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12 results

Long-Term Potentiation of Excitatory Synaptic Strength in Spinothalamic Tract Neurons of the Rat Spinal Cord

Hur SW, Park JM

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):553-558.
  • doi: 10.4196/kjpp.2013.17.6.553
Spinal dorsal horn nociceptive neurons have been shown to undergo long-term synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Here, we focused on the spinothalamic tract (STT) neurons...
Binding Specificity of Philyra pisum Lectin to Pathogen-Associated Molecular Patterns, and Its Secondary Structure

Park BT, Kim BS, Park H, Jeong J, Hyun H, Hwang HS, Kim HH

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):547-551.
  • doi: 10.4196/kjpp.2013.17.6.547
We recently reported a Philyra pisum lectin (PPL) that exerts mitogenic effects on human lymphocytes, and its molecular characterization. The present study provides a more detailed characterization of PPL based...
Potassium Currents in Isolated Deiters' Cells of Guinea Pig

Chung JW, Nam EC, Kim WT, Youm JB, Leem CH

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):537-546.
  • doi: 10.4196/kjpp.2013.17.6.537
Deiters' cells are the supporting cells in organ of Corti and are suggested to play an important role in biochemical and mechanical modulation of outer hair cells. We successfully isolated...
Spontaneous Electrical Activity of Cultured Interstitial Cells of Cajal from Mouse Urinary Bladder

Kim SO, Jeong HS, Jang S, Wu MJ, Park JK, Jiao HY, Jun JY, Park JS

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):531-536.
  • doi: 10.4196/kjpp.2013.17.6.531
Interstitial cells of Cajal (ICCs) from the urinary bladder regulate detrusor smooth muscle activities. We cultured ICCs from the urinary bladder of mice and performed patch clamp and intracellular Ca2+...
Functional Characterization of ABCB4 Mutations Found in Low Phospholipid-Associated Cholelithiasis (LPAC)

Kim TH, Park HJ, Choi JH

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):525-530.
  • doi: 10.4196/kjpp.2013.17.6.525
Multidrug resistance 3 (MDR3) is expressed on the canalicular membrane of the hepatocytes and plays an important role in protecting the liver from bile acids. Altered ABCB4 gene expression can...
Cytotoxicity and Structure-activity Relationships of Naphthyridine Derivatives in Human Cervical Cancer, Leukemia, and Prostate Cancer

Hwang YJ, Chung ML, Sohn UD, Im C

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):517-523.
  • doi: 10.4196/kjpp.2013.17.6.517
Naphthyridine compounds are important, because they exhibit various biological activities including anticancer, antimicrobial, and anti-inflammatory activity. Some naphthyridines have antimitotic effects or demonstrate anticancer activity by inhibiting topoisomerase II. These...
The TREK2 Channel Is Involved in the Proliferation of 253J Cell, a Human Bladder Carcinoma Cell

Park KS, Han MH, Jang HK, Kim KA, Cha EJ, Kim WJ, Choi YH, Kim Y

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):511-516.
  • doi: 10.4196/kjpp.2013.17.6.511
Bladder cancer is the seventh most common cancer in men that smoke, and the incidence of disease increases with age. The mechanism of occurrence has not yet been established. Potassium...
Electroacupuncture Analgesia Is Improved by Adenoviral Gene Transfer of Dopamine Beta-hydroxylase into the Hypothalamus of Rats

Kim SJ, Chung ES, Lee JH, Lee CH, Kim SK, Lee HJ, Bae H

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):505-510.
  • doi: 10.4196/kjpp.2013.17.6.505
Electroacupuncture (EA) is a modified form of acupuncture that utilizes electrical stimulation. We previously showed that EA stimulated rats were divided into responders that were sensitive to EA and non-responders...
Effects of Ovarian Cycle on Hemodynamic Responses during Dynamic Exercise in Sedentary Women

Choi HM, Stebbins C, Nho H, Kim MS, Chang MJ, Kim JK

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):499-503.
  • doi: 10.4196/kjpp.2013.17.6.499
This study tested the hypothesis that effects of the menstrual cycle on resting blood pressure carry over to dynamic exercise. Eleven healthy females were studied during the early (EP; low...
Repaglinide, but Not Nateglinide Administered Supraspinally and Spinally Exerts an Anti-Diabetic Action in D-Glucose Fed and Streptozotocin-Treated Mouse Models

Sim YB, Park SH, Kang YJ, Kim SS, Kim CH, Kim SJ, Lim SM, Jung JS, Ryu OH, Choi MG, Suh HW

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):493-497.
  • doi: 10.4196/kjpp.2013.17.6.493
We have recently demonstrated that some anti-diabetic drugs such as biguanide and thizolidinediones administered centrally modulate the blood glucose level, suggesting that orally administered anti-diabetic drugs may modulate the blood...
Effect of Neurosteroid Modulation on Global Ischaemia-Reperfusion-Induced Cerebral Injury in Mice

Grewal AK, Jaggi AS, Rana AC, Singh N

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):485-491.
  • doi: 10.4196/kjpp.2013.17.6.485
The present study was designed to investigate the putative effect of neurosteroid modulation on global ischaemia-reperfusion-induced cerebral injury in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant...
Screening of Genetic Polymorphisms of CYP3A4 and CYP3A5 Genes

Lee JS, Cheong HS, Kim LH, Kim JO, Seo DW, Kim YH, Chung MW, Han SY, Shin HD

  • Korean J Physiol Pharmacol.
  • 2013 Dec;17(6):479-484.
  • doi: 10.4196/kjpp.2013.17.6.479
Given the CYP3A4 and CYP3A5's impact on the efficacy of drugs, the genetic backgrounds of individuals and populations are regarded as an important factor to be considered in the prescription...

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