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Characteristics of K+ Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week

Ahn JW, Kang SW, Ahn SC

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):383-388.
  • doi: 10.4196/kjpp.2015.19.4.383
K+ outward currents in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), were investigated using a whole cell patch...
A Novel Nicotinamide Adenine Dinucleotide Correction Method for Mitochondrial Ca2+ Measurement with FURA-2-FF in Single Permeabilized Ventricular Myocytes of Rat

Lee JH, Ha JM, Leem CH

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):373-382.
  • doi: 10.4196/kjpp.2015.19.4.373
Fura-2 analogs are ratiometric fluoroprobes that are widely used for the quantitative measurement of [Ca2+]. However, the dye usage is intrinsically limited, as the dyes require ultraviolet (UV) excitation, which...
Immunotoxicological Effects of Aripiprazole: In vivo and In vitro Studies

Baek KS, Ahn S, Lee J, Kim JH, Kim HG, Kim E, Kim JH, Sung NY, Yang S, Kim MS, Hong S, Kim JH, Cho JY

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):365-372.
  • doi: 10.4196/kjpp.2015.19.4.365
Aripiprazole (ARI) is a commonly prescribed medication used to treat schizophrenia and bipolar disorder. To date, there have been no studies regarding the molecular pathological and immunotoxicological profiling of aripiprazole....
Effect of Bevacizumab on Human Tenon's Fibroblasts Cultured from Primary and Recurrent Pterygium

Park YM, Kim CD, Lee JS

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):357-363.
  • doi: 10.4196/kjpp.2015.19.4.357
The purpose of this study was to compare the inhibitory effect of bevacizumab on human Tenon's fibroblasts (HTFs) cultured from primary and recurrent pterygium. Cultured HTFs were exposed to 2.0,...
Antinociceptive Effects of Transcytosed Botulinum Neurotoxin Type A on Trigeminal Nociception in Rats

Kim HJ, Lee GW, Kim MJ, Yang KY, Kim ST, Bae YC, Ahn DK

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):349-355.
  • doi: 10.4196/kjpp.2015.19.4.349
We examined the effects of peripherally or centrally administered botulinum neurotoxin type A (BoNT-A) on orofacial inflammatory pain to evaluate the antinociceptive effect of BoNT-A and its underlying mechanisms. The...
Effect of Taekwondo Training on Physical Fitness and Growth Index According to IGF-1 Gene Polymorphism in Children

Lee B, Kim K

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):341-347.
  • doi: 10.4196/kjpp.2015.19.4.341
This study analyzed the effect of regular Taekwondo training for 16 weeks on physical fitness and growth index depending on different IGF-1 gene polymorphisms. The subjects of the study were...
Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis

Park JH, Park GM, Kim JK

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):335-340.
  • doi: 10.4196/kjpp.2015.19.4.335
Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and...
Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells

Kim MK, Park HJ, Kim SR, Choi YK, Bae SK, Bae MK

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):327-334.
  • doi: 10.4196/kjpp.2015.19.4.327
The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the involvement of HO-1...
Polymorphisms of SLC22A9 (hOAT7) in Korean Females with Osteoporosis

Ahn SK, Suh CK, Cha SH

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):319-325.
  • doi: 10.4196/kjpp.2015.19.4.319
Among solute carrier proteins, the organic anion transporters (OATs) play an important role for the elimination or reabsorption of endogenous and exogenous negatively charged anionic compounds. Among OATs, SLC22A9 (hOAT7)...
Chronic Alcohol Consumption Results in Greater Damage to the Pancreas Than to the Liver in the Rats

Lee SS, Hong OK, Ju A, Kim MJ, Kim BJ, Kim SR, Kim WH, Cho NH, Kang MI, Kang SK, Kim DJ, Yoo SJ

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):309-318.
  • doi: 10.4196/kjpp.2015.19.4.309
Alcohol consumption increases the risk of type 2 diabetes. However, its effects on prediabetes or early diabetes have not been studied. We investigated endoplasmic reticulum (ER) stress in the pancreas...
Effects of Local Pancreatic Renin-Angiotensin System on the Microcirculation of Rat with Severe Acute Pancreatitis

Pan Z, Feng L, Long H, Wang H, Feng J, Chen F

  • Korean J Physiol Pharmacol.
  • 2015 Jul;19(4):299-307.
  • doi: 10.4196/kjpp.2015.19.4.299
Severe acute pancreatitis (SAP) is normally related to multiorgan dysfunction and local complications. Studies have found that local pancreatic renin-angiotensin system (RAS) was significantly upregulated in drug-induced SAP. The present...

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