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Ursolic Acid-Induced Elevation of Serum Irisin Augments Muscle Strength During Resistance Training in Men

Bang HS, Seo DY, Chung YM, Oh KM, Park JJ, Arturo F, Jeong SH, Kim N, Han J

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):441-446.
  • doi: 10.4196/kjpp.2014.18.5.441
Ursolic acid (UA), a type of pentacyclic triterpenoid carboxylic acid purified from natural plants, can promote skeletal muscle development. We measured the effect of resistance training (RT) with/without UA on...
Inhibitory Effects of Ginsenoside-Rb2 on Nicotinic Stimulation-Evoked Catecholamine Secretion

Lim HJ, Lee HY, Lim DY

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):431-439.
  • doi: 10.4196/kjpp.2014.18.5.431
The aim of the present study was to investigate whether ginsenoside-Rb2 (Rb2) can affect the secretion of catecholamines (CA) in the perfused model of the rat adrenal medulla. Rb2 (3~30...
H2 Receptor-Mediated Relaxation of Circular Smooth Muscle in Human Gastric Corpus: the Role of Nitric Oxide (NO)

Lee SE, Kim DH, Kim YC, Han JH, Choi W, Kim CH, Jeong HW, Park SM, Yun SJ, Choi SY, Sung R, Kim YH, Yoo RY, Sun PH, Kim H, Song YJ, Xu WX, Yun HY, Lee SJ

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):425-430.
  • doi: 10.4196/kjpp.2014.18.5.425
This study was designed to examine the effects of histamine on gastric motility and its specific receptor in the circular smooth muscle of the human gastric corpus. Histamine mainly produced...
Cardiac Damage Biomarkers Following a Triathlon in Elite and Non-elite Triathletes

Park CH, Kim KB, Han J, Ji JG, Kwak YS

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):419-423.
  • doi: 10.4196/kjpp.2014.18.5.419
The purpose of the present study was to investigate cardiac damage biomarkers after a triathlon race in elite and non-elite athlete groups. Fifteen healthy men participated in the study. Based...
Aortic Remodelling in Chronic Nicotine-Administered Rat

Zainalabidin S, Budin SB, Ramalingam A, Lim YC

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):411-418.
  • doi: 10.4196/kjpp.2014.18.5.411
Vascular remodelling is an adaptive mechanism, which counteracts pressure changes in blood circulation. Nicotine content in cigarette increases the risk of hypertension. The exact relationship between nicotine and vascular remodelling...
Bis is Induced by Oxidative Stress via Activation of HSF1

Yoo HJ, Im CN, Youn DY, Yun HH, Lee JH

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):403-409.
  • doi: 10.4196/kjpp.2014.18.5.403
The Bis protein is known to be involved in a variety of cellular processes including apoptosis, migration, autophagy as well as protein quality control. Bis expression is induced in response...
Regulatory Effect of 25-hydroxyvitamin D3 on Nitric Oxide Production in Activated Microglia

Hur J, Lee P, Kim MJ, Cho YW

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):397-402.
  • doi: 10.4196/kjpp.2014.18.5.397
Microglia are activated by inflammatory and pathophysiological stimuli in neurodegenerative diseases, and activated microglia induce neuronal damage by releasing cytotoxic factors like nitric oxide (NO). Activated microglia synthesize a significant...
Inhibition of the Interleukin-11-STAT3 Axis Attenuates Hypoxia-Induced Migration and Invasion in MDA-MB-231 Breast Cancer Cells

Lim JH

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):391-396.
  • doi: 10.4196/kjpp.2014.18.5.391
Although interleukin-11 (IL-11) has been reported to be elevated in hypoxic tumors and has been associated with a poor prognosis in various cancers, little is known about its precise role...
The Effects of Eupatilin (Stillen(R)) on Motility of Human Lower Gastrointestinal Tracts

Ryoo SB, Oh HK, Yu SA, Moon SH, Choe EK, Oh TY, Park KJ

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):383-390.
  • doi: 10.4196/kjpp.2014.18.5.383
Gastrointestinal motility consists of phasic slow-wave contractions and the migrating motor complex (MMC). Eupatilin (Stillen(R)) has been widely used to treat gastritis and peptic ulcers, and various cytokines and neuropeptides...
The Relaxant Effect of Propofol on Isolated Rat Intrapulmonary Arteries

Zhang G, Cui J, Chen Y, Ma J

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):377-381.
  • doi: 10.4196/kjpp.2014.18.5.377
Propofol is a widely used anesthetic. Many studies have shown that propofol has direct effects on blood vessels, but the precise mechanism is not fully understood. Secondary intrapulmonary artery rings...
Alterations of Amino Acid Level in Depressed Rat Brain

Yang P, Li X, Ni J, Tian J, Jing F, Qu C, Lin L, Zhang H

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):371-376.
  • doi: 10.4196/kjpp.2014.18.5.371
Amino-acid neurotransmitter system dysfunction plays a major role in the pathophysiology of depression. Several studies have demonstrated the potential of amino acids as a source of neuro-specific biomarkers could be...
Atypical Antidepressant Activity of 3,4-Bis(3,4-Dimethoxyphenyl) Furan-2,5-Dione Isolated from Heart Wood of Cedrus deodara, in Rodents

Kumar N, Dhayabaran D, Nampoothiri M, Nandakumar K, Puratchikody A, Lalani N, Dawood K, Ghosh A

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):365-369.
  • doi: 10.4196/kjpp.2014.18.5.365
Cedrus deodara (Pinaceae) has been used traditionally in Ayurveda for the treatment of central nervous system disorders. 3,4-bis(3,4-dimethoxyphenyl)furan-2,5-dione (BDFD) was isolated from heart wood of Cedrus deodara and was shown...
MicroRNA-1 in Cardiac Diseases and Cancers

Li J, Dong X, Wang Z, Wu J

  • Korean J Physiol Pharmacol.
  • 2014 Oct;18(5):359-363.
  • doi: 10.4196/kjpp.2014.18.5.359
MicroRNAs (miRs) are endogenous approximately22-nt non-coding RNAs that participate in the regulation of gene expression at post-transcriptional level. MiR-1 is one of the muscle-specific miRs, aberrant expression of miR-1 plays...

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