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11 results

Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice

Hwang SA, Kim CD, Lee WS

  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):101-110.
  • doi: 10.4196/kjpp.2018.22.1.101
In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury...
Functional identification of protein phosphatase 1-binding consensus residues in NBCe1-B

Lee KP, Kim HJ, Yang D

  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):91-99.
  • doi: 10.4196/kjpp.2018.22.1.91
Protein phosphatase 1 (PP1) is involved in various signal transduction mechanisms as an extensive regulator. The PP1 catalytic subunit (PP1c) recognizes and binds to PP1-binding consensus residues (FxxR/KxR/K) in NBCe1-B....
Inhibitory effects of 2,6-di-tert-butyl-4-hydroxymethylphenol on asthmatic responses to ovalbumin challenge in conscious guinea pigs

Jeong SY, Lee JY

  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):81-89.
  • doi: 10.4196/kjpp.2018.22.1.81
This study evaluated the anti-asthmatic activities of 2,6-di-tert-butyl-4-hydroxymethylphenol (DBHP) that is a potent phenolic antioxidant in edible vegetable oil. The effects of DBHP on bronchial asthma were evaluated by determining...
Antidepressant drug paroxetine blocks the open pore of Kv3.1 potassium channel

Lee HM, Chai OH, Hahn SJ, Choi BH

  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):71-80.
  • doi: 10.4196/kjpp.2018.22.1.71
In patients with epilepsy, depression is a common comorbidity but difficult to be treated because many antidepressants cause pro-convulsive effects. Thus, it is important to identify the risk of seizures...
Cilostazol attenuates kainic acid-induced hippocampal cell death

Park YS, Jin Z, Jeong EA, Yi CO, Lee JY, Park IS, Roh GS

  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):63-70.
  • doi: 10.4196/kjpp.2018.22.1.63
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate...
Ethyl linoleate inhibits α-MSH-induced melanogenesis through Akt/GSK3β/β-catenin signal pathway

Ko GA, Kim Cho S

  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):53-61.
  • doi: 10.4196/kjpp.2018.22.1.53
Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent....
Epigenetic modification of α-N-acetylgalactosaminidase enhances cisplatin resistance in ovarian cancer

Ha YN, Sung HY, Yang SD, Chae YJ, Ju W, Ahn JH

  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):43-51.
  • doi: 10.4196/kjpp.2018.22.1.43
Although cisplatin is one of the most effective antitumor drugs for ovarian cancer, the emergence of chemoresistance to cisplatin in over 80% of initially responsive patients is a major barrier...
Alleviation of ascorbic acid-induced gastric high acidity by calcium ascorbate in vitro and in vivo

Lee JK, Jung SH, Lee SE, Han JH, Jo E, Park HS, Heo KS, Kim D, Park JS, Myung CS

  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):35-42.
  • doi: 10.4196/kjpp.2018.22.1.35
Ascorbic acid is one of the most well-known nutritional supplement and antioxidant found in fruits and vegetables. Calcium ascorbate has been developed to mitigate the gastric irritation caused by the...
Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome

Kim M, Lee HA, Cho HM, Kang SH, Lee E, Kim IK

  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):23-33.
  • doi: 10.4196/kjpp.2018.22.1.23
Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors...
Morroniside on anti-inflammation activities in rats following acute myocardial infarction

Yu B, Zhang G, An Y, Wang W

  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):17-21.
  • doi: 10.4196/kjpp.2018.22.1.17
Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and...
Role of inflammasomes in inflammatory autoimmune rheumatic diseases


  • Korean J Physiol Pharmacol.
  • 2018 Jan;22(1):1-15.
  • doi: 10.4196/kjpp.2018.22.1.1
Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of...

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