Skip Navigation
Skip to contents



15 results

Bacterial PAMPs and Allergens Trigger Increase in [Ca2+]i-induced Cytokine Expression in Human PDL Fibroblasts

Son GY, Shin DM, Hong JH

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):291-297.
  • doi: 10.4196/kjpp.2015.19.3.291
An oral environment is constantly exposed to environmental factors and microorganisms. The periodontal ligament (PDL) fibroblasts within this environment are subject to bacterial infection and allergic reaction. However, how these...
Improvement Characteristics of Bio-active Materials Coated Fabric on Rat Muscular Mitochondria

Lee D, Kim YW, Kim JH, Yang M, Bae H, Lim I, Bang H, Go KC, Yang GW, Rho YH, Park HS, Park EH, Ko JH

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):283-289.
  • doi: 10.4196/kjpp.2015.19.3.283
This study surveys the improvement characteristics in old-aged muscular mitochondria by bio-active materials coated fabric (BMCF). To observe the effects, the fabric (10 and 30%) was worn to old-aged rat...
Effect of Glutamate on the Vestibulo-Solitary Projection after Sodium Nitroprusside-Induced Hypotension in Conscious Rats

Li LW, Jin GS, Yang YZ, Ameer AN, Kim MS, Park BR, Jin YZ

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):275-281.
  • doi: 10.4196/kjpp.2015.19.3.275
Orthostatic hypotension is most common in elderly people, and its prevalence increases with age. Attenuation of the vestibulo-sympathetic reflex (VSR) is commonly associated with orthostatic hypotension. In this study, we...
Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice

Park JH, Ha H

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):269-274.
  • doi: 10.4196/kjpp.2015.19.3.269
Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown...
LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-kappaB Pathways

Lee SJ, Seo KW, Kim CD

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):263-268.
  • doi: 10.4196/kjpp.2015.19.3.263
5-Lipoxygenase (5-LO) plays a pivotal role in the progression of atherosclerosis. Therefore, this study investigated the molecular mechanisms involved in 5-LO expression on monocytes induced by LPS. Stimulation of THP-1...
Nicotine in High Concentration Causes Contraction of Isolated Strips of Rabbit Corpus Cavernosum

Nguyen HB, Lee SY, Park SH, Han JH, Lee MY, Myung SC

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):257-262.
  • doi: 10.4196/kjpp.2015.19.3.257
It is well known that cigarette smoke can cause erectile dysfunction by affecting the penile vascular system. However, the exact effects of nicotine on the corpus cavernosum remains poorly understood....
Ca2+ is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line

Park S, Ku SK, Ji HW, Choi JH, Shin DM

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):249-255.
  • doi: 10.4196/kjpp.2015.19.3.249
Wnk kinase maintains cell volume, regulating various transporters such as sodium-chloride cotransporter, potassium-chloride cotransporter, and sodium-potassium-chloride cotransporter 1 (NKCC1) through the phosphorylation of oxidative stress responsive kinase 1 (OSR1) and...
p-Coumaric Acid Attenuates UVB-Induced Release of Stratifin from Keratinocytes and Indirectly Regulates Matrix Metalloproteinase 1 Release from Fibroblasts

Seok JK, Boo YC

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):241-247.
  • doi: 10.4196/kjpp.2015.19.3.241
Ultraviolet (UV) radiation-induced loss of dermal extracellular matrix is associated with skin photoaging. Recent studies demonstrated that keratinocyte-releasable stratifin (SFN) plays a critical role in skin collagen metabolism by inducing...
Androgen Receptor-dependent Expression of Low-density Lipoprotein Receptor-related Protein 6 is Necessary for Prostate Cancer Cell Proliferation

Park E, Kim EK, Kim M, Ha JM, Kim YW, Jin SY, Shin HK, Ha HK, Lee JZ, Bae SS

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):235-240.
  • doi: 10.4196/kjpp.2015.19.3.235
Androgen receptor (AR) signaling is important for prostate cancer (PCa) cell proliferation. Here, we showed that proliferation of hormone-sensitive prostate cancer cells such as LNCaP was significantly enhanced by testosterone...
Nafamostat Mesilate Inhibits TNF-alpha-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production

Kang MW, Song HJ, Kang SK, Kim Y, Jung SB, Jee S, Moon JY, Suh KS, Lee SD, Jeon BH, Kim CS

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):229-234.
  • doi: 10.4196/kjpp.2015.19.3.229
Nafamostat mesilate (NM) is a serine protease inhibitor with anticoagulant and anti-inflammatory effects. NM has been used in Asia for anticoagulation during extracorporeal circulation in patients undergoing continuous renal replacement...
Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways

Cui Y, Park JY, Wu J, Lee JH, Yang YS, Kang MS, Jung SC, Park JM, Yoo ES, Kim SH, Ahn Jo S, Suk K, Eun SY

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):219-228.
  • doi: 10.4196/kjpp.2015.19.3.219
Excessive microglial activation and subsequent neuroinflammation lead to synaptic loss and dysfunction as well as neuronal cell death, which are involved in the pathogenesis and progression of several neurodegenerative diseases....
Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-kappaB Pathway

Kim EJ, Lee MY, Jeon YJ

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):211-218.
  • doi: 10.4196/kjpp.2015.19.3.211
The present study showed that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibited lipopolysaccharide (LPS)-induced morphological changes in the mouse RAW264.7 macrophage cell line. We also showed...
EGCG Blocked Phenylephrin-Induced Hypertrophy in H9C2 Cardiomyocytes, by Activating AMPK-Dependent Pathway

Cai Y, Zhao L, Qin Y, Wu XQ

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):203-210.
  • doi: 10.4196/kjpp.2015.19.3.203
AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism. Previous studies have shown that activation of AMPK results in suppression of cardiac myocyte hypertrophy via inhibition of the...
Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model

Sharma N, Sim YB, Park SH, Lim SM, Kim SS, Jung JS, Hong JS, Suh HW

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):197-202.
  • doi: 10.4196/kjpp.2015.19.3.197
Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice...
Low Intensity Resistance Exercise Training with Blood Flow Restriction: Insight into Cardiovascular Function, and Skeletal Muscle Hypertrophy in Humans

Park SY, Kwak YS, Harveson A, Weavil JC, Seo KE

  • Korean J Physiol Pharmacol.
  • 2015 May;19(3):191-196.
  • doi: 10.4196/kjpp.2015.19.3.191
Attenuated functional exercise capacity in elderly and diseased populations is a common problem, and stems primarily from physical inactivity. Decreased function and exercise capacity can be restored by maintaining muscular...

Go to Top

Copyright © 2020 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: