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Phosphorylation of Akt Mediates Anti-Inflammatory Activity of 1-p-Coumaroyl beta-D-Glucoside Against Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells

Vo VA, Lee JW, Kim JY, Park JH, Lee HJ, Kim SS, Kwon YS, Chun W

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):79-86.
  • doi: 10.4196/kjpp.2014.18.1.79
Hydroxycinnamic acids have been reported to possess numerous pharmacological activities such as antioxidant, anti-inflammatory, and anti-tumor properties. However, the biological activity of 1-p-coumaroyl beta-D-glucoside (CG), a glucose ester derivative of...
Bcl-2 Knockdown Accelerates T Cell Receptor-Triggered Activation-Induced Cell Death in Jurkat T Cells

Lee YJ, Won TJ, Hyung KE, Lee MJ, Moon YH, Lee IH, Go BS, Hwang KW

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):73-78.
  • doi: 10.4196/kjpp.2014.18.1.73
Cell death and survival are tightly controlled through the highly coordinated activation/inhibition of diverse signal transduction pathways to insure normal development and physiology. Imbalance between cell death and survival often...
Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity

Xia A, Xue Z, Wang W, Zhang T, Wei T, Sha X, Ding Y, Zhou W

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):67-72.
  • doi: 10.4196/kjpp.2014.18.1.67
To investigate the alteration of c-Jun N-terminal kinase (JNK) activity after myocardial ischemia reperfusion injury (MIRI) and further explore the effect of naloxone postconditioning on MIRI. Forty male Sprague Dawley...
Reversal of Cisplatin Resistance by Epigallocatechin Gallate Is Mediated by Downregulation of Axl and Tyro 3 Expression in Human Lung Cancer Cells

Kim KC, Lee C

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):61-66.
  • doi: 10.4196/kjpp.2014.18.1.61
Lung cancer is still the number one cause of death from cancer worldwide. The clinical effect of platinum-based chemotherapy for non-small cell lung cancer is constrained by the resistance to...
Dehydroevodiamine.HCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats

Kim HJ, Shin KY, Chang KA, Ahn S, Choi HS, Kim HS, Suh YH

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):55-59.
  • doi: 10.4196/kjpp.2014.18.1.55
Dehydroevodiamine.HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and...
Characteristics of Diprophylline-Induced Bidirectional Modulation on Rat Jejunal Contractility

Liu FF, Chen DP, Xiong YJ, Lv BC, Lin Y

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):47-53.
  • doi: 10.4196/kjpp.2014.18.1.47
In this study, we propose that diprophylline exerts bidirectional modulation (BM) on the isolated rat jejunal segment depending on its contractile state. The results supported the hypothesis. Diprophylline (20 microM)...
The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice

Sim YB, Park SH, Kim SS, Kim CH, Kim SJ, Lim SM, Jung JS, Ryu OH, Choi MG, Suh HW

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):41-46.
  • doi: 10.4196/kjpp.2014.18.1.41
The possible roles of spinal histamine receptors in the regulation of the blood glucose level were studied in ICR mice. Mice were intrathecally (i.t.) treated with histamine 1 (H1) receptor...
Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse

Choi WJ, Kim SK, Park HK, Sohn UD, Kim W

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):33-39.
  • doi: 10.4196/kjpp.2014.18.1.33
Shepherd's purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated...
Nitric Oxide-Induced Apoptosis of Human Dental Pulp Cells Is Mediated by the Mitochondria-Dependent Pathway

Park MY, Jeong YJ, Kang GC, Kim MH, Kim SH, Chung HJ, Jung JY, Kim WJ

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):25-32.
  • doi: 10.4196/kjpp.2014.18.1.25
Nitric oxide (NO) is recognized as a mediator and regulator of inflammatory responses. NO is produced by nitric oxide synthase (NOS), and NOS is abundantly expressed in the human dental...
The Pathophysiologic Roles of TRPM7 Channel

Park HS, Hong C, Kim BJ, So I

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):15-23.
  • doi: 10.4196/kjpp.2014.18.1.15
Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation,...
Advanced Glycation End Products and Diabetic Complications

Singh VP, Bali A, Singh N, Jaggi AS

  • Korean J Physiol Pharmacol.
  • 2014 Feb;18(1):1-14.
  • doi: 10.4196/kjpp.2014.18.1.1
During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation...

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