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Hydrogen peroxide inhibits Ca²⁺ efflux through plasma membrane Ca²⁺-ATPase in mouse parotid acinar cells

Kim MJ, Choi KJ, Yoon MN, Oh SH, Kim DK, Kim SH, Park HS

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):215-223.
  • doi: 10.4196/kjpp.2018.22.2.215
Intracellular Ca²⁺ mobilization is closely linked with the initiation of salivary secretion in parotid acinar cells. Reactive oxygen species (ROS) are known to be related to a variety of oxidative...
Hypoxia-dependent mitochondrial fission regulates endothelial progenitor cell migration, invasion, and tube formation

Kim DY, Jung SY, Kim YJ, Kang S, Park JH, Ji ST, Jang WB, Lamichane , Lamichane , Chae YC, Lee D, Chung JS, Kwon SM

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):203-213.
  • doi: 10.4196/kjpp.2018.22.2.203
Tumor undergo uncontrolled, excessive proliferation leads to hypoxic microenvironment. To fulfill their demand for nutrient, and oxygen, tumor angiogenesis is required. Endothelial progenitor cells (EPCs) have been known to the...
Fluvastatin inhibits advanced glycation end products-induced proliferation, migration, and extracellular matrix accumulation in vascular smooth muscle cells by targeting connective tissue growth factor

Hwang AR, Nam JO, Kang YJ

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):193-201.
  • doi: 10.4196/kjpp.2018.22.2.193
Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects...
Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder

Lee B, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):183-192.
  • doi: 10.4196/kjpp.2018.22.2.183
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear...
Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons

Han RT, Kim HB, Kim YB, Choi K, Park GY, Lee PR, Lee J, Kim HY, Park CK, Kang Y, Oh SB, Na HS

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):173-182.
  • doi: 10.4196/kjpp.2018.22.2.173
Recent studies have provided several lines of evidence that peripheral administration of oxytocin induces analgesia in human and rodents. However, the exact underlying mechanism of analgesia still remains elusive. In...
Effects of salmon DNA fraction in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model

Ra HJ, Oh MY, Kim HJ, Lee SY, Eom DW, Lee SK, Kim SN, Chung KS, Jang HJ

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):163-172.
  • doi: 10.4196/kjpp.2018.22.2.163
PRF001 is a fragmented DNA polymer extracted from the testes of salmon. The purpose of this study was to assess the anti-inflammatory effect of PRF001 in vitro as well as...
The antidepressant action of 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid is mediated by phosphorylation of histone deacetylase 5

Park MH, Choi M, Kim YS, Son H

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):155-162.
  • doi: 10.4196/kjpp.2018.22.2.155
3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant-like effects in animal models of depression. However, the molecular mechanisms underlying these behavioral actions remain unknown. Here, we...
Toll-like receptor 2 promotes neurogenesis from the dentate gyrus after photothrombotic cerebral ischemia in mice

Seong KJ, Kim HJ, Cai B, Kook MS, Jung JY, Kim WJ

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):145-153.
  • doi: 10.4196/kjpp.2018.22.2.145
The subgranular zone (SGZ) of hippocampal dentate gyrus (HDG) is a primary site of adult neurogenesis. Toll-like receptors (TLRs), are involved in neural system development of Drosophila and innate immune...
Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells

Bae EH, Kim IJ, Choi HS, Kim HY, Kim CS, Ma SK, Kim IS, Kim SW

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):135-143.
  • doi: 10.4196/kjpp.2018.22.2.135
Tumor necrosis factor-α (TNFα) and the angiotensin system are involved in inflammatory diseases and may contribute to acute kidney injury. We investigated the mechanisms by which TNFα-converting enzyme (TACE) contributes...
Silencing MR-1 attenuates atherosclerosis in ApoE(−/−) mice induced by angiotensin II through FAK-Akt–mTOR-NF-kappaB signaling pathway

Chen Y, Cao J, Zhao Q, Luo H, Wang Y, Dai W

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):127-134.
  • doi: 10.4196/kjpp.2018.22.2.127
Myofibrillogenesis regulator-1 (MR-1) is a novel protein involved in cellular proliferation, migration, inflammatory reaction and signal transduction. However, little information is available on the relationship between MR-1 expression and the...
The potential theragnostic (diagnostic+therapeutic) application of exosomes in diverse biomedical fields

Kim YS, Ahn JS, Kim S, Kim HJ, Kim SH, Kang JS

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):113-125.
  • doi: 10.4196/kjpp.2018.22.2.113
Exosomes are membranous vesicles of 30-150 nm in diameter that are derived from the exocytosis of the intraluminal vesicles of many cell types including immune cells, stem cells, cardiovascular cells...

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