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Developmental changes in GABAA tonic inhibition are compromised by multiple mechanisms in preadolescent dentate gyrus granule cells

Pandit S, Lee GS, Park JB

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):695-702.
  • doi: 10.4196/kjpp.2017.21.6.695
The sustained tonic currents (I(tonic)) generated by γ-aminobutyric acid A receptors (GABA(A)Rs) are implicated in diverse age-dependent brain functions. While various mechanisms regulating I(tonic) in the hippocampus are known, their...
Biphasic augmentation of alpha-adrenergic contraction by plumbagin in rat systemic arteries

Kim HJ, Yoo HY, Zhang YH, Kim WK, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):687-694.
  • doi: 10.4196/kjpp.2017.21.6.687
Plumbagin, a hydroxy 1,4-naphthoquinone compound from plant metabolites, exhibits anticancer, antibacterial, and antifungal activities via modulating various signaling molecules. However, its effects on vascular functions are rarely studied except in...
Dual control of the vestibulosympathetic reflex following hypotension in rats

Park SE, Jin YZ, Park BR

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):675-686.
  • doi: 10.4196/kjpp.2017.21.6.675
Orthostatic hypotension (OH) is associated with symptoms including headache, dizziness, and syncope. The incidence of OH increases with age. Attenuation of the vestibulosympathetic reflex (VSR) is also associated with an...
Comparative effects of angiotensin II and angiotensin-(4-8) on blood pressure and ANP secretion in rats

Phuong HT, Yu L, Park BM, Kim SH

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):667-674.
  • doi: 10.4196/kjpp.2017.21.6.667
Angiotensin II (Ang II) is metabolized from N-terminal by aminopeptidases and from C-terminal by Ang converting enzyme (ACE) to generate several truncated angiotensin peptides (Angs). The truncated Angs have different...
The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain

Kim MJ, Lee JH, Jang JU, Quan FS, Kim SK, Kim W

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):657-666.
  • doi: 10.4196/kjpp.2017.21.6.657
Paclitaxel, a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic...
Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study

Bang HS, Seo DY, Chung YM, Kim DH, Lee SJ, Lee SR, Kwak HB, Kim TN, Kim M, Oh KM, Son YJ, Kim S, Han J

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):651-656.
  • doi: 10.4196/kjpp.2017.21.6.651
Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial...
Chronic cerebral hypoperfusion and plasticity of the posterior cerebral artery following permanent bilateral common carotid artery occlusion

Cho KO, Kim SK, Kim SY

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):643-650.
  • doi: 10.4196/kjpp.2017.21.6.643
Vascular dementia (VaD) is a group of heterogeneous diseases with the common feature of cerebral hypoperfusion. To identify key factors contributing to VaD pathophysiology, we performed a detailed comparison of...
Effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and endoplasmic reticulum stress of the cardiac muscle in obese middle-aged rats

Kim K, Ahn N, Jung S, Park S

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):633-641.
  • doi: 10.4196/kjpp.2017.21.6.633
The aim of this study is to investigate the effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and ER stress of the cardiac muscle in high fat diet-induced obese...
MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation

Lee S, Oh ST, Jeong HJ, Pak SC, Park HJ, Kim J, Cho HS, Jeon S

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):625-632.
  • doi: 10.4196/kjpp.2017.21.6.625
Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this...
Taurine relaxes human radial artery through potassium channel opening action

Ulusoy KG, Kaya E, Karabacak , Seyrek M, Duvan I, Yildirim V, Yildiz O

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):617-623.
  • doi: 10.4196/kjpp.2017.21.6.617
The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First,...
Ardipusilloside-I stimulates gastrointestinal motility and phosphorylation of smooth muscle myosin by myosin light chain kinase

Xu Z, Liang H, Zhang M, Tao X, Dou D, Hu L, Kang T

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):609-616.
  • doi: 10.4196/kjpp.2017.21.6.609
Ardipusilloside-I is a natural triterpenoid saponin, which was isolated from Ardisia pusilla A. DC. The aim of the study was to evaluate the stimulation of ardipusilloside-I on gastrointestinal motility in...
JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells

Choi DW, Kim DK, Kanai Y, Wempe MF, Endou H, Kim JK

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):599-607.
  • doi: 10.4196/kjpp.2017.21.6.599
Most normal cells express L-type amino acid transporter 2 (LAT2). However, L-type amino acid transporter 1 (LAT1) is highly expressed in many tumor cells and presumed to support their increased...
The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery

Hao N, Zhaojun W, Kuang S, Zhang G, Deng C, Ma J, Cui J

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):591-598.
  • doi: 10.4196/kjpp.2017.21.6.591
Propofol is known to cause vasorelaxation of several systemic vascular beds. However, its effect on the pulmonary vasculature remains controversial. In the present study, we investigated the effects of propofol...
Genistein attenuates isoflurane-induced neurotoxicity and improves impaired spatial learning and memory by regulating cAMP/CREB and BDNF-TrkB-PI3K/Akt signaling

Jiang T, Wang XQ, Ding C, Du XL

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):579-589.
  • doi: 10.4196/kjpp.2017.21.6.579
Anesthetics are used extensively in surgeries and related procedures to prevent pain. However, there is some concern regarding neuronal degeneration and cognitive deficits arising from regular anesthetic exposure. Recent studies...
Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle

Heo JW, No MH, Park DH, Kang JH, Seo DY, Han J, Neufer PD, Kwak HB

  • Korean J Physiol Pharmacol.
  • 2017 Nov;21(6):567-577.
  • doi: 10.4196/kjpp.2017.21.6.567
Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all associated with mitochondrial dysfunction in skeletal muscle....

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