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Multiple Signaling Pathways Contribute to the Thrombin-induced Secretory Phenotype in Vascular Smooth Muscle Cells

Jeong JY, Son Y, Kim BY, Eo SK, Rhim BY, Kim K

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):549-555.
  • doi: 10.4196/kjpp.2015.19.6.549
We attempted to investigate molecular mechanisms underlying phenotypic change of vascular smooth muscle cells (VSMCs) by determining signaling molecules involved in chemokine production. Treatment of human aortic smooth muscle cells...
Combined Skin Moisturization of Liposomal Serine Incorporated in Hydrogels Prepared with Carbopol ETD 2020, Rhesperse RM 100 and Hyaluronic Acid

Kim H, Ro J, Barua S, Hwang DS, Na SJ, Lee HS, Jeong JH, Woo S, Kim H, Hong B, Yun G, Kim JH, Yoon YH, Park MG, Kim J, Sohn UD, Lee J

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):543-547.
  • doi: 10.4196/kjpp.2015.19.6.543
We investigated the combined moisturizing effect of liposomal serine and a cosmeceutical base selected in this study. Serine is a major amino acid consisting of natural moisturizing factors and keratin,...
Electrophysiological and Mechanical Characteristics in Human Ileal Motility: Recordings of Slow Waves Conductions and Contractions, In vitro

Ryoo SB, Oh HK, Moon SH, Choe EK, Yu SA, Park SH, Park KJ

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):533-542.
  • doi: 10.4196/kjpp.2015.19.6.533
Little human tissue data are available for slow waves and migrating motor complexes, which are the main components of small bowel motility. We investigated the electrophysiological and mechanical characteristics of...
Enhancement of GluN2B Subunit-Containing NMDA Receptor Underlies Serotonergic Regulation of Long-Term Potentiation after Critical Period in the Rat Visual Cortex

Joo K, Rhie DJ, Jang HJ

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):523-531.
  • doi: 10.4196/kjpp.2015.19.6.523
Serotonin [5-hydroxytryptamine (5-HT)] regulates synaptic plasticity in the visual cortex. Although the effects of 5-HT on plasticity showed huge diversity depending on the ages of animals and species, it has...
Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity

Kim S, Kim T, Lee HR, Kong YY, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):515-522.
  • doi: 10.4196/kjpp.2015.19.6.515
Notch signaling is a key regulator of neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-2 (Mib2) is an essential positive...
Nitric Oxide-Induced Autophagy in MC3T3-E1 Cells is Associated with Cytoprotection via AMPK Activation

Yang JY, Park MY, Park SY, Yoo HI, Kim MS, Kim JH, Kim WJ, Jung JY

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):507-514.
  • doi: 10.4196/kjpp.2015.19.6.507
Nitric oxide (NO) is important in the regulation of bone remodeling, whereas high concentration of NO promotes cell death of osteoblast. However, it is not clear yet whether NO-induced autophagy...
Pitavastatin Regulates Ang II Induced Proliferation and Migration via IGFBP-5 in VSMC

Ha YM, Nam JO, Kang YJ

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):499-506.
  • doi: 10.4196/kjpp.2015.19.6.499
Angiotensin II (Ang II), a key mediator of hypertensive, causes structural changes in the arteries (vascular remodeling), which involve alterations in cell growth, vascular smooth muscle cell (VSMC) hypertrophy. Ang...
Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative Stress

Zhang B, Wang B, Cao S, Wang Y

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):491-497.
  • doi: 10.4196/kjpp.2015.19.6.491
Traumatic brain injury (TBI) is a major cause of mortality and long-term disability, which can decrease quality of life. In spite of numerous studies suggesting that Epigallocatechin-3-gallate (EGCG) has been...
Effects of Free Anthraquinones Extract from the Rhubarb on Cell Proliferation and Accumulation of Extracellular Matrix in High Glucose Cultured-Mesangial Cells

Wang J, Fang H, Dong B, Wang D, Li Y, Chen X, Chen L, Wei T, Wei Q

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):485-489.
  • doi: 10.4196/kjpp.2015.19.6.485
Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidney, but the efficacy of currently available strategies for the prevention of DN remains unsatisfactory. In this study,...
Role of Nucleotide-binding and Oligomerization Domain 2 Protein (NOD2) in the Development of Atherosclerosis

Kim HJ

  • Korean J Physiol Pharmacol.
  • 2015 Nov;19(6):479-484.
  • doi: 10.4196/kjpp.2015.19.6.479
NOD2 (nucleotide-binding and oligomerization domain 2) was initially reported as a susceptibility gene for Crohn's disease, with several studies focused on elucidating its molecular mechanism in the progression of Crohn's...

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