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14 results

Corrigendum to: Effects of salmon DNA fraction in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model

Ra HJ, Oh MY, Kim HJ, Lee SY, Eom DW, Lee SK, Kim SN, Chung KS, Jang HJ

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):361-361.
  • doi: 10.4196/kjpp.2018.22.3.361
The authors note that on pages 167 (Fig. 2A), 168 (Fig. 3A), and 169 (Fig. 4A), the figure label “RPF-001” should instead appear as “PRF-001.”
Anti-apoptotic effects of autophagy via ROS regulation in microtubule-targeted and PDGF-stimulated vascular smooth muscle cells

Park HS, Han JH, Jung SH, Lee DH, Heo KS, Myung CS

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):349-360.
  • doi: 10.4196/kjpp.2018.22.3.349
Autophagy has been studied as a therapeutic strategy for cardiovascular diseases. However, insufficient studies have been reported concerning the influence of vascular smooth muscle cells (VSMCs) through autophagy regulation. The...
Increased store-operated Ca²⁺ entry mediated by GNB5 and STIM1

Kang N, Kang JY, Park S, Shin DM

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):343-348.
  • doi: 10.4196/kjpp.2018.22.3.343
Recent human genetic studies have shown that Gβ5 is related to various clinical symptoms, such as sinus bradycardia, cognitive disability, and attention deficit hyperactivity disorder. Although the calcium signaling cascade...
Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats

Yoon JH, Son JY, Kim MJ, Kang SH, Ju JS, Bae YC, Ahn DK

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):331-341.
  • doi: 10.4196/kjpp.2018.22.3.331
The aim of the present study was to examine the effects of preemptive analgesia on the development of trigeminal neuropathic pain. For this purpose, mechanical allodynia was evaluated in male...
Physiologically-based pharmacokinetic predictions of intestinal BCRP-mediated drug interactions of rosuvastatin in Koreans

Bae SH, Park WS, Han S, Park GJ, Lee J, Hong T, Jeon S, Yim DS

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):321-329.
  • doi: 10.4196/kjpp.2018.22.3.321
It was recently reported that the C(max) and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3,...
Nobiletin attenuates neurotoxic mitochondrial calcium overload through K⁺ influx and ΔΨ(m) across mitochondrial inner membrane

Lee JH, Amarsanaa , Wu J, Jeon SC, Cui Y, Jung SC, Park DB, Kim SJ, Han SH, Kim HW, Rhyu IJ, Eun SY

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):311-319.
  • doi: 10.4196/kjpp.2018.22.3.311
Mitochondrial calcium overload is a crucial event in determining the fate of neuronal cell survival and death, implicated in pathogenesis of neurodegenerative diseases. One of the driving forces of calcium...
Atorvastatin pretreatment attenuates kainic acid-induced hippocampal neuronal death via regulation of lipocalin-2-associated neuroinflammation

Jin Z, Jung Y, Yi CO, Lee JY, Jeong EA, Lee JE, Park KJ, Kwon OY, Lim BH, Choi NC, Roh GS

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):301-309.
  • doi: 10.4196/kjpp.2018.22.3.301
Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism...
Establishment and evaluation of the VX2 orthotopic lung cancer rabbit model: a ultra-minimal invasive percutaneous puncture inoculation method

Wang L, Che K, Liu Z, Huang X, Xiang S, Zhu F, Yu Y

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):291-300.
  • doi: 10.4196/kjpp.2018.22.3.291
The purpose of the present work is to establish an ultra-minimal invasive percutaneous puncture inoculation method for a VX2 orthotopic lung cancer rabbit model with fewer technical difficulties, lower mortality...
Exposure to 835 MHz RF-EMF decreases the expression of calcium channels, inhibits apoptosis, but induces autophagy in the mouse hippocampus

Kim JH, Sohn UD, Kim HG, Kim HR

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):277-289.
  • doi: 10.4196/kjpp.2018.22.3.277
The exponential increase in the use of mobile communication has triggered public concerns about the potential adverse effects of radiofrequency electromagnetic fields (RF-EMF) emitted by mobile phones on the central...
Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model

Lei X, Cai L, Li X, Xu H, Geng C, Wang C

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):269-275.
  • doi: 10.4196/kjpp.2018.22.3.269
Na⁺/H⁺ exchangers (NHEs) have been shown to be involved in regulating cell volume and maintaining fluid and electrolyte homeostasis. Pooled evidences have suggested that loss of Na⁺/H⁺ exchanger isoform 8...
Effects of cinnamic acid on memory deficits and brain oxidative stress in streptozotocin-induced diabetic mice

Hemmati AA, Alboghobeish S, Ahangarpour A

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):257-267.
  • doi: 10.4196/kjpp.2018.22.3.257
The present study aimed to evaluate the cinnamic acid effect on memory impairment, oxidative stress, and cholinergic dysfunction in streptozotocin (STZ)-induced diabetic model in mice. In this experimental study, 48...
Echinacoside, an active constituent of Herba Cistanche, suppresses epileptiform activity in hippocampal CA3 pyramidal neurons

Lu CW, Huang SK, Lin TY, Wang SJ

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):249-255.
  • doi: 10.4196/kjpp.2018.22.3.249
Echinacoside, an active compound in the herb Herba Cistanche, has been reported to inhibit glutamate release. In this study, we investigated the effects of echinacoside on spontaneous excitatory synaptic transmission...
Ursolic acid in health and disease

Seo DY, Lee SR, Heo JW, No MH, Rhee BD, Ko KS, Kwak HB, Han J

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):235-248.
  • doi: 10.4196/kjpp.2018.22.3.235
Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. There is a growing interest in UA because of its beneficial effects, which include anti-inflammatory, anti-oxidant,...
Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection

Singh L, Kulshrestha R, Singh N, Jaggi AS

  • Korean J Physiol Pharmacol.
  • 2018 May;22(3):225-234.
  • doi: 10.4196/kjpp.2018.22.3.225
Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic...

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