC5AC mucin. Confluent NCI-H292 cells were...
Fimasartan attenuates renal ischemia-reperfusion injury by modulating inflammation-related apoptosis

Cho JH, Choi SY, Ryu HM, Oh EJ, Yook JM, Ahn JS, Jung HY, Choi JY, Park SH, Kim CD, Kim YL

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):661-670.
  • doi: 10.4196/kjpp.2018.22.6.661
Fimasartan, a new angiotensin II receptor antagonist, reduces myocyte damage and stabilizes atherosclerotic plaque through its anti-inflammatory effect in animal studies. We investigated the protective effects of pretreatment with fimasartan...
Effect of carbamazepine on tetrodotoxin-resistant Na⁺ channels in trigeminal ganglion neurons innervating to the dura

Han JE, Cho JH, Nakamura M, Lee MG, Jang IS

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):649-660.
  • doi: 10.4196/kjpp.2018.22.6.649
Migraine is a neurological disorder characterized by recurrent and disabling severe headaches. Although several anticonvulsant drugs that block voltage-dependent Na⁺ channels are widely used for migraine, far less is known...
The treatment effect of novel hGHRH homodimer to male infertility hamster

Zhang XD, Guo XY, Tang JX, Yue LN, Zhang JH, Liu T, Dong YX, Tang SS

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):637-647.
  • doi: 10.4196/kjpp.2018.22.6.637
Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in reproduction. To study the treatment effect of Grin (a novel hGHRH homodimer), the infertility models of 85 male Chinese hamsters...
6-Shogaol reduces progression of experimental endometriosis in vivo and in vitro via regulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses

Wang D, Jiang Y, Yang X, Wei Q, Wang H

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):627-636.
  • doi: 10.4196/kjpp.2018.22.6.627
Endometriosis (EM) is one of the most common gynaecological disorder affecting women in their reproductive age. Mechanisms involved in the pathogenesis of EM remains poorly understood, however inflammatory responses have...
The Nedd8-activating enzyme inhibitor MLN4924 suppresses colon cancer cell growth via triggering autophagy

Lv Y, Li B, Han K, Xiao Y, Yu X, Ma Y, Jiao Z, Gao J

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):617-625.
  • doi: 10.4196/kjpp.2018.22.6.617
Neddylation is a post-translational protein modification process. MLN4924 is a newly discovered pharmaceutical neddylation inhibitor that suppresses cancer growth with several cancer types. In our study, we first investigated the...
The effect of melatonin on cardio fibrosis in juvenile rats with pressure overload and deregulation of HDACs

Wu Y, Si F, Luo L, Jing F, Jiang K, Zhou J, Yi Q

  • Korean J Physiol Pharmacol.
  • 2018 Nov;22(6):607-616.
  • doi: 10.4196/kjpp.2018.22.6.607
The effect of melatonin on juveniles with cardio fibrosis is poorly understood. We investigated whether HDACs participate in the anti-fibrotic processes regulated by melatonin during hypertrophic remodeling. Abdominal aortic constriction...

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