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15 results

Additive Role of the Vestibular End Organ and Baroreceptors on the Regulation of Blood Pressure in Rats

Lan Y, Yang YZ, Jiang X, Li LW, Jin GS, Kim MS, Park BR, Jin YZ

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):367-373.
  • doi: 10.4196/kjpp.2013.17.4.367
Contribution of the vestibular end organ to regulation of arterial pressure was quantitatively compared with the role of baroreceptors in terms of baroreflex sensitivity and c-Fos protein expression in the...
Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse

Hong SH, Sung R, Kim YC, Suzuki H, Choi W, Park YJ, Ji IW, Kim CH, Myung SC, Lee MY, Kang TM, You RY, Lee KJ, Lim SW, Yun HY, Song YJ, Xu WX, Kim HS, Lee SJ

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):359-365.
  • doi: 10.4196/kjpp.2013.17.4.359
Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K+ channels. Because contractility of uterine...
A Review on Renal Toxicity Profile of Common Abusive Drugs

Singh VP, Singh N, Jaggi AS

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):347-357.
  • doi: 10.4196/kjpp.2013.17.4.347
Drug abuse has become a major social problem of the modern world and majority of these abusive drugs or their metabolites are excreted through the kidneys and, thus, the renal...
Effect of Lutein on L-NAME-Induced Hypertensive Rats

Sung JH, Jo YS, Kim SJ, Ryu JS, Kim MC, Ko HJ, Sim SS

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):339-345.
  • doi: 10.4196/kjpp.2013.17.4.339
We investigated the antihypertensive effect of lutein on NG-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure...
Neuroprotective Effects of AMP-Activated Protein Kinase on Scopolamine Induced Memory Impairment

Kim SJ, Lee JH, Chung HS, Song JH, Ha J, Bae H

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):331-338.
  • doi: 10.4196/kjpp.2013.17.4.331
AMP-activated protein kinase (AMPK), an important regulator of energy metabolism, is activated in response to cellular stress when intracellular levels of AMP increase. We investigated the neuroprotective effects of AMPK...
Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by Desipramine and Citalopram

Choi SH, Chung S, Cho JH, Cho YH, Kim JW, Kim JM, Kim HJ, Kim HJ, Shin KH

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):321-329.
  • doi: 10.4196/kjpp.2013.17.4.321
Rodents exposed to a 15-min pretest swim in the forced swimming test (FST) exhibit prolonged immobility in a subsequent 5-min test swim, and antidepressant treatment before the test swim reduces...
Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells

Youn CK, Park SJ, Li MH, Lee MY, Lee KY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):315-320.
  • doi: 10.4196/kjpp.2013.17.4.315
Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine...
High Glucose Induces Connective Tissue Growth Factor Expression and Extracellular Matrix Accumulation in Rat Aorta Vascular Smooth Muscle Cells Via Extracellular Signal-Regulated Kinase 1/2

Ha YM, Lee DH, Kim M, Kang YJ

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):307-314.
  • doi: 10.4196/kjpp.2013.17.4.307
Connective tissue growth factor (CTGF) is a potent pro-fibrotic factor, which is implicated in fibrosis through extracellular matrix (ECM) induction in diabetic cardiovascular complications. It is an important downstream mediator...
Neuronal Responses in the Globus Pallidus during Subthalamic Nucleus Electrical Stimulation in Normal and Parkinson's Disease Model Rats

Ryu SB, Bae EK, Kim J, Hwang YS, Im C, Chang JW, Shin HC, Kim KH

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):299-306.
  • doi: 10.4196/kjpp.2013.17.4.299
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been widely used as a treatment for the movement disturbances caused by Parkinson's disease (PD). Despite successful application of DBS,...
Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells

Bae YH, Ryu JH, Park HJ, Kim KR, Wee HJ, Lee OH, Jang HO, Bae MK, Kim KW, Bae SK

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):291-297.
  • doi: 10.4196/kjpp.2013.17.4.291
Notch1 has been reported to be highly expressed in triple-negative and other subtypes of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present...
Korean Red Ginseng Induced Cardioprotection against Myocardial Ischemia in Guinea Pig

Lim KH, Kang CW, Choi JY, Kim JH

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):283-289.
  • doi: 10.4196/kjpp.2013.17.4.283
This study was designed to evaluate the protective effect of Korean red ginseng (KRG) against ischemia/reperfusion (I/R) injury in isolated guinea pig heart. KRG has been shown to possess various...
Expression and Activity of the Na-K ATPase in Ischemic Injury of Primary Cultured Astrocytes

Kim MJ, Hur J, Ham IH, Yang HJ, Kim Y, Park S, Cho YW

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):275-281.
  • doi: 10.4196/kjpp.2013.17.4.275
Astrocytes are reported to have critical functions in ischemic brain injury including protective effects against ischemia-induced neuronal dysfunction. Na-K ATPase maintains ionic gradients in astrocytes and is suggested as an...
Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs

Cho YJ, Yi CO, Jeon BT, Jeong YY, Kang GM, Lee JE, Roh GS, Lee JD

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):267-274.
  • doi: 10.4196/kjpp.2013.17.4.267
A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties,...
(-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion

Al-Ajmi N, Al-Maghrebi M, Renno WM

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):259-265.
  • doi: 10.4196/kjpp.2013.17.4.259
The anti-apoptotic effect of (-)-epigallocatechin-3-gallate (EGCG) during unilateral testicular torsion and detorsion (TT/D) was established in our previous study. In mice, the smallest inhibitor of apoptosis, survivin, is alternatively spliced...
Decreasing Effect of Lidocaine.HCl on the Thickness of the Neuronal and Model Membrane

Park SM, Park JS, Kim JH, Baek JH, Yoon TG, Lee DK, Ryu WH, Chung IK, Sohn UD, Jang HO, Yun I

  • Korean J Physiol Pharmacol.
  • 2013 Aug;17(4):253-257.
  • doi: 10.4196/kjpp.2013.17.4.253
This study examined the mechanism of action of a local anesthetic, lidocaine.HCl. Energy transfer between the surface fluorescent probe, 1-anilinonaphthalene-8-sulfonic acid, and the hydrophobic fluorescent probe, 1,3-di(1-pyrenyl) propane, was used...

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