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Effects of prunetin on the proteolytic activity, secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo

Nam DC, Kim BK, Lee HJ, Shin HD, Lee CJ, Hwang SC

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):221-228.
  • doi: 10.4196/kjpp.2016.20.2.221
We investigated whether prunetin affects the proteolytic activity, secretion, and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3...
Mitochondrial calcium uniporter inhibition attenuates mouse bone marrow-derived mast cell degranulation induced by beta-1,3-glucan

Cuong DV, Kim HK, Marquez J, Kim N, Ko KS, Rhee BD, Han J

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):213-220.
  • doi: 10.4196/kjpp.2016.20.2.213
Mast cells are primary mediators of allergic inflammation. Beta-1,3-glucan (BG) protects against infection and shock by activating immune cells. Activation of the BG receptor induces an increase in intracellular Ca2+,...
NecroX-5 protects mitochondrial oxidative phosphorylation capacity and preserves PGC1alpha expression levels during hypoxia/reoxygenation injury

Thu VT, Kim HK, Long LT, Nyamaa B, Song IS, Thuy TT, Huy NQ, Marquez J, Kim SH, Kim N, Ko KS, Rhee BD, Han J

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):201-211.
  • doi: 10.4196/kjpp.2016.20.2.201
Although the antioxidant and cardioprotective effects of NecroX-5 on various in vitro and in vivo models have been demonstrated, the action of this compound on the mitochondrial oxidative phosphorylation system...
Blockade of Kv1.5 channels by the antidepressant drug sertraline

Lee HM, Hahn SJ, Choi BH

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):193-200.
  • doi: 10.4196/kjpp.2016.20.2.193
Sertraline, a selective serotonin reuptake inhibitor (SSRI), has been reported to lead to cardiac toxicity even at therapeutic doses including sudden cardiac death and ventricular arrhythmia. And in a SSRI-independent...
The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia

Lee KE, Cho KO, Choi YS, Kim SY

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):185-192.
  • doi: 10.4196/kjpp.2016.20.2.185
Ampicillin, a beta-lactam antibiotic, dose-dependently protects neurons against ischemic brain injury. The present study was performed to investigate the neuroprotective mechanism of ampicillin in a mouse model of transient global...
Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein

Sultan MT, Li HM, Lee YZ, Lim SS, Song DK

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):177-183.
  • doi: 10.4196/kjpp.2016.20.2.177
We fortuitously observed a human neutrophil intracellular free-calcium concentration ([Ca2+]i) increasing activity in the commercially available phosphodiesterase I (PDE I), which is actually dried crude venom of Crotalus atrox. As...
High glucose and palmitate increases bone morphogenic protein 4 expression in human endothelial cells

Hong OK, Yoo SJ, Son JW, Kim MK, Baek KH, Song KH, Cha BY, Jo H, Kwon HS

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):169-175.
  • doi: 10.4196/kjpp.2016.20.2.169
Here, we investigated whether hyperglycemia and/or free fatty acids (palmitate, PAL) aff ect the expression level of bone morphogenic protein 4 (BMP4), a proatherogenic marker, in endothelial cells and the...
CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells

Liu X, Chong Y, Liu H, Han Y, Niu M

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):161-168.
  • doi: 10.4196/kjpp.2016.20.2.161
Abnormal localization of tumor suppressor proteins is a common feature of renal cancer. Nuclear export of these tumor suppressor proteins is mediated by chromosome region maintenance-1 (CRM1). Here, we investigated...
Anti-diabetic activities of catalpol in db/db mice

Bao Q, Shen X, Qian L, Gong C, Nie M, Dong Y

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):153-160.
  • doi: 10.4196/kjpp.2016.20.2.153
The objective was to investigate the hypoglycemic action of catalpol in spontaneous diabetes db/db mice. 40 db/db mice were randomly divided into fi ve groups: model control gourp; db/db plus...
Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-alpha related mechanism

Tian S, Guo R, Wei S, Kong Y, Wei X, Wang W, Shi X, Jiang H

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):147-152.
  • doi: 10.4196/kjpp.2016.20.2.147
Present study aimed to investigate the eff ect of curcumin-pretreatment on intestinal I/R injury and on intestinal mucosa barrier. Thirty Wistar rats were randomly divided into: sham, I/R, and curcumin...
Myosin VI contributes to malignant proliferation of human glioma cells

Xu R, Fang XH, Zhong P

  • Korean J Physiol Pharmacol.
  • 2016 Mar;20(2):139-145.
  • doi: 10.4196/kjpp.2016.20.2.139
Previously characterized as a backward motor, myosin VI (MYO6), which belongs to myosin family, moves toward the minus end of the actin track, a direction opposite to all other known...

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