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10 results

Dipeptides Inhibit Melanin Synthesis in Mel-Ab Cells through Down-Regulation of Tyrosinase

Lee HE, Kim EH, Choi HR, Sohn UD, Yun HY, Baek KJ, Kwon NS, Park KC, Kim DS

  • Korean J Physiol Pharmacol.
  • 2012 Aug;16(4):287-291.
  • doi: 10.4196/kjpp.2012.16.4.287
This study investigated the effects of proline-serine (PS) and valine-serine (VS) dipeptides on melanogenesis in Mel-Ab cells. Proline-serine and VS significantly inhibited melanin synthesis in a concentration-dependent manner, though neither...
Comparison of Neurite Outgrowth Induced by Erythropoietin (EPO) and Carbamylated Erythropoietin (CEPO) in Hippocampal Neural Progenitor Cells

Oh DH, Lee IY, Choi M, Kim SH, Son H

  • Korean J Physiol Pharmacol.
  • 2012 Aug;16(4):281-285.
  • doi: 10.4196/kjpp.2012.16.4.281
A previous animal study has shown the effects of erythropoietin (EPO) and its non-erythropoietic carbamylated derivative (CEPO) on neurogenesis in the dentate gyrus. In the present study, we sought to...
A Simple Dosing Scheme for Intravenous Busulfan Based on Retrospective Population Pharmacokinetic Analysis in Korean Patients

Choe S, Kim G, Lim HS, Cho SH, Ghim JL, Jung JA, Kim UJ, Noh G, Bae KS, Lee D

  • Korean J Physiol Pharmacol.
  • 2012 Aug;16(4):273-280.
  • doi: 10.4196/kjpp.2012.16.4.273
Busulfan is an antineoplastic agent with a narrow therapeutic window. A post-hoc population pharmacokinetic analysis of a prospective randomized trial for comparison of four-times daily versus once-daily intravenous busulfan was...
Increased HoxB4 Inhibits Apoptotic Cell Death in Pro-B Cells

Park SW, Won KJ, Lee YS, Kim HS, Kim YK, Lee HW, Kim B, Lee BH, Kim JH, Kim DK

  • Korean J Physiol Pharmacol.
  • 2012 Aug;16(4):265-271.
  • doi: 10.4196/kjpp.2012.16.4.265
HoxB4, a homeodomain-containing transcription factor, is involved in the expansion of hematopoietic stem cells and progenitor cells in vivo and in vitro, and plays a key role in regulating the...
The Effect of Methanol on the Structural Parameters of Neuronal Membrane Lipid Bilayers

Joo HJ, Ahn SH, Lee HR, Jung SW, Choi CW, Kim MS, Bae MK, Chung IK, Bae SK, Jang HO, Yun I

  • Korean J Physiol Pharmacol.
  • 2012 Aug;16(4):255-264.
  • doi: 10.4196/kjpp.2012.16.4.255
The structures of the intact synaptosomal plasma membrane vesicles (SPMVs) isolated from bovine cerebral cortexs, and the outer and the inner monolayer separately, were evaluated with 1,6-diphenyl-1,3,5-hexatriene (DPH) and 1,3-di(1-pyrenyl)propane...
The Safety and Pharmacokinetics of Cyanidin-3-Glucoside after 2-Week Administration of Black Bean Seed Coat Extract in Healthy Subjects

Jeon S, Han S, Lee J, Hong T, Yim DS

  • Korean J Physiol Pharmacol.
  • 2012 Aug;16(4):249-253.
  • doi: 10.4196/kjpp.2012.16.4.249
We analyzed the pharmacokinetics of C3G on data from twelve subjects, after 2-week multiple dosing of black bean (Phaseolus vulgaris, Cheongjakong-3-ho) seed coat extract, using the mixed effect analysis method...
Morphologic Evidence of Anti-Tumor Specificity of T Cells Activated by Denritic Cells Derived from Peripheral Blood Mononuclear Cells of Thyroid Cancer Patients

Lee DH

  • Korean J Physiol Pharmacol.
  • 2012 Aug;16(4):243-247.
  • doi: 10.4196/kjpp.2012.16.4.243
Recent studies suggest that immunization with autologous dendritic cells (DCs) results in protective immunity and rejection of established tumors in various human malignancies. The purpose of this study is to...
A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons

Chung G, Kim TH, Shin H, Chae E, Yi H, Moon H, Kim HJ, Kim JS, Jung SJ, Oh SB

  • Korean J Physiol Pharmacol.
  • 2012 Aug;16(4):237-241.
  • doi: 10.4196/kjpp.2012.16.4.237
In this study, we determined mode of action of a novel carbamoyloxy arylalkanoyl arylpiperazine compound (SKL-NP) on hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents (Ih) that plays important roles in neuropathic...
Effects of Single Treatment of Anti-Dementia Drugs on Sleep-Wake Patterns in Rats

Jung JY, Roh M, Ko KK, Jang HS, Lee SR, Ha JH, Jang IS, Lee HW, Lee MG

  • Korean J Physiol Pharmacol.
  • 2012 Aug;16(4):231-236.
  • doi: 10.4196/kjpp.2012.16.4.231
We studied the effects of acetylcholinesterase inhibitors, donepezil and galantamine, and an N-methyl-D-aspartate (NMDA) receptor blocker, memantine, on sleep-wake architecture in rats. Screw electrodes were chronically implanted into the frontal...
Immunostimulatory Effects of beta-glucan Purified from Paenibacillus polymyxa JB115 on Mouse Splenocytes

Kim JM, Joo HG

  • Korean J Physiol Pharmacol.
  • 2012 Aug;16(4):225-230.
  • doi: 10.4196/kjpp.2012.16.4.225
We investigated the effects of beta-glucan purified from Paenibacillus polymyxa JB115 on the viability and proliferation of splenocytes. Splenocytes play a critical role in host immunity. MTT assays and trypan...

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