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16 results

The effects of intra-articular resiniferatoxin on monosodium iodoacetate-induced osteoarthritic pain in rats

Kim Y, Kim EH, Lee KS, Lee K, Park SH, Na SH, Ko C, Kim J, Yooon YW

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):129-136.
  • doi: 10.4196/kjpp.2016.20.1.129
This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a...
Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization

Lee HA, Hyun SA, Park SG, Kim KS, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):119-127.
  • doi: 10.4196/kjpp.2016.20.1.119
Dihydropyridine (DHP) calcium channel blockers (CCBs) have been widely used to treat of several cardiovascular diseases. An excessive shortening of action potential duration (APD) due to the reduction of Ca2+...
Inducibility of human atrial fibrillation in an in silico model reflecting local acetylcholine distribution and concentration

Hwang M, Lee HS, Pak HN, Shim EB

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):111-117.
  • doi: 10.4196/kjpp.2016.20.1.111
Vagal nerve activity has been known to play a crucial role in the induction and maintenance of atrial fibrillation (AF). However, it is unclear how the distribution and concentration of...
Brief low [Mg2+]o-induced Ca2+ spikes inhibit subsequent prolonged exposure-induced excitotoxicity in cultured rat hippocampal neurons

Kim HJ, Yang JS, Yoon SH

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):101-109.
  • doi: 10.4196/kjpp.2016.20.1.101
Reducing [Mg2+]o to 0.1 mM can evoke repetitive [Ca2+]i spikes and seizure activity, which induces neuronal cell death in a process called excitotoxicity. We examined the issue of whether cultured...
(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone displays suppression of inflammatory responses via inhibition of Src, Syk, and NF-kappaB

Kim Y, Jeong EJ, Han Lee IS, Kim MY, Cho JY

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):91-99.
  • doi: 10.4196/kjpp.2016.20.1.91
(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone (MPP) is an aldol condensation product resulting from pyrrole-2-carbaldehyde and m- and p- substituted acetophenones. However, its biological activity has not yet been evaluated. Since it has been reported...
Effect of D-glucose feeding on mortality induced by sepsis

Kim SS, Sim YB, Park SH, Lee JR, Sharma N, Suh HW

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):83-89.
  • doi: 10.4196/kjpp.2016.20.1.83
Sepsis is the life-threatening response to infection which can lead to tissue damage, organ failure, and death. In the current study, the effect of orally administered D-glucose on the mortality...
Blockade of Kv1.5 by paroxetine, an antidepressant drug

Lee HM, Hahn SJ, Choi BH

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):75-82.
  • doi: 10.4196/kjpp.2016.20.1.75
Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has been reported to have an effect on several ion channels including human ether-a-go-go-related gene in a SSRI-independent manner. These results suggest that...
Cardamonin inhibits agonist-induced vascular contractility via Rho-kinase and MEK inhibition

Je HD, Jeong JH

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):69-74.
  • doi: 10.4196/kjpp.2016.20.1.69
The present study was undertaken to investigate the influence of cardamonin on vascular smooth muscle contractility and to determine the mechanism(s) involved. Denuded aortic rings from male rats were used...
Allogeneic clonal mesenchymal stem cell therapy for refractory graft-versus-host disease to standard treatment: a phase I study

Yi HG, Yahng SA, Kim I, Lee JH, Min CK, Kim JH, Kim CS, Song SU

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):63-67.
  • doi: 10.4196/kjpp.2016.20.1.63
Severe graft-versus-host disease (GVHD) is an often lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT). The safety of clinical-grade mesenchymal stem cells (MSCs) has been validated, but mixed results...
Effects of CoCl2 on multi-lineage differentiation of C3H/10T1/2 mesenchymal stem cells

Yoo HI, Moon YH, Kim MS

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):53-62.
  • doi: 10.4196/kjpp.2016.20.1.53
Mesenchymal stem cells (MSCs) in the bone marrow and other somatic tissues reside in an environment with relative low oxygen tension. Cobalt chloride (CoCl2) can mimic hypoxic conditions through transcriptional...
Epigallocatechin-3-gallate rescues LPS-impaired adult hippocampal neurogenesis through suppressing the TLR4-NF-kappaB signaling pathway in mice

Seong KJ, Lee HG, Kook MS, Ko HM, Jung JY, Kim WJ

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):41-51.
  • doi: 10.4196/kjpp.2016.20.1.41
Adult hippocampal dentate granule neurons are generated from neural stem cells (NSCs) in the mammalian brain, and the fate specification of adult NSCs is precisely controlled by the local niches...
Toxicokinetics of paraquat in Korean patients with acute poisoning

Kim HJ, Kim HK, Lee H, Bae JS, Kown JT, Gil HW, Hong SY

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):35-39.
  • doi: 10.4196/kjpp.2016.20.1.35
To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit...
Activation of K+ channel by 1-EBIO rescues the head and neck squamous cell carcinoma cells from Ca2+ ionophore-induced cell death

Yin MZ, Park SW, Kang TW, Kim KS, Yoo HY, Lee J, Hah JH, Sung MH, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):25-33.
  • doi: 10.4196/kjpp.2016.20.1.25
Ion channels in carcinoma and their roles in cell proliferation are drawing attention. Intracellular Ca2+ ([Ca2+]i)-dependent signaling affects the fate of cancer cells. Here we investigate the role of Ca(2+)-activated...
Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice

Guo Q, Shen Z, Yu H, Lu G, Yu Y, Liu X, Zheng P

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):15-23.
  • doi: 10.4196/kjpp.2016.20.1.15
Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity...
cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria

Peng LQ, Li P, Zhang QL, Hong L, Liu LP, Cui X, Cui BR

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):9-14.
  • doi: 10.4196/kjpp.2016.20.1.9
Adenosine 3',5'-cyclic monophosphate (cAMP) participates in the regulation of numerous cellular functions, including the Na(+)-K(+)-ATPase (sodium pump). Ouabain, used in the treatment of several heart diseases, is known to increase...
Neural circuit remodeling and structural plasticity in the cortex during chronic pain

Kim W, Kim SK

  • Korean J Physiol Pharmacol.
  • 2016 Jan;20(1):1-8.
  • doi: 10.4196/kjpp.2016.20.1.1
Damage in the periphery or spinal cord induces maladaptive plastic changes along the somatosensory nervous system from the periphery to the cortex, often leading to chronic pain. Although the role...

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