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Influence of Fimasartan (a Novel AT1 Receptor Blocker) on Catecholamine Release in the Adrenal Medulla of Spontaneously Hypertensive Rats

Lim HJ, Lee SK, Lim DY

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):99-109.
  • doi: 10.4196/kjpp.2013.17.1.99
The aim of this study was to determine whether fimasartan, a newly developed AT1 receptor blocker, can affect the CA release in the isolated perfused model of the adrenal medulla...
Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains

Lee KS, Lee JK, Kim HG, Kim HR

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):89-97.
  • doi: 10.4196/kjpp.2013.17.1.89
Developing an animal model for a specific disease is very important in the understanding of the underlying mechanism of the disease and allows testing of newly developed new drugs before...
Anti-Oxidative and Anti-Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells

Lee MJ, Song HJ, Jeong JY, Park SY, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):81-87.
  • doi: 10.4196/kjpp.2013.17.1.81
Quercetin-3-O-beta-D-glucuronopyranoside (QGC) is a flavonoid glucoside extracted from Rumex Aquaticus Herba. In the present study, anti-oxidative and anti-inflammatory effects of QGC were tested in vitro. Epithelial cells obtained from cat...
Anti-Inflammatory and Anti-Superbacterial Activity of Polyphenols Isolated from Black Raspberry

Kim SK, Kim H, Kim SA, Park HK, Kim W

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):73-79.
  • doi: 10.4196/kjpp.2013.17.1.73
The fruit of the black raspberry (Rubus coreanus Miquel) has been employed in traditional medicine, and recent studies have demonstrated its measureable biological activities. However, the root of the black...
TRPM7 Is Essential for RANKL-Induced Osteoclastogenesis

Yang YM, Jung HH, Lee SJ, Choi HJ, Kim MS, Shin DM

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):65-71.
  • doi: 10.4196/kjpp.2013.17.1.65
The transient receptor potential melastatin type 7 (TRPM7) channel is a widely expressed non-selective cation channel with fusion to the C-terminal alpha kinase domain and regarded as a key regulator...
Acute Hypoxia Activates an ENaC-like Channel in Rat Pheochromocytoma (PC12) Cells

Bae YJ, Yoo JC, Park N, Kang D, Han J, Hwang E, Park JY, Hong SG

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):57-64.
  • doi: 10.4196/kjpp.2013.17.1.57
Cells can resist and even recover from stress induced by acute hypoxia, whereas chronic hypoxia often leads to irreversible damage and eventually death. Although little is known about the response(s)...
Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cdelta and epsilon

Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee J, Kim C, Min SS

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):51-56.
  • doi: 10.4196/kjpp.2013.17.1.51
Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by...
Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms

Ahn JH, Kim MH, Kwon HJ, Choi SY, Kwon HY

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):43-50.
  • doi: 10.4196/kjpp.2013.17.1.43
Palmitic acid (PAM), one of the most common saturated fatty acid (SFA) in animals and plants, has been shown to induce apoptosis in exocrine pancreatic AR42J cells. In this study,...
Taxifolin Glycoside Blocks Human ether-a-go-go Related Gene K+ Channels

Yun J, Bae H, Choi SE, Kim JH, Choi YW, Lim I, Lee CS, Lee MW, Ko JH, Seo SJ, Bang H

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):37-42.
  • doi: 10.4196/kjpp.2013.17.1.37
Taxifolin glycoside is a new drug candidate for the treatment of atopic dermatitis (AD). Many drugs cause side effects such as long QT syndrome by blocking the human ether-a-go-go related...
The Inhibitory Effect of Eupatilin on the Agonist-Induced Regulation of Vascular Contractility

Je HD, Kim HD, Jeong JH

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):31-36.
  • doi: 10.4196/kjpp.2013.17.1.31
The present study was undertaken to investigate the influence of eupatilin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used...
Comparison of Ectopic Gene Expression Methods in Rat Neural Stem Cells

Kim W, Kim JH, Kong SY, Park MH, Sohn UD, Kim HJ

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):23-30.
  • doi: 10.4196/kjpp.2013.17.1.23
Neural stem cells (NSCs) have the ability to proliferate and differentiate into various types of cells that compose the nervous system. To study functions of genes in stem cell biology,...
Influence of Aspirin on Pilocarpine-Induced Epilepsy in Mice

Jeong KH, Kim JY, Choi YS, Lee MY, Kim SY

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):15-21.
  • doi: 10.4196/kjpp.2013.17.1.15
Aspirin (acetylsalicylic acid) is one of the most widely used therapeutic agents based on its pharmacological actions, including anti-inflammatory, analgesic, anti-pyretic, and anti-thrombotic effects. In this study, we investigated the...
Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats

Jang SB, Kim D, Kim SY, Park C, Jeong JH, Kuh HJ, Lee J

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):9-13.
  • doi: 10.4196/kjpp.2013.17.1.9
The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion...
Regulation of Ca2+ Signaling in Pulmonary Hypertension

Firth AL, Won JY, Park WS

  • Korean J Physiol Pharmacol.
  • 2013 Feb;17(1):1-8.
  • doi: 10.4196/kjpp.2013.17.1.1
Understanding the cellular and molecular mechanisms involved in the development and progression of pulmonary hypertension (PH) remains imperative if we are to successfully improve the quality of life and life...

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