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Foeniculum vulgare Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-kB Activation

Lee HS, Kang P, Kim KY, Seol GH

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):183-189.
  • doi: 10.4196/kjpp.2015.19.2.183
Foeniculum vulgare Mill. (fennel) is used to flavor food, in cosmetics, as an antioxidant, and to treat microbial, diabetic and common inflammation. No study to date, however, has assessed the...
Low Non-NMDA Receptor Current Density as Possible Protection Mechanism from Neurotoxicity of Circulating Glutamate on Subfornical Organ Neurons in Rats

Chong W, Kim SN, Han SK, Lee SY, Ryu PD

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):177-181.
  • doi: 10.4196/kjpp.2015.19.2.177
The subfornical organ (SFO) is one of circumventricular organs characterized by the lack of a normal blood brain barrier. The SFO neurons are exposed to circulating glutamate (60~100 microM), which...
Effect of Stimulus Waveform of Biphasic Current Pulse on Retinal Ganglion Cell Responses in Retinal Degeneration (rd1) mice

Ahn KN, Ahn JY, Kim JH, Cho K, Koo KI, Senok SS, Goo YS

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):167-175.
  • doi: 10.4196/kjpp.2015.19.2.167
A retinal prosthesis is being developed for the restoration of vision in patients with retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Determining optimal electrical stimulation parameters for the prosthesis...
Analysis of the Baroreceptor and Vestibular Receptor Inputs in the Rostral Ventrolateral Medulla following Hypotension in Conscious Rats

Lan Y, Lu HJ, Jiang X, Li LW, Yang YZ, Jin GS, Park JY, Kim MS, Park BR, Jin YZ

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):159-165.
  • doi: 10.4196/kjpp.2015.19.2.159
Input signals originating from baroreceptors and vestibular receptors are integrated in the rostral ventrolateral medulla (RVLM) to maintain blood pressure during postural movement. The contribution of baroreceptors and vestibular receptors...
The Effect of Polyphenols Isolated from Cynanchi wilfordii Radix with Anti-inflammatory, Antioxidant, and Anti-bacterial Activity

Jeong S, Lee S, Choi WJ, Sohn UD, Kim W

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):151-158.
  • doi: 10.4196/kjpp.2015.19.2.151
Recently, Cynanchi wilfordii Radix has gained wide use in Asian countries as a functional food effective for relieving fatigue, osteoporosis, and constipation, particularly in menopausal disorders. However, its anti-inflammatory and...
Differential Gene Expression in GPR40-Overexpressing Pancreatic beta-cells Treated with Linoleic Acid

Kim IS, Yang SY, Han JH, Jung SH, Park HS, Myung CS

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):141-149.
  • doi: 10.4196/kjpp.2015.19.2.141
"G protein-coupled receptor 40" (GPR40), a receptor for long-chain fatty acids, mediates the stimulation of glucose-induced insulin secretion. We examined the profiles of differential gene expression in GPR40-activated cells treated...
Association of Angiotensin Converting Enzyme I/D and alpha-actinin-3 R577X Genotypes with Growth Factors and Physical Fitness in Korean Children

Kim K, Ahn N, Cheun W, Byun J, Joo Y

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):131-139.
  • doi: 10.4196/kjpp.2015.19.2.131
This study analyzed the differences in aerobic and anaerobic exercise ability and growth-related indicators, depending on the polymorphism of the ACE and the ACTN3 genes, to understand the genetic influence...
Effect of the Combination of CI-988 and Morphine on Neuropathic Pain after Spinal Cord Injury in Rats

Kim J, Kim Y, Hahm SC, Yoon YW

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):125-130.
  • doi: 10.4196/kjpp.2015.19.2.125
Cholecystokinin is known to be involved in the modulation of nociception and to reduce the efficacy of morphine analgesia. This study investigated the effects of intrathecal administration of morphine and...
Effects on G2/M Phase Cell Cycle Distribution and Aneuploidy Formation of Exposure to a 60 Hz Electromagnetic Field in Combination with Ionizing Radiation or Hydrogen Peroxide in L132 Nontumorigenic Human Lung Epithelial Cells

Jin H, Yoon HE, Lee JS, Kim JK, Myung SH, Lee YS

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):119-124.
  • doi: 10.4196/kjpp.2015.19.2.119
The aim of the present study was to assess whether exposure to the combination of an extremely low frequency magnetic field (ELF-MF; 60 Hz, 1 mT or 2 mT) with...
Long Term Effect of High Glucose and Phosphate Levels on the OPG/RANK/RANKL/TRAIL System in the Progression of Vascular Calcification in rat Aortic Smooth Muscle Cells

Kang YH, Jin JS, Son SM

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):111-118.
  • doi: 10.4196/kjpp.2015.19.2.111
Osteoprotegerin (OPG), receptor activator of NF-kappaB ligand (RANKL)/receptor activator of NF-kappaB (RANK) axis, and TNF-related apoptosis-inducing ligand (TRAIL) participate in vascular calcification process including atherosclerosis, but their contributions under high...
NgR1 Expressed in P19 Embryonal Carcinoma Cells Differentiated by Retinoic Acid Can Activate STAT3

Lee SI, Yun J, Baek JY, Jeong YJ, Kim JA, Kang JS, Park SH, Kim SK, Park SK

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):105-109.
  • doi: 10.4196/kjpp.2015.19.2.105
NgR1, a Nogo receptor, is involved in inhibition of neurite outgrowth and axonal regeneration and regulation of synaptic plasticity. P19 embryonal carcinoma cells were induced to differentiate into neuron-like cells...
Prediction of Pharmacokinetics and Penetration of Moxifloxacin in Human with Intra-Abdominal Infection Based on Extrapolated PBPK Model

Zhu L, Yang J, Zhang Y, Wang Y, Zhang J, Zhao Y, Dong W

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):99-104.
  • doi: 10.4196/kjpp.2015.19.2.99
The aim of this study is to develop a physiologically based pharmacokinetic (PBPK) model in intraabdominal infected rats, and extrapolate it to human to predict moxifloxacin pharmacokinetics profiles in various...
Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration

Hu Z, Oh EH, Chung YB, Hong JT, Oh KW

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):89-97.
  • doi: 10.4196/kjpp.2015.19.2.89
The aim of this study was to investigate the involvement of dopaminergic receptors (DR) in behavioral sensitization, as measured by locomotor activity, and the over-expression of cocaine- and amphetamine-regulated transcript...
Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis

Wang T, Li J, Jin Z, Wu F, Li Y, Wang X, Zhou H, Zhou Q

  • Korean J Physiol Pharmacol.
  • 2015 Mar;19(2):83-88.
  • doi: 10.4196/kjpp.2015.19.2.83
CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) have been shown to play a regulatory or suppressive role in the immune response and are possibly relevant to the pathogenesis of autoimmune diseases....

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