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14 results

Preventive Effect of Polysaccharide of Larimichthys crocea Swim Bladder on Reserpine Induced Gastric Ulcer in ICR Mice

Li GJ, Sun P, Wang R, Zhou YL, Qian Y, Zhao X

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):183-190.
  • doi: 10.4196/kjpp.2014.18.2.183
This project's aim was to determine the reserpine-induced gastric ulcer preventive effect of polysaccharide of Larimichthys crocea swim bladder (PLCSB) in ICR mice. The anti-gastric ulcer effects of polysaccharide of...
Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction

Li L, Jia Z, Xu L, Wu Y, Zheng Q

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):177-182.
  • doi: 10.4196/kjpp.2014.18.2.177
This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction...
Identification and Functional Characterization of Novel Genetic Variations in the OCTN1 Promoter

Park HJ, Choi JH

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):169-175.
  • doi: 10.4196/kjpp.2014.18.2.169
Human organic cation/carnitine transporter 1 (OCTN1) plays an important role in the transport of drugs and endogenous substances. It is known that a missense variant of OCTN1 is significantly associated...
Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood

Choi JK, Moon KM, Jung SY, Kim JY, Choi SH, Kim DY, Kang S, Chu CW, Kwon SM

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):163-168.
  • doi: 10.4196/kjpp.2014.18.2.163
Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damaged blood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determine whether...
Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation

Yu UY, Yoo BC, Ahn JH

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):155-161.
  • doi: 10.4196/kjpp.2014.18.2.155
Overexpression of amyloid precursor protein with the Swedish mutation causes abnormal hyperphosphorylation of the microtubule-associated protein tau. Hyperphosphorylated isoforms of tau are major components of neurofibrillary tangles, which are histopathological...
Ginger and Its Pungent Constituents Non-Competitively Inhibit Serotonin Currents on Visceral Afferent Neurons

Jin Z, Lee G, Kim S, Park CS, Park YS, Jin YH

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):149-153.
  • doi: 10.4196/kjpp.2014.18.2.149
Nausea and emesis are a major side effect and obstacle for chemotherapy in cancer patients. Employ of antiemetic drugs help to suppress chemotherapy-induced emesis in some patients but not all...
The Hepatotoxicity and Testicular Toxicity Induced by Arecoline in Mice and Protective Effects of Vitamins C and E

Zhou J, Sun Q, Yang Z, Zhang J

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):143-148.
  • doi: 10.4196/kjpp.2014.18.2.143
Arecoline is a major alkaloid of areca nuts which are widely chewed by southeast Asian and it manifests various toxic effects in different organs of human and animals. In this...
The Downregulation of Somatic A-Type K+ Channels Requires the Activation of Synaptic NMDA Receptors in Young Hippocampal Neurons of Rats

Kang MS, Yang YS, Kim SH, Park JM, Eun SY, Jung SC

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):135-141.
  • doi: 10.4196/kjpp.2014.18.2.135
The downregulation of A-type K+ channels (IA channels) accompanying enhanced somatic excitability can mediate epileptogenic conditions in mammalian central nervous system. As IA channels are dominantly targeted by dendritic and...
Alteration of Striatal Tetrahydrobiopterin in Iron-Induced Unilateral Model of Parkinson's Disease

Aryal B, Lee JK, Kim HR, Kim HG

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):129-134.
  • doi: 10.4196/kjpp.2014.18.2.129
It has been suggested that transition metal ions such as iron can produce an oxidative injuries to nigrostriatal dopaminergic neurons, like Parkinson's disease (PD) and subsequent compensative increase of tetrahydrobiopterin...
Effects of Acupuncture Stimulation at Different Acupoints on Formalin-Induced Pain in Rats

Chang KH, Bai SJ, Lee H, Lee BH

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):121-127.
  • doi: 10.4196/kjpp.2014.18.2.121
Acupuncture is the process of stimulating skin regions called meridians or acupoints and has been used to treat pain-related symptoms. However, the pain-relieving effects of acupuncture may be different depending...
Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells

Zhang H, An F, Tang L, Qiu R

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):109-120.
  • doi: 10.4196/kjpp.2014.18.2.109
The epothilones are a class of microtubule inhibitors that exhibit a strong antitumor activity. UTD2 is a novel epothilone analog generated by genetic manipulation of the polyketide biosynthetic gene cluster....
Push-in Head Restraining Apparatus for Intracranial Self Stimulation Tasks in Rats

Roh M, Jang IS, Lee MG

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):103-108.
  • doi: 10.4196/kjpp.2014.18.2.103
Head restraining is an experimental technique that firmly secures the animal's head to a fixation apparatus for the precise control and sensing of behaviors. However, procedural and surgical difficulties and...
Korean Red Ginseng Water Extract Restores Impaired Endothelial Function by Inhibiting Arginase Activity in Aged Mice

Choi K, Yoon J, Lim HK, Ryoo S

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):95-101.
  • doi: 10.4196/kjpp.2014.18.2.95
Cardiovascular disease is the prime cause of morbidity and mortality and the population ages that may contribute to increase in the occurrence of cardiovascular disease. Arginase upregulation is associated with...
DA-6034 Induces [Ca2+]i Increase in Epithelial Cells

Yang YM, Park S, Ji H, Kim TI, Kim EK, Kang KK, Shin DM

  • Korean J Physiol Pharmacol.
  • 2014 Apr;18(2):89-94.
  • doi: 10.4196/kjpp.2014.18.2.89
DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal...

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