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10 results

Intracellular Ca2+ Mobilization and Beta-hexosaminidase Release Are Not Influenced by 60 Hz-electromagnetic Fields (EMF) in RBL 2H3 Cells

Hwang YH, Song HS, Kim HR, Ko MS, Jeong JM, Kim YH, Ryu JS, Sohn UD, Gimm YM, Myung SH, Sim SS

  • Korean J Physiol Pharmacol.
  • 2011 Oct;15(5):313-317.
  • doi: 10.4196/kjpp.2011.15.5.313
The effects of extremely low frequency electromagnetic fields (EMF) on intracellular Ca2+ mobilization and cellular function in RBL 2H3 cells were investigated. Exposure to EMF (60 Hz, 0.1 or 1...
Roles of Non-cholinergic Intrapancreatic Nerves, Serotonergic Nerves, on Pancreatic Exocrine Secretion in the Isolated Perfused Rat Pancreas

Jiang ZE, Shin BN, Kim IH, Lee HJ, Yong JH, Lee MJ, Won MH, Lee YL

  • Korean J Physiol Pharmacol.
  • 2011 Oct;15(5):307-312.
  • doi: 10.4196/kjpp.2011.15.5.307
It has been rereported that axons which display 5-hydroxytryptamine (5-HT) immunoreactivity are abundant in the pancreas and the majority of serotonergic axons terminate within intrapancreatic ganglia, islet and acini. This...
Regulator of Calcineurin 1 Isoform 4 (RCAN1.4) Is Overexpressed in the Glomeruli of Diabetic Mice

Jang C, Lim JH, Park CW, Cho YJ

  • Korean J Physiol Pharmacol.
  • 2011 Oct;15(5):299-305.
  • doi: 10.4196/kjpp.2011.15.5.299
Calcineurin (CaN) is activated in diabetes and plays a role in glomerular hypertrophy and extracellular matrix (ECM) accumulation. Here, kidneys from diabetic model mice were investigated for the expression of...
Inhibitory Actions of HERG Currents by the Immunosuppressant Drug Cyclosporin A

Lee SH, Hahn SJ, Min G, Kim J, Jo SH, Choe H, Choi BH

  • Korean J Physiol Pharmacol.
  • 2011 Oct;15(5):291-297.
  • doi: 10.4196/kjpp.2011.15.5.291
The effect of cyclosporin A (CsA), an immunosuppressant, on human ether-a-go-go-related gene (HERG) channel as it is expressed in human embryonic kidney cells was studied using a whole-cell, patch-clamp technique....
Glycine- and GABA-mimetic Actions of Shilajit on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Mice

Yin H, Yang EJ, Park SJ, Han SK

  • Korean J Physiol Pharmacol.
  • 2011 Oct;15(5):285-289.
  • doi: 10.4196/kjpp.2011.15.5.285
Shilajit, a medicine herb commonly used in Ayurveda, has been reported to contain at least 85 minerals in ionic form that act on a variety of chemical, biological, and physical...
Quercetin-induced Growth Inhibition in Human Bladder Cancer Cells Is Associated with an Increase in Ca(2+)-activated K+ Channels

Kim Y, Kim WJ, Cha EJ

  • Korean J Physiol Pharmacol.
  • 2011 Oct;15(5):279-283.
  • doi: 10.4196/kjpp.2011.15.5.279
Quercetin (3,3',4',5,7-pentahydroxyflavone) is an attractive therapeutic flavonoid for cancer treatment because of its beneficial properties including apoptotic, antioxidant, and antiproliferative effects on cancer cells. However, the exact mechanism of action...
Altered Regulation of Renal Nitric Oxide and Atrial Natriuretic Peptide Systems in Lipopolysaccharide-induced Kidney Injury

Bae EH, Kim IJ, Ma SK, Lee JU, Kim SW

  • Korean J Physiol Pharmacol.
  • 2011 Oct;15(5):273-277.
  • doi: 10.4196/kjpp.2011.15.5.273
Nitric oxide (NO) and atrial natriuretic peptide (ANP) may induce vascular relaxation by increasing the production of cyclic guanosine monophosphate (cGMP), an important mediator of vascular tone during sepsis. This...
Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline Ileal Longitudinal Smooth Muscle

Wang Y, Park SY, Oh KH, Min Y, Lee YJ, Lee SY, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2011 Oct;15(5):267-272.
  • doi: 10.4196/kjpp.2011.15.5.267
A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes....
The Protective Effect of Epigallocatechin-3 Gallate on Ischemia/Reperfusion Injury in Isolated Rat Hearts: An ex vivo Approach

Piao CS, Kim DS, Ha KC, Kim HR, Chae HJ, Chae SW

  • Korean J Physiol Pharmacol.
  • 2011 Oct;15(5):259-266.
  • doi: 10.4196/kjpp.2011.15.5.259
The aim of this study was to evaluate the preventive role of epigallocatechin-3 gallate (EGCG, a derivative of green tea) in ischemia/reperfusion (I/R) injury of isolated rat hearts. It has...
Lactosylceramide Mediates the Expression of Adhesion Molecules in TNF-alpha and IFNgamma-stimulated Primary Cultured Astrocytes

Lee JK, Kim JK, Park SH, Sim YB, Jung JS, Suh HW

  • Korean J Physiol Pharmacol.
  • 2011 Oct;15(5):251-258.
  • doi: 10.4196/kjpp.2011.15.5.251
Here we have investigated how lactosylceramide (LacCer) modulates gene expression of adhesion molecules in TNF-alpha and IFNgamma (CM)-stimulated astrocytes. We have observed that stimulation of astrocytes with CM increased the...

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