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Increasing injection frequency enhances the survival of injected bone marrow derived mesenchymal stem cells in a critical limb ischemia animal model

Kang WC, Oh PC, Lee K, Ahn T, Byun K

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):657-667.
  • doi: 10.4196/kjpp.2016.20.6.657
Critical limb ischemia (CLI) is one of the most severe forms of peripheral artery diseases, but current treatment strategies do not guarantee complete recovery of vascular blood flow or reduce...
TonEBP suppresses adipocyte differentiation via modulation of early signaling in 3T3-L1 cells

Kim SJ, Kim T, Choi HN, Cho EJ, Park JB, Jeon BH, Lee SD

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):649-655.
  • doi: 10.4196/kjpp.2016.20.6.649
TonEBP belongs to the Rel family of transcription factors and plays important roles in inflammation as well as kidney homeostasis. Recent studies suggest that TonEBP expression is also involved in...
Hypoxic pulmonary vasoconstriction and vascular contractility in monocrotaline-induced pulmonary arterial hypertensive rats

Kim HJ, Yoo HY

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):641-647.
  • doi: 10.4196/kjpp.2016.20.6.641
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by vascular remodeling of pulmonary arteries (PAs) and increased vascular resistance in the lung. Monocrotaline (MCT), a toxic alkaloid, is widely...
Gintonin facilitates catecholamine secretion from the perfused adrenal medulla

Na SY, Kim KH, Choi MS, Ha KS, Lim DY

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):629-639.
  • doi: 10.4196/kjpp.2016.20.6.629
The present study was designed to investigate the characteristics of gintonin, one of components isolated from Korean Ginseng on secretion of catecholamines (CA) from the isolated perfused model of rat...
Lactobacillus casei strain C1 attenuates vascular changes in spontaneously hypertensive rats

Yap WB, Ahmad FM, Lim YC, Zainalabidin S

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):621-628.
  • doi: 10.4196/kjpp.2016.20.6.621
Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of...
Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3β signaling in rats

Wang CY, Li XD, Hao ZH, Xu D

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):613-619.
  • doi: 10.4196/kjpp.2016.20.6.613
Diabetic cardiomyopathy (DCM), a serious complication of diabetes mellitus, is associated with changes in myocardial structure and function. This study sought to explore the ability of insulin-like growth factor-1 (IGF-1)...
Facilitation of serotonin-induced contraction of rat mesenteric artery by ketamine

Park SW, Noh HJ, Kim JM, Kim B, Cho SI, Kim YS, Woo NS, Kim SH, Bae YM

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):605-611.
  • doi: 10.4196/kjpp.2016.20.6.605
Ketamine is an anesthetic with hypertensive effects, which make it useful for patients at risk of shock. However, previous ex vivo studies reported vasodilatory actions of ketamine in isolated arteries....
The p90rsk-mediated signaling of ethanol-induced cell proliferation in HepG2 cell line

Kim HS, Kim SJ, Bae J, Wang Y, Park SY, Min YS, Je HD, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):595-603.
  • doi: 10.4196/kjpp.2016.20.6.595
Ribosomal S6 kinase is a family of serine/threonine protein kinases involved in the regulation of cell viability. There are two subfamilies of ribosomal s6 kinase, (p90rsk, p70rsk). Especially, p90rsk is...
Evaluation of fish oil-rich in MUFAs for anti-diabetic and anti-inflammation potential in experimental type 2 diabetic rats

Keapai W, Apichai S, Amornlerdpison D, Lailerd N

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):581-593.
  • doi: 10.4196/kjpp.2016.20.6.581
The advantages of monounsaturated fatty acids (MUFAs) on insulin resistance and type 2 diabetes mellitus (T2DM) have been well established. However, the molecular mechanisms of the anti-diabetic action of MUFAs...
Novel functional roles of caspase-related genes in the regulation of apoptosis and autophagy

Shin JH, Min SH

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):573-580.
  • doi: 10.4196/kjpp.2016.20.6.573
Caspases, a family of cysteine proteases, cleave substrates and play significant roles in apoptosis, autophagy, and development. Recently, our group identified 72 genes that interact with Death Caspase-1 (DCP-1) proteins...
The effects of paeoniflorin injection on soluble triggering receptor expressed on myeloid-1 (sTREM-1) levels in severe septic rats

Liu XR, Xu J, Wang YM, Ji MS, Liu FS

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):565-571.
  • doi: 10.4196/kjpp.2016.20.6.565
Paeoniflorin (PAE) is the most abundant compound in Xuebijing injection widely used to treat sepsis. We aimed to investigate effect of PAE on expression of soluble triggering receptor expressed on...
Metabotropic glutamate receptor dependent long-term depression in the cortex

Kang SJ, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2016 Nov;20(6):557-564.
  • doi: 10.4196/kjpp.2016.20.6.557
Metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), a type of synaptic plasticity, is characterized by a reduction in the synaptic response, mainly at the excitatory synapses of the neurons. The...

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