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11 results

The Inhibitory Mechanism of Gentamicin on Electrical Field Stimulation Response in Rat Bladder Smooth Muscle

Min CH, Wang Y, Bae J, Han JH, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):473-478.
  • doi: 10.4196/kjpp.2015.19.5.473
To see the inhibitory mechanism of gentamicin in response to electrical field stimulation (EFS) using the rat bladder smooth muscle, atropine or guanethidine was treated but had no effect. Methylsergide,...
Trichostatin A Modulates Angiotensin II-induced Vasoconstriction and Blood Pressure Via Inhibition of p66shc Activation

Kang G, Lee YR, Joo HK, Park MS, Kim CS, Choi S, Jeon BH

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):467-472.
  • doi: 10.4196/kjpp.2015.19.5.467
Histone deacetylase (HDAC) has been recognized as a potentially useful therapeutic target for cardiovascular disorders. However, the effect of the HDAC inhibitor, trichostatin A (TSA), on vasoreactivity and hypertension remains...
Toll-like Receptor 2 is Dispensable for an Immediate-early Microglial Reaction to Two-photon Laser-induced Cortical Injury In vivo

Yoon H, Jang YH, Kim SJ, Lee SJ, Kim SK

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):461-465.
  • doi: 10.4196/kjpp.2015.19.5.461
Microglia, the resident macrophages in the central nervous system, can rapidly respond to pathological insults. Toll-like receptor 2 (TLR2) is a pattern recognition receptor that plays a fundamental role in...
Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice

Kim KE, Kim H, Heo RW, Shin HJ, Yi CO, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):451-460.
  • doi: 10.4196/kjpp.2015.19.5.451
Sirtuin 1 (SIRT1) is a mammalian NAD+-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflammation and insulin resistance in dietary and...
Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity

Sung NY, Kim MY, Cho JY

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):441-449.
  • doi: 10.4196/kjpp.2015.19.5.441
Flavonoids are plant pigments that have been demonstrated to exert various pharmacological effects including anti-cancer, anti-diabetic, anti-atherosclerotic, anti-bacterial, and anti-inflammatory activities. However, the molecular mechanisms in terms of exact target...
Pituitary Adenylate Cyclase-activating Polypeptide Inhibits Pacemaker Activity of Colonic Interstitial Cells of Cajal

Wu MJ, Kee KH, Na J, Kim SW, Bae Y, Shin DH, Choi S, Jun JY, Jeong HS, Park JS

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):435-440.
  • doi: 10.4196/kjpp.2015.19.5.435
This study aimed to investigate the effect of pituitary adenylate cyclase-activating peptide (PACAP) on the pacemaker activity of interstitial cells of Cajal (ICC) in mouse colon and to identify the...
Functional Connections of the Vestibulo-spino-adrenal Axis in the Control of Blood Pressure Via the Vestibulosympathetic Reflex in Conscious Rats

Lu HJ, Li MH, Li MZ, Park SE, Kim MS, Jin YZ, Park BR

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):427-434.
  • doi: 10.4196/kjpp.2015.19.5.427
Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements. In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in...
Murrayafoline A Induces a G0/G1-Phase Arrest in Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cells

Han JH, Kim Y, Jung SH, Lee JJ, Park HS, Song GY, Cuong NM, Kim YH, Myung CS

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):421-426.
  • doi: 10.4196/kjpp.2015.19.5.421
The increased potential for vascular smooth muscle cell (VSMC) growth is a key abnormality in the development of atherosclerosis and post-angioplasty restenosis. Abnormally high activity of platelet-derived growth factor (PDGF)...
Dexmedetomidine Modulates Histamine-induced Ca2+ Signaling and Pro-inflammatory Cytokine Expression

Yang D, Hong JH

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):413-420.
  • doi: 10.4196/kjpp.2015.19.5.413
Dexmedetomidine is a sedative and analgesic agent that exerts its effects by selectively agonizing alpha2 adrenoceptor. Histamine is a pathophysiological amine that activates G protein-coupled receptors, to induce Ca2+ release...
Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat

Li X, Shen Y, Lu Y, Yang J

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):401-411.
  • doi: 10.4196/kjpp.2015.19.5.401
Aldose reductase (AR) is known to play a crucial role in the mediation of diabetic and cardiovascular complications. Recently, several studies have demonstrated that allergen-induced airway remodeling and ovalbumin-induced asthma...
The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling

Lee SR, Noh SJ, Pronto JR, Jeong YJ, Kim HK, Song IS, Xu Z, Kwon HY, Kang SC, Sohn EH, Ko KS, Rhee BD, Kim N, Han J

  • Korean J Physiol Pharmacol.
  • 2015 Sep;19(5):389-399.
  • doi: 10.4196/kjpp.2015.19.5.389
Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc (Zn2+) is the key form of zinc involved in signal transductions, which are mainly driven...

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