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17 results

Corrigendum to: Gintonin facilitates catecholamine secretion from the perfused adrenal medulla

Na SY, Kim KH, Choi MS, Ha KS, Lim DY

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):141-141.
  • doi: 10.4196/kjpp.2017.21.1.141
The original version of this article contained misspelled name of authors. The name of Seung-Yeol Na is replaced with Seung-Yeol Nah. The name of Mi-Sung Choi is replaced with Mee-Sung...
Calcium permeability of transient receptor potential canonical (TRPC) 4 channels measured by TRPC4-GCaMP6s

Ko J, Myeong J, Yang D, So I

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):133-140.
  • doi: 10.4196/kjpp.2017.21.1.133
Conflicting evidence has been obtained regarding whether transient receptor potential cation channels (TRPC) are store-operated channels (SOCs) or receptor-operated channels (ROCs). Moreover, the Ca/Na permeability ratio differs depending on whether...
Neuroprotective effect of lithium after pilocarpine-induced status epilepticus in mice

Hong N, Choi YS, Kim SY, Kim HJ

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):125-131.
  • doi: 10.4196/kjpp.2017.21.1.125
Status epilepticus is the most common serious neurological condition triggered by abnormal electrical activity, leading to severe and widespread cell loss in the brain. Lithium has been one of the...
Inhibition of ERK1/2 by silymarin in mouse mesangial cells

Youn CK, Cho SI, Lee MY, Jeon YJ, Lee SK

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):117-124.
  • doi: 10.4196/kjpp.2017.21.1.117
The present study aimed to show that pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-1β] synergistically induce the production of nitric oxide (NO) production in mouse mesangial...
Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin

Park MH, Shin SH, Byeon JJ, Lee GH, Yu BY, Shin YG

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):107-115.
  • doi: 10.4196/kjpp.2017.21.1.107
Over the last decade, physiologically based pharmacokinetics (PBPK) application has been extended significantly not only to predicting preclinical/human PK but also to evaluating the drug-drug interaction (DDI) liability at the...
High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17

Kim JI

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):99-106.
  • doi: 10.4196/kjpp.2017.21.1.99
Obesity is a critical risk factor for the hypertension. Although angiotensin II (Ang II) in obese individuals is known to be upregulated in obesity-induced hypertension, direct evidence that explains the...
Effects of high glucose with or without other metabolic substrates on alpha-adrenergic contractions in rat mesenteric and femoral arteries

Vorn R, Yoo HY

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):91-97.
  • doi: 10.4196/kjpp.2017.21.1.91
Hyperglycemia is associated with an increased risk of cardiovascular diseases. It has been demonstrated that chronic exposure to high glucose impaired endothelial functions. However, specific effects of short-term exposure to...
Intravenous administration of piceatannol, an arginase inhibitor, improves endothelial dysfunction in aged mice

Nguyen MC, Ryoo S

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):83-90.
  • doi: 10.4196/kjpp.2017.21.1.83
Advanced age is one of the risk factors for vascular diseases that are mainly caused by impaired nitric oxide (NO) production. It has been demonstrated that endothelial arginase constrains the...
Acepromazine inhibits hERG potassium ion channels expressed in human embryonic kidney 293 cells

Joo YS, Lee HJ, Choi JS, Sung KW

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):75-82.
  • doi: 10.4196/kjpp.2017.21.1.75
The effects of acepromazine on human ether-à-go-go-related gene (hERG) potassium channels were investigated using whole-cell voltage-clamp technique in human embryonic kidney (HEK293) cells transfected with hERG. The hERG currents were...
Participation of central GABAA receptors in the trigeminal processing of mechanical allodynia in rats

Kim MJ, Park YH, Yang KY, Ju JS, Bae YC, Han SK, Ahn DK

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):65-74.
  • doi: 10.4196/kjpp.2017.21.1.65
Here we investigated the central processing mechanisms of mechanical allodynia and found a direct excitatory link with low-threshold input to nociceptive neurons. Experiments were performed on male Sprague-Dawley rats weighing...
Dehydroevodiamine·HCl enhances cognitive function in memory-impaired rat models

Shin KY, Kim KY, Suh YH

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):55-64.
  • doi: 10.4196/kjpp.2017.21.1.55
Progressive memory impairment such as that associated with depression, stroke, and Alzheimer's disease (AD) can interfere with daily life. In particular, AD, which is a progressive neurodegenerative disorder, prominently features...
Metabolism and excretion of novel pulmonary-targeting docetaxel liposome in rabbits

Wang J, Zhang L, Wang L, Liu Z, Yu Y

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):45-54.
  • doi: 10.4196/kjpp.2017.21.1.45
Our study aims to determine the metabolism and excretion of novel pulmonary-targeting docetaxel liposome (DTX-LP) using the in vitro and in vivo animal experimental models. The metabolism and excretion of...
Regulation of vascular smooth muscle phenotype by cross-regulation of krüppel-like factors

Ha JM, Yun SJ, Jin SY, Lee HS, Kim SJ, Shin HK, Bae SS

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):37-44.
  • doi: 10.4196/kjpp.2017.21.1.37
Regulation of vascular smooth muscle cell (VSMC) phenotype plays an essential role in many cardiovascular diseases. In the present study, we provide evidence that krüppel-like factor 8 (KLF8) is essential...
Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviors via the activation of GABA(A)-ergic systems in rodents

Woo JH, Ha TW, Kang JS, Hong JT, Oh KW

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):27-36.
  • doi: 10.4196/kjpp.2017.21.1.27
Angelicae Gigantis Radix (AGR, Angelica gigas) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin,...
Betulin suppressed interleukin-1β-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat

Ra HJ, Lee HJ, Jo HS, Nam DC, Lee YB, Kang BH, Moon DK, Kim DH, Lee CJ, Hwang SC

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):19-26.
  • doi: 10.4196/kjpp.2017.21.1.19
We investigated whether betulin affects the gene expression, secretion and proteolytic activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3...
Association study between OCTN1 functional haplotypes and Crohn's disease in a Korean population

Jung ES, Park HJ, Kong KA, Choi JH, Cheon JH

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):11-17.
  • doi: 10.4196/kjpp.2016.21.1.11
Crohn's disease (CD) is a chronic inflammatory bowel disease with multifactorial causes including environmental and genetic factors. Several studies have demonstrated that the organic cation/carnitine transporter 1 (OCTN1) non-synonymous variant...
Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats

Yu C, Xiong Y, Chen D, Li Y, Xu B, Lin Y, Tang Z, Jiang C, Wang L

  • Korean J Physiol Pharmacol.
  • 2017 Jan;21(1):1-9.
  • doi: 10.4196/kjpp.2017.21.1.1
Intestinal disorders often co-occur with inflammation and dysmotility. However, drugs which simultaneously improve intestinal inflammation and co-occurring dysmotility are rarely reported. Atractylodin, a widely used herbal medicine, is used to...

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