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11 results

Defective Mitochondrial Function and Motility Due to Mitofusin 1 Overexpression in Insulin Secreting Cells

Park KS, Wiederkehr A, Wollheim C

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):71-77.
  • doi: 10.4196/kjpp.2012.16.1.71
Mitochondrial dynamics and distribution is critical for their role in bioenergetics and cell survival. We investigated the consequence of altered fission/fusion on mitochondrial function and motility in INS-1E rat clonal...
Developmental Switch of the Serotonergic Role in the Induction of Synaptic Long-term Potentiation in the Rat Visual Cortex

Park SW, Jang HJ, Cho KH, Kim MJ, Yoon SH, Rhie DJ

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):65-70.
  • doi: 10.4196/kjpp.2012.16.1.65
Synaptic long-term potentiation (LTP) and long-term depression (LTD) have been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of LTP...
Requirement of Pretone by Thromboxane A2 for Hypoxic Pulmonary Vasoconstriction in Precision-cut Lung Slices of Rat

Park SJ, Yoo HY, Kim HJ, Kim JK, Zhang YH, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):59-64.
  • doi: 10.4196/kjpp.2012.16.1.59
Hypoxic pulmonary vasoconstriction (HPV) is physiologically important response for preventing mismatching between ventilation and perfusion in lungs. The HPV of isolated pulmonary arteries (HPV-PA) usually require a partial pretone by...
Acute Toxicity and General Pharmacological Action of QGC EXT

Lee JM, Im WJ, Nam YJ, Oh KH, Lim JC, Whang WK, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):49-57.
  • doi: 10.4196/kjpp.2012.16.1.49
It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute...
Ghrelin Protects Spinal Cord Motoneurons Against Chronic Glutamate Excitotoxicity by Inhibiting Microglial Activation

Lee S, Kim Y, Li E, Park S

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):43-48.
  • doi: 10.4196/kjpp.2012.16.1.43
Glutamate excitotoxicity is emerging as a contributor to degeneration of spinal cord motoneurons in amyotrophic lateral sclerosis (ALS). Recently, we have reported that ghrelin protects motoneurons against chronic glutamate excitotoxicity...
A Novel Pathway Underlying the Inhibitory Effects of Melatonin on Isolated Rat Urinary Bladder Contraction

Han JH, Chang IH, Myung SC, Lee MY, Kim WY, Lee SY, Lee SY, Lee SW, Kim KD

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):37-42.
  • doi: 10.4196/kjpp.2012.16.1.37
The aim of the present study was to elucidate the direct effects of melatonin on bladder activity and to determine the mechanisms responsible for the detrusor activity of melatonin in...
Effects of Inositol 1,4,5-triphosphate on Osteoclast Differentiation in RANKL-induced Osteoclastogenesis

Son A, Kim MS, Jo H, Byun HM, Shin DM

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):31-36.
  • doi: 10.4196/kjpp.2012.16.1.31
The receptor activator of NF-kappaB ligand (RANKL) signal is an activator of tumor necrosis factor receptor-associated factor 6 (TRAF6), which leads to the activation of NF-kappaB and other signal transduction...
Bile Acid Inhibition of N-type Calcium Channel Currents from Sympathetic Ganglion Neurons

Lee HK, Lee KH, Cho ES

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):25-30.
  • doi: 10.4196/kjpp.2012.16.1.25
Under some pathological conditions as bile flow obstruction or liver diseases with the enterohepatic circulation being disrupted, regurgitation of bile acids into the systemic circulation occurs and the plasma level...
The Characteristics of Supramammillary Cells Projecting to the Hippocampus in Stress Response in the Rat

Choi WK, Wirtshafter D, Park HJ, Lee MS, Her S, Shim I

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):17-24.
  • doi: 10.4196/kjpp.2012.16.1.17
The hypothalamus-pituitary-adrenocortex (HPA) axis is the central mediator of the stress response. The supramammillary (SuM) region is relatively unique among the hypothalamic structures in that it sends a large, direct...
Effect of 5-FU and MTX on the Expression of Drug-resistance Related Cancer Stem Cell Markers in Non-small Cell Lung Cancer Cells

Yi H, Cho HJ, Cho SM, Jo K, Park JA, Lee SH, Chang BJ, Kim JS, Shin HC

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):11-16.
  • doi: 10.4196/kjpp.2012.16.1.11
Cancer stem cells (CSCs) are often characterized by the elevated expression of drug-resistance related stem-cell surface markers, such as CD133 and ABCG2. Recently, we reported that CSCs have a high...
Stem Cells in Drug Screening for Neurodegenerative Disease

Kim HJ, Jin CY

  • Korean J Physiol Pharmacol.
  • 2012 Feb;16(1):1-9.
  • doi: 10.4196/kjpp.2012.16.1.1
Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us...

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