- Blockade of Kv1.5 channels by the antidepressant drug sertraline
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Lee HM, Hahn SJ, Choi BH
- KMID: 2388676
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):193-200.
- doi: 10.4196/kjpp.2016.20.2.193
Sertraline, a selective serotonin reuptake inhibitor (SSRI), has been reported to lead to cardiac toxicity even at therapeutic doses including sudden cardiac death and ventricular arrhythmia. And in a SSRI-independent... -
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- Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein
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Sultan MT, Li HM, Lee YZ, Lim SS, Song DK
- KMID: 2388674
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):177-183.
- doi: 10.4196/kjpp.2016.20.2.177
We fortuitously observed a human neutrophil intracellular free-calcium concentration ([Ca2+]i) increasing activity in the commercially available phosphodiesterase I (PDE I), which is actually dried crude venom of Crotalus atrox. As... -
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- Effects of prunetin on the proteolytic activity, secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo
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Nam DC, Kim BK, Lee HJ, Shin HD, Lee CJ, Hwang SC
- KMID: 2388679
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):221-228.
- doi: 10.4196/kjpp.2016.20.2.221
We investigated whether prunetin affects the proteolytic activity, secretion, and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3... -
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- Myosin VI contributes to malignant proliferation of human glioma cells
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Xu R, Fang XH, Zhong P
- KMID: 2388669
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):139-145.
- doi: 10.4196/kjpp.2016.20.2.139
Previously characterized as a backward motor, myosin VI (MYO6), which belongs to myosin family, moves toward the minus end of the actin track, a direction opposite to all other known... -
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- Mitochondrial calcium uniporter inhibition attenuates mouse bone marrow-derived mast cell degranulation induced by beta-1,3-glucan
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Cuong DV, Kim HK, Marquez J, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2388678
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):213-220.
- doi: 10.4196/kjpp.2016.20.2.213
Mast cells are primary mediators of allergic inflammation. Beta-1,3-glucan (BG) protects against infection and shock by activating immune cells. Activation of the BG receptor induces an increase in intracellular Ca2+,... -
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- The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia
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Lee KE, Cho KO, Choi YS, Kim SY
- KMID: 2388675
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):185-192.
- doi: 10.4196/kjpp.2016.20.2.185
Ampicillin, a beta-lactam antibiotic, dose-dependently protects neurons against ischemic brain injury. The present study was performed to investigate the neuroprotective mechanism of ampicillin in a mouse model of transient global... -
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- NecroX-5 protects mitochondrial oxidative phosphorylation capacity and preserves PGC1alpha expression levels during hypoxia/reoxygenation injury
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Thu VT, Kim HK, Long LT, Nyamaa B, Song IS, Thuy TT, Huy NQ, Marquez J, Kim SH, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2388677
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):201-211.
- doi: 10.4196/kjpp.2016.20.2.201
Although the antioxidant and cardioprotective effects of NecroX-5 on various in vitro and in vivo models have been demonstrated, the action of this compound on the mitochondrial oxidative phosphorylation system... -
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- CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells
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Liu X, Chong Y, Liu H, Han Y, Niu M
- KMID: 2388672
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):161-168.
- doi: 10.4196/kjpp.2016.20.2.161
Abnormal localization of tumor suppressor proteins is a common feature of renal cancer. Nuclear export of these tumor suppressor proteins is mediated by chromosome region maintenance-1 (CRM1). Here, we investigated... -
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- Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-alpha related mechanism
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Tian S, Guo R, Wei S, Kong Y, Wei X, Wang W, Shi X, Jiang H
- KMID: 2388670
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):147-152.
- doi: 10.4196/kjpp.2016.20.2.147
Present study aimed to investigate the eff ect of curcumin-pretreatment on intestinal I/R injury and on intestinal mucosa barrier. Thirty Wistar rats were randomly divided into: sham, I/R, and curcumin... -
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- High glucose and palmitate increases bone morphogenic protein 4 expression in human endothelial cells
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Hong OK, Yoo SJ, Son JW, Kim MK, Baek KH, Song KH, Cha BY, Jo H, Kwon HS
- KMID: 2388673
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):169-175.
- doi: 10.4196/kjpp.2016.20.2.169
Here, we investigated whether hyperglycemia and/or free fatty acids (palmitate, PAL) aff ect the expression level of bone morphogenic protein 4 (BMP4), a proatherogenic marker, in endothelial cells and the... -
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- Anti-diabetic activities of catalpol in db/db mice
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Bao Q, Shen X, Qian L, Gong C, Nie M, Dong Y
- KMID: 2388671
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):153-160.
- doi: 10.4196/kjpp.2016.20.2.153
The objective was to investigate the hypoglycemic action of catalpol in spontaneous diabetes db/db mice. 40 db/db mice were randomly divided into fi ve groups: model control gourp; db/db plus... -
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