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13 results

Retraction: A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons

Chung G, Kim TH, Shin H, Chae E, Yi H, Moon H, Kim HJ, Kim JS, Jung SJ, Oh SB

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):367-367.
  • doi: 10.4196/kjpp.2012.16.5.367
No abstract available.
Gecko Proteins Exert Anti-Tumor Effect against Cervical Cancer Cells Via PI3-Kinase/Akt Pathway

Jeong AJ, Chung CN, Kim HJ, Bae KS, Choi S, Jun WJ, Shim SI, Kang TH, Leem SH, Chung JW

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):361-365.
  • doi: 10.4196/kjpp.2012.16.5.361
Anti-tumor activity of the proteins from Gecko (GP) on cervical cancer cells, and its signaling mechanisms were assessed by viable cell counting, propidium iodide (PI) staining, and Western blot analysis....
Simultaneous Determination of Glutamate, Glycine, and Alanine in Human Plasma Using Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate and High-Performance Liquid Chromatography

Li QZ, Huang QX, Li SC, Yang MZ, Rao B

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):355-360.
  • doi: 10.4196/kjpp.2012.16.5.355
A simple, sensitive and reproducible high-performance liquid chromatography (HPLC) method has been validated for determining concentrations of glutamate, glycine, and alanine in human plasma. Proteins in plasma were precipitated with...
CTLA-4-Tg/CD-28-KO Mice Exhibit Reduced T Cell Proliferation in vivo Compared to CD-28-KO Mice in a Graft-versus-host Disease Model

Yoo JS, Lee YJ, Yoon JW, Hyung KE, Hwang KW

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):349-353.
  • doi: 10.4196/kjpp.2012.16.5.349
Activated T cells express inhibitory receptors such as CTLA-4 that can downregulate immune responses. Blockade of or genetic deficiency in CTLA-4 can result in autoimmunity. Therefore, strategies to increase the...
Sustained K+ Outward Currents are Sensitive to Intracellular Heteropodatoxin2 in CA1 Neurons of Organotypic Cultured Hippocampi of Rats

Jung SC, Eun SY

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):343-348.
  • doi: 10.4196/kjpp.2012.16.5.343
Blocking or regulating K+ channels is important for investigating neuronal functions in mammalian brains, because voltage-dependent K+ channels (Kv channels) play roles to regulate membrane excitabilities for synaptic and somatic...
Genetic Polymorphisms of Cytochrome P450 2C19 in Functional Dyspeptic Patients Treated with Cimetidine

Kim M, Kong E

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):339-342.
  • doi: 10.4196/kjpp.2012.16.5.339
Inter-individual pharmacokinetic variation of H2-receptor antagonist is related to genetic polymorphism of CYP2C19. We investigated the frequency of CYP2C19 genetic polymorphism and the treatment duration of cimetidine by CYP2C19 genotypes...
cAMP/PKA Agonist Restores the Fasting-Induced Down-Regulation of nNOS Expression in the Paraventricular Nucleus

Yoo SB, Lee S, Lee JY, Kim BT, Lee JH, Jahng JW

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):333-337.
  • doi: 10.4196/kjpp.2012.16.5.333
Gene expression of neuronal nitric oxide synthase (nNOS) changes in the hypothalamic paraventricular nucleus (PVN) depending on feeding conditions, which is decreased during food deprivation and restored by refeeding, and...
Wide Spectrum of Inhibitory Effects of Sertraline on Cardiac Ion Channels

Lee HA, Kim KS, Hyun SA, Park SG, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):327-332.
  • doi: 10.4196/kjpp.2012.16.5.327
Sertraline is a commonly used antidepressant of the selective serotonin reuptake inhibitors (SSRIs) class. In these experiments, we have used the whole cell patch clamp technique to examine the effects...
Antiproliferative and Cytotoxic Effects of Resveratrol in Mitochondria-Mediated Apoptosis in Rat B103 Neuroblastoma Cells

Rahman MA, Kim NH, Kim SH, Oh SM, Huh SO

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):321-326.
  • doi: 10.4196/kjpp.2012.16.5.321
Resveratrol, a natural compound, has been shown to possess anti-cancer, anti-aging, anti-inflammatory, anti-microbial, and neuroprotective activities. In this study, we examined the antiproliferative and cytotoxicity properties of resveratrol in Rat...
The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells

Lim JC, Park SY, Nam Y, Nguyen TT, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):313-320.
  • doi: 10.4196/kjpp.2012.16.5.313
In this study, we focused to identify whether eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone), an extract from Artemisia argyi folium, prevents H2O2-induced injury of cultured feline esophageal epithelial cells. Cell viability was measured by...
Effects of Treadmill Exercise on the Recovery of Dopaminergic Neuron Loss and Muscle Atrophy in the 6-OHDA Lesioned Parkinson's Disease Rat Model

Choe MA, Koo BS, An GJ, Jeon S

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):305-312.
  • doi: 10.4196/kjpp.2012.16.5.305
This study was to determine the effect of exercise on the recovery of dopaminergic neuron loss and muscle atrophy in 6-OHDA-induced hemi Parkinson's disease model. Exercise was loaded twice per...
High K(+)-Induced Relaxation by Nitric Oxide in Human Gastric Fundus

Kim DH, Kim YC, Choi W, Yun HY, Sung R, Kim HS, Kim H, Yoo RY, Park SM, Yun SJ, Song YJ, Xu WX, Lee SJ

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):297-303.
  • doi: 10.4196/kjpp.2012.16.5.297
This study was designed to elucidate high K(+)-induced relaxation in the human gastric fundus. Circular smooth muscle from the human gastric fundus greater curvature showed stretch-dependent high K+ (50 mM)-induced...
Effect of Intensity of Unconditional Stimulus on Reconsolidation of Contextual Fear Memory

Kwak C, Choi JH, Bakes JT, Lee K, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2012 Oct;16(5):293-296.
  • doi: 10.4196/kjpp.2012.16.5.293
Memory reconsolidation is ubiquitous across species and various memory tasks. It is a dynamic process in which memory is modified and/or updated. In experimental conditions, memory reconsolidation is usually characterized...

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