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Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats

Lee SE, Song HJ, Park SY, Nam Y, Min CH, Lee DY, Jeong JY, Ha HS, Kim HJ, Whang WK, Jeong JH, Kim IK, Kim HR, Min YS, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):469-477.
  • doi: 10.4196/kjpp.2013.17.5.469
This study investigated effect of extract containing quercetin-3-O-beta-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of...
Disappearance of Hypoxic Pulmonary Vasoconstriction and O2-Sensitive Nonselective Cationic Current in Arterial Myocytes of Rats Under Ambient Hypoxia

Yoo HY, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):463-468.
  • doi: 10.4196/kjpp.2013.17.5.463
Acute hypoxia induces contraction of pulmonary artery (PA) to protect ventilation/perfusion mismatch in lungs. As for the cellular mechanism of hypoxic pulmonary vasoconstriction (HPV), hypoxic inhibition of voltage-gated K+ channel...
The Effect of Metformin Treatment on CRBP-I Level and Cancer Development in the Liver of HBx Transgenic Mice

Kim JH, Alam MM, Park DB, Cho M, Lee SH, Jeon YJ, Yu DY, Kim TD, Kim HY, Cho CG, Lee DH

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):455-461.
  • doi: 10.4196/kjpp.2013.17.5.455
Retinoids regulate not only various cell functions including proliferation and differentiation but also glucose and lipid metabolism. After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the...
Nectandrin A Enhances the BMP-Induced Osteoblastic Differentiation and Mineralization by Activation of p38 MAPK-Smad Signaling Pathway

Kim DY, Kim GW, Chung SH

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):447-453.
  • doi: 10.4196/kjpp.2013.17.5.447
Osteoblastic activity of nectandrin A was examined in C2C12 cells. Nectandrin A enhances the BMP-induced osteoblastic differentiation and mineralization, manifested by the up-regulation of differentiation markers (alkaline phosphatase and osteogenic...
Anti-Depressant Like Effect of Methyl Gallate Isolated from Acer barbinerve in Mice

Lee JK

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):441-446.
  • doi: 10.4196/kjpp.2013.17.5.441
In the present study, the anti-depressant like effect of methyl gallate (MG) isolated from the stem bark of Acer barbinerve was examined in ICR mice. Body weight (BDW) and blood...
Antiapoptotic Effect of Paricalcitol in Gentamicin-induced Kidney Injury

Suh SH, Lee KE, Park JW, Kim IJ, Kim O, Kim CS, Choi JS, Bae EH, Ma SK, Lee JU, Kim SW

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):435-440.
  • doi: 10.4196/kjpp.2013.17.5.435
While the anti-apoptotic effect of paricalcitol has been demonstrated in various animal models, it is not yet clear whether paricalcitol attenuates the apoptosis in gentamicin (GM)-induced kidney injury. We investigated...
Activation of G Proteins by Aluminum Fluoride Enhances RANKL-Mediated Osteoclastogenesis

Park B, Yang YM, Choi BJ, Kim MS, Shin DM

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):427-433.
  • doi: 10.4196/kjpp.2013.17.5.427
Receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis is accompanied by intracellular Ca2+ mobilization in a form of oscillations, which plays essential roles by activating sequentially Ca2+/calmodulin-dependent protein kinase, calcineurin and...
Estrogen Rather Than Progesterone Cause Constipation in Both Female and Male Mice

Oh JE, Kim YW, Park SY, Kim JY

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):423-426.
  • doi: 10.4196/kjpp.2013.17.5.423
Females are more often affected by constipation than males, especially during pregnancy, which is related to the menstrual cycle. Although still controversial, alterations of progesterone and estrogen may be responsible....
Ineffective Doses of Dexmedetomidine Potentiates the Antinociception Induced by Morphine and Fentanyl in Acute Pain Model

Unal M, Gursoy S, Altun A, Duger C, Kol IO, Kaygusuz K, Bagcivan I, Mimaroglu

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):417-422.
  • doi: 10.4196/kjpp.2013.17.5.417
The aim of this study was to evaluate the synergistic potentiation effect of ineffective doses of dexmedetomidine on antinociception induced by morphine and fentanyl in acute pain model in rats....
Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats

Im WJ, Nam Y, Park SY, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):411-415.
  • doi: 10.4196/kjpp.2013.17.5.411
In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each ID50...
Sex Differences in Hippocampal Neuronal Sensitization by Nicotine in M. gerbils

Hur YN, Lee J, Sohn SC, Won CG, Lee HH, Kim DH, Choi SH, Shin KH, Chun BG

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):405-409.
  • doi: 10.4196/kjpp.2013.17.5.405
We studied the sex different nicotine effect on evoked population spike amplitudes (ePSA) and connexin (Cx) expression in the hippocampus CA1 area of gerbils. Acute doses of nicotine bitartrate (0.5...
Chronic Administration of Baicalein Decreases Depression-Like Behavior Induced by Repeated Restraint Stress in Rats

Lee B, Sur B, Park J, Kim SH, Kwon S, Yeom M, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):393-403.
  • doi: 10.4196/kjpp.2013.17.5.393
Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis, has been widely used for the treatment of stress-related neuropsychiatric disorders including depression. Previous studies have demonstrated...
Effects of Vitamin D on Blood Pressure and Endothelial Function

Min B

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):385-392.
  • doi: 10.4196/kjpp.2013.17.5.385
Vitamin D deficiency is prevalent, primarily due to limited sun exposure, which may be observed in urban areas, or as a result of modern lifestyles. Common myths about vitamin D...
Cyclophilin A as a New Therapeutic Target for Hepatitis C Virus-induced Hepatocellular Carcinoma

Lee J

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):375-383.
  • doi: 10.4196/kjpp.2013.17.5.375
Hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections is thought to account for more than 80% of primary liver cancers. Both HBV and...

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