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10 results

Expression profile of mitochondrial voltage-dependent anion channel-1 (VDAC1) influenced genes is associated with pulmonary hypertension

Zhou T, Tang H, Han Y, Fraidenburg D, Kim YW, Lee D, Choi J, Bang H, Ko JH

  • Korean J Physiol Pharmacol.
  • 2017 May;21(3):353-360.
  • doi: 10.4196/kjpp.2017.21.3.353
Several human diseases have been associated with mitochondrial voltage-dependent anion channel-1 (VDAC1) due to its role in calcium ion transportation and apoptosis. Recent studies suggest that VDAC1 may interact with...
JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38

Yi YS, Kim MY, Cho JY

  • Korean J Physiol Pharmacol.
  • 2017 May;21(3):345-352.
  • doi: 10.4196/kjpp.2017.21.3.345
Since previous studies have reported that hydroquinone (HQ) exerted immunosuppressive and anti-inflammatory activity, various HQ derivatives have been synthesized and their biological activities investigated. In this study, we explored the...
Therapeutic effects of orally administered CJLP55 for atopic dermatitis via the regulation of immune response

Hyung KE, Kim SJ, Jang YW, Lee DK, Hyun KH, Moon BS, Kim B, Ahn H, Park SY, Sohn UD, Park ES, Hwang KW

  • Korean J Physiol Pharmacol.
  • 2017 May;21(3):335-343.
  • doi: 10.4196/kjpp.2017.21.3.335
Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study,...
Dust particles-induced intracellular Ca²⁺ signaling and reactive oxygen species in lung fibroblast cell line MRC5

Lee DU, Ji MJ, Kang JY, Kyung SY, Hong JH

  • Korean J Physiol Pharmacol.
  • 2017 May;21(3):327-334.
  • doi: 10.4196/kjpp.2017.21.3.327
Epidemiologic interest in particulate matter (PM) is growing particularly because of its impact of respiratory health. It has been elucidated that PM evoked inflammatory signal in pulmonary epithelia. However, it...
Endogenous catalase delays high-fat diet-induced liver injury in mice

Piao L, Choi J, Kwon G, Ha H

  • Korean J Physiol Pharmacol.
  • 2017 May;21(3):317-325.
  • doi: 10.4196/kjpp.2017.21.3.317
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in parallel with worldwide epidemic of obesity. Reactive oxygen species (ROS) contributes to the development and progression of...
Activation of transient receptor potential vanilloid 3 by the methanolic extract of Schisandra chinensis fruit and its chemical constituent γ-schisandrin

Nam Y, Kim HJ, Kim YM, Chin YW, Kim YK, Bae HS, Nam JH, Kim WK

  • Korean J Physiol Pharmacol.
  • 2017 May;21(3):309-316.
  • doi: 10.4196/kjpp.2017.21.3.309
Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel with modest permeability to calcium ions. It is involved in intracellular calcium signaling and is therefore important in processes...
PI3K and ERK signaling pathways are involved in differentiation of monocytic cells induced by 27-hydroxycholesterol

Son Y, Kim BY, Park YC, Eo SK, Cho HR, Kim K

  • Korean J Physiol Pharmacol.
  • 2017 May;21(3):301-308.
  • doi: 10.4196/kjpp.2017.21.3.301
27-Hydroxycholesterol induces differentiation of monocytic cells into mature dendritic cells, mDCs. In the current study we sought to determine roles of the PI3K and the ERK pathways in the 27OHChol-induced...
Peroxisome proliferator-activated receptor γ is essential for secretion of ANP induced by prostaglandin D₂ in the beating rat atrium

Zhang Y, Li X, Liu LP, Hong L, Liu X, Zhang B, Wu CZ, Cui X

  • Korean J Physiol Pharmacol.
  • 2017 May;21(3):293-300.
  • doi: 10.4196/kjpp.2017.21.3.293
Prostaglandin Dâ‚‚ (PGDâ‚‚) may act against myocardial ischemia-reperfusion (I/R) injury and play an anti-inflammatory role in the heart. Although the effect of PGDâ‚‚ in regulation of ANP secretion of the...
Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro

Xu P, Chen J, Tan C, Lai RS, Min ZS

  • Korean J Physiol Pharmacol.
  • 2017 May;21(3):287-292.
  • doi: 10.4196/kjpp.2017.21.3.287
Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle...
Identification of AMPK activator from twelve pure compounds isolated from Aralia Taibaiensis: implication in antihyperglycemic and hypolipidemic activities

Li Y, Park J, Wu Y, Cui J, Jia N, Xi M, Wen A

  • Korean J Physiol Pharmacol.
  • 2017 May;21(3):279-286.
  • doi: 10.4196/kjpp.2017.21.3.279
The root bark extract of Aralia taibaiensis is used traditionally for the treatment of diabetes mellitus in China. The total saponin extracted from Aralia Taibaiensis (sAT) has effective combined antihyperglycemic...

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