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Effect of Vestibulosympathetic Reflex and Baroreflex on Expression of pERK in the Nucleus Tractus Solitarius following Acute Hypotension in Conscious Rats

Jiang X, Lan Y, Jin YZ, Park JY, Park BG, Ameer AN, Park BR

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):353-358.
  • doi: 10.4196/kjpp.2014.18.4.353
Control of blood pressure is maintained by the interaction between the arterial baroreflex and vestibulosympathetic reflex during postural changes. In this study, the contributions of vestibular receptors and baroreceptors to...
Effects of Watercress Containing Rutin and Rutin Alone on the Proliferation and Osteogenic Differentiation of Human Osteoblast-like MG-63 Cells

Hyun H, Park H, Jeong J, Kim J, Kim H, Oh HI, Hwang HS, Kim HH

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):347-352.
  • doi: 10.4196/kjpp.2014.18.4.347
Most known osteoporosis medicines are effective for bone resorption, and so there is an increasing demand for medicines that stimulate bone formation. Watercress (N. officinale R. Br.) is widely used...
Effects of Lubiprostone on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Colon

Jiao HY, Kim DH, Ki JS, Ryu KH, Choi S, Jun JY

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):341-346.
  • doi: 10.4196/kjpp.2014.18.4.341
Lubiprostone is a chloride (Cl-) channel activator derived from prostaglandin E1 and used for managing constipation. In addition, lubiprostone affects the activity of gastrointestinal smooth muscles. Interstitial cells of Cajal...
Exendin-4 Improves Nonalcoholic Fatty Liver Disease by Regulating Glucose Transporter 4 Expression in ob/ob Mice

Kim S, Jung J, Kim H, Heo RW, Yi CO, Lee JE, Jeon BT, Kim WH, Hahm JR, Roh GS

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):333-339.
  • doi: 10.4196/kjpp.2014.18.4.333
Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of...
Fucoidan Promotes the Reconstruction of Skin Equivalents

Song YS, Li H, Balcos MC, Yun HY, Baek KJ, Kwon NS, Choi HR, Park KC, Kim DS

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):327-331.
  • doi: 10.4196/kjpp.2014.18.4.327
In this study we investigated the effects of fucoidan on the proliferation of fibroblasts and the reconstruction of a skin equivalent (SE). Fucoidan significantly stimulated the proliferation of CCD-25Sk human...
Protective Effects of the Nuclear Factor Kappa B Inhibitor Pyrrolidine Dithiocarbamate on Experimental Testicular Torsion and Detorsion Injury

Kabay S, Ozden H, Guven G, Burukoglu , Ustuner MC, Topal F, Gunes HV, Ustuner D, Ozbayer C

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):321-326.
  • doi: 10.4196/kjpp.2014.18.4.321
Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factor kappa B...
Effect of Vitamin E Supplementation on Intestinal Barrier Function in Rats Exposed to High Altitude Hypoxia Environment

Xu C, Sun R, Qiao X, Xu C, Shang X, Niu W, Chao Y

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):313-320.
  • doi: 10.4196/kjpp.2014.18.4.313
The study was conducted to investigate the role of vitamin E in the high altitude hypoxia-induced damage to the intestinal barrier in rats. Sprague-Dawley rats were divided into control (Control),...
Scopoletin from Cirsium setidens Increases Melanin Synthesis via CREB Phosphorylation in B16F10 Cells

Ahn MJ, Hur SJ, Kim EH, Lee SH, Shin JS, Kim MK, Uchizono J, Whang WK, Kim DS

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):307-311.
  • doi: 10.4196/kjpp.2014.18.4.307
In this study, we isolated scopoletin from Cirsium setidens Nakai (Compositae) and tested its effects on melanogenesis. Scopoletin was not toxic to cells at concentrations less than 50 microM and...
Cyanidin-3-glucoside Inhibits ATP-induced Intracellular Free Ca2+ Concentration, ROS Formation and Mitochondrial Depolarization in PC12 Cells

Perveen S, Yang JS, Ha TJ, Yoon SH

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):297-305.
  • doi: 10.4196/kjpp.2014.18.4.297
Flavonoids have an ability to suppress various ion channels. We determined whether one of flavonoids, cyanidin-3-glucoside, affects adenosine 5'-triphosphate (ATP)-induced calcium signaling using digital imaging methods for intracellular free Ca2+...
Effect of Phorbol 12-Myristate 13-Acetate on the Differentiation of Adipose-Derived Stromal Cells from Different Subcutaneous Adipose Tissue Depots

Song JK, Lee CH, Hwang SM, Joo BS, Lee SY, Jung JS

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):289-296.
  • doi: 10.4196/kjpp.2014.18.4.289
Human adipose-tissue-derived stromal cells (hADSCs) are abundant in adipose tissue and can differentiate into multi-lineage cell types, including adipocytes, osteoblasts, and chondrocytes. In order to define the optimal harvest site...
A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

Randhawa P, Singh K, Singh N, Jaggi AS

  • Korean J Physiol Pharmacol.
  • 2014 Aug;18(4):279-288.
  • doi: 10.4196/kjpp.2014.18.4.279
Ulcerative colitis and Crohn's disease are a set of chronic, idiopathic, immunological and relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory bowel disorder (IBD). Although the etiological...

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