- Stem Cells in Drug Screening for Neurodegenerative Disease
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Kim HJ, Jin CY
- KMID: 2285433
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):1-9.
- doi: 10.4196/kjpp.2012.16.1.1
Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us... -
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- Defective Mitochondrial Function and Motility Due to Mitofusin 1 Overexpression in Insulin Secreting Cells
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Park KS, Wiederkehr A, Wollheim C
- KMID: 2285443
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):71-77.
- doi: 10.4196/kjpp.2012.16.1.71
Mitochondrial dynamics and distribution is critical for their role in bioenergetics and cell survival. We investigated the consequence of altered fission/fusion on mitochondrial function and motility in INS-1E rat clonal... -
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- Requirement of Pretone by Thromboxane A2 for Hypoxic Pulmonary Vasoconstriction in Precision-cut Lung Slices of Rat
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Park SJ, Yoo HY, Kim HJ, Kim JK, Zhang YH, Kim SJ
- KMID: 2285441
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):59-64.
- doi: 10.4196/kjpp.2012.16.1.59
Hypoxic pulmonary vasoconstriction (HPV) is physiologically important response for preventing mismatching between ventilation and perfusion in lungs. The HPV of isolated pulmonary arteries (HPV-PA) usually require a partial pretone by... -
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- Ghrelin Protects Spinal Cord Motoneurons Against Chronic Glutamate Excitotoxicity by Inhibiting Microglial Activation
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Lee S, Kim Y, Li E, Park S
- KMID: 2285439
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):43-48.
- doi: 10.4196/kjpp.2012.16.1.43
Glutamate excitotoxicity is emerging as a contributor to degeneration of spinal cord motoneurons in amyotrophic lateral sclerosis (ALS). Recently, we have reported that ghrelin protects motoneurons against chronic glutamate excitotoxicity... -
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- Acute Toxicity and General Pharmacological Action of QGC EXT
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Lee JM, Im WJ, Nam YJ, Oh KH, Lim JC, Whang WK, Sohn UD
- KMID: 2285440
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):49-57.
- doi: 10.4196/kjpp.2012.16.1.49
It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute... -
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- Developmental Switch of the Serotonergic Role in the Induction of Synaptic Long-term Potentiation in the Rat Visual Cortex
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Park SW, Jang HJ, Cho KH, Kim MJ, Yoon SH, Rhie DJ
- KMID: 2285442
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):65-70.
- doi: 10.4196/kjpp.2012.16.1.65
Synaptic long-term potentiation (LTP) and long-term depression (LTD) have been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of LTP... -
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- Bile Acid Inhibition of N-type Calcium Channel Currents from Sympathetic Ganglion Neurons
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Lee HK, Lee KH, Cho ES
- KMID: 2285436
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):25-30.
- doi: 10.4196/kjpp.2012.16.1.25
Under some pathological conditions as bile flow obstruction or liver diseases with the enterohepatic circulation being disrupted, regurgitation of bile acids into the systemic circulation occurs and the plasma level... -
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- Effect of 5-FU and MTX on the Expression of Drug-resistance Related Cancer Stem Cell Markers in Non-small Cell Lung Cancer Cells
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Yi H, Cho HJ, Cho SM, Jo K, Park JA, Lee SH, Chang BJ, Kim JS, Shin HC
- KMID: 2285434
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):11-16.
- doi: 10.4196/kjpp.2012.16.1.11
Cancer stem cells (CSCs) are often characterized by the elevated expression of drug-resistance related stem-cell surface markers, such as CD133 and ABCG2. Recently, we reported that CSCs have a high... -
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- A Novel Pathway Underlying the Inhibitory Effects of Melatonin on Isolated Rat Urinary Bladder Contraction
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Han JH, Chang IH, Myung SC, Lee MY, Kim WY, Lee SY, Lee SY, Lee SW, Kim KD
- KMID: 2285438
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):37-42.
- doi: 10.4196/kjpp.2012.16.1.37
The aim of the present study was to elucidate the direct effects of melatonin on bladder activity and to determine the mechanisms responsible for the detrusor activity of melatonin in... -
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- The Characteristics of Supramammillary Cells Projecting to the Hippocampus in Stress Response in the Rat
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Choi WK, Wirtshafter D, Park HJ, Lee MS, Her S, Shim I
- KMID: 2285435
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):17-24.
- doi: 10.4196/kjpp.2012.16.1.17
The hypothalamus-pituitary-adrenocortex (HPA) axis is the central mediator of the stress response. The supramammillary (SuM) region is relatively unique among the hypothalamic structures in that it sends a large, direct... -
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- Effects of Inositol 1,4,5-triphosphate on Osteoclast Differentiation in RANKL-induced Osteoclastogenesis
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Son A, Kim MS, Jo H, Byun HM, Shin DM
- KMID: 2285437
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):31-36.
- doi: 10.4196/kjpp.2012.16.1.31
The receptor activator of NF-kappaB ligand (RANKL) signal is an activator of tumor necrosis factor receptor-associated factor 6 (TRAF6), which leads to the activation of NF-kappaB and other signal transduction... -
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