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Beauvericin, a cyclic peptide, inhibits inflammatory responses in macrophages by inhibiting the NF-κB pathway

Yoo S, Kim MY, Cho JY

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):449-456.
  • doi: 10.4196/kjpp.2017.21.4.449
Beauvericin (BEA), a cyclic hexadepsipeptide produced by the fungus Beauveria bassiana, is known to have anti-cancer, anti-inflammatory, and anti-microbial actions. However, how BEA suppresses macrophage-induced inflammatory responses has not been...
Electrophysiological characteristics of R47W and A298T mutations in CLC-1 of myotonia congenita patients and evaluation of clinical features

Chin HJ, Kim CH, Ha K, Shin JH, Kim DS, So I

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):439-447.
  • doi: 10.4196/kjpp.2017.21.4.439
Myotonia congenita (MC) is a genetic disease that displays impaired relaxation of skeletal muscle and muscle hypertrophy. This disease is mainly caused by mutations of CLCN1 that encodes human skeletal...
Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus

Muñoz-Pérez VM, Fernández-Martínez E, Ponce-Monter H, Ortiz MI

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):429-437.
  • doi: 10.4196/kjpp.2017.21.4.429
The aim of this study was to evaluate the relaxant and anti-inflammatory effects of two thalidomide analogs as phosphodiesterase-4 (PDE-4) inhibitors in pregnant rat uterus. Uteri from Wistar female rats...
Reduction of long-term potentiation at Schaffer collateral-CA1 synapses in the rat hippocampus at the acute stage of vestibular compensation

Lee GW, Kim JH, Kim MS

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):423-428.
  • doi: 10.4196/kjpp.2017.21.4.423
Vestibular compensation is a recovery process from vestibular symptoms over time after unilateral loss of peripheral vestibular end organs. The aim of the present study was to observe time-dependent changes...
Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K⁻ channels in coronary arterial smooth muscle cells

Kim HS, Li H, Kim HW, Shin SE, Seo MS, An JR, Ha KS, Han ET, Hong SH, Choi IW, Choi G, Lee DS, Park WS

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):415-421.
  • doi: 10.4196/kjpp.2017.21.4.415
We investigated the inhibitory effect of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K⁺ (Kv) channels in freshly separated from rabbit coronary arterial smooth muscle cells. The application...
Participation of COX-1 and COX-2 in the contractile effect of phenylephrine in prepubescent and old rats

Guevara-Balcazar G, Ramirez-Sanchez I, Mera-Jimenez E, Rubio-Gayosso I, Aguilar-Najera ME, Castillo-Hernandez MC

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):407-413.
  • doi: 10.4196/kjpp.2017.21.4.407
Vascular reactivity can be influenced by the vascular region, animal age, and pathologies present. Prostaglandins (produced by COX-1 and COX-2) play an important role in the contractile response to phenylephrine...
MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation

Lim SC, Han SI

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):397-405.
  • doi: 10.4196/kjpp.2017.21.4.397
MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell...
Elucidation of the profound antagonism of contractile action of phenylephrine in rat aorta effected by an atypical sympathomimetic decongestant

Rizvić E, Janković , Savić MM

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):385-395.
  • doi: 10.4196/kjpp.2017.21.4.385
Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decongestants and possible source of adverse responses. Insufficiently substantiated practice of combining decongestants in some marketed preparations,...
Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells

Joo HK, Lee YR, Choi S, Park MS, Kang G, Kim CS, Jeon BH

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):377-384.
  • doi: 10.4196/kjpp.2017.21.4.377
Activation of protein kinase C (PKC) is closely linked with endothelial dysfunction. However, the effect of PKCβII on endothelial dysfunction has not been characterized in cultured endothelial cells. Here, using...
Reactive oxygen species increase neuronal excitability via activation of nonspecific cation channel in rat medullary dorsal horn neurons

Lee HI, Park BR, Chun SW

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):371-376.
  • doi: 10.4196/kjpp.2017.21.4.371
The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) receives direct inputs from small diameter primary afferent fibers that predominantly transmit nociceptive information in the orofacial region....
Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model

Lee H, Im J, Won H, Nam W, Kim YO, Lee SW, Lee S, Cho IH, Kim HK, Kwon JT, Kim HJ

  • Korean J Physiol Pharmacol.
  • 2017 Jul;21(4):361-370.
  • doi: 10.4196/kjpp.2017.21.4.361
Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been...

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