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9 results

CD40 Co-stimulation Inhibits Sustained BCR-induced Ca2+ Signaling in Response to Long-term Antigenic Stimulation of Immature B Cells

Nguyen YH, Lee KY, Kim TJ, Kim SJ, Kang TM

  • Korean J Physiol Pharmacol.
  • 2011 Jun;15(3):179-187.
  • doi: 10.4196/kjpp.2011.15.3.179
Regulation of B cell receptor (BCR)-induced Ca2+ signaling by CD40 co-stimulation was compared in long-term BCR-stimulated immature (WEHI-231) and mature (Bal-17) B cells. In response to long-term pre-stimulation of immature...
Myoplasmic [Ca2+], Crossbridge Phosphorylation and Latch in Rabbit Bladder Smooth Muscle

Kim YD, Cho MH, Kwon SC

  • Korean J Physiol Pharmacol.
  • 2011 Jun;15(3):171-177.
  • doi: 10.4196/kjpp.2011.15.3.171
Tonic smooth muscle exhibit the latch phenomenon: high force at low myosin regulatory light chains (MRLC) phosphorylation, shortening velocity (Vo), and energy consumption. However, the kinetics of MRLC phosphorylation and...
Direct Corticosteroid Modulation of GABAergic Neurons in the Anterior Hypothalamic Area of GAD65-eGFP Mice

Shin SY, Han TH, Lee SY, Han SK, Park JB, Erdelyi F, Szabo G, Ryu PD

  • Korean J Physiol Pharmacol.
  • 2011 Jun;15(3):163-169.
  • doi: 10.4196/kjpp.2011.15.3.163
Corticosterone is known to modulate GABAergic synaptic transmission in the hypothalamic paraventricular nucleus. However, the underlying receptor mechanisms are largely unknown. In the anterior hypothalamic area (AHA), the sympathoinhibitory center...
Genipin Selectively Inhibits TNF-alpha-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-gamma in Human Endothelial Cells

Hwa JS, Mun L, Kim HJ, Seo HG, Lee JH, Kwak JH, Lee DU, Chang KC

  • Korean J Physiol Pharmacol.
  • 2011 Jun;15(3):157-162.
  • doi: 10.4196/kjpp.2011.15.3.157
Vascular inflammation process has been suggested to be an important risk factor in the development of atherosclerosis. Recently we reported that induction of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) selectively inhibits vascular...
GS28 Protects Neuronal Cell Death Induced by Hydrogen Peroxide under Glutathione-Depleted Condition

Lee HO, Byun YJ, Cho KO, Kim SY, Lee SB, Kim HS, Kwon OJ, Jeong SW

  • Korean J Physiol Pharmacol.
  • 2011 Jun;15(3):149-156.
  • doi: 10.4196/kjpp.2011.15.3.149
Golgi SNAP receptor complex 1 (GS28) has been implicated in vesicular transport between intra-Golgi networks and between endoplasmic reticulum (ER) and Golgi. Additional role(s) of GS28 within cells have not...
The Relaxing Effect of alpha-Defensin 1 on the Adrenergic Responses of Rat Bladder

Lee SY, Kim DK, Kim KD, Myung SC, Lee MY

  • Korean J Physiol Pharmacol.
  • 2011 Jun;15(3):143-147.
  • doi: 10.4196/kjpp.2011.15.3.143
Defensins, cysteine-rich cationic polypeptides released from neutrophils, are known to have powerful antimicrobial properties. In this study, we sacrificed 30 rats to investigate the effects of alpha-defensin 1 on detrusor...
Influence of Exposure to Extremely Low Frequency Magnetic Field on Neuroendocrine Cells and Hormones in Stomach of Rats

Hong ME, Yoon KH, Jung YY, Lee TJ, Park ES, Sohn UD, Jeong JH

  • Korean J Physiol Pharmacol.
  • 2011 Jun;15(3):137-142.
  • doi: 10.4196/kjpp.2011.15.3.137
Extremely low frequency magnetic fields (ELF-MF) have the ability to produce a variety of behavioral and physiological changes in animals. The stomach, as the most sensitive part of the neuroendocrine...
5-Hydroxytryptamine Generates Tonic Inward Currents on Pacemaker Activity of Interstitial Cells of Cajal from Mouse Small Intestine

Shahi PK, Choi S, Zuo DC, Yeum CH, Yoon PJ, Lee J, Kim YD, Park CG, Kim MY, Shin HR, Oh HJ, Jun JY

  • Korean J Physiol Pharmacol.
  • 2011 Jun;15(3):129-135.
  • doi: 10.4196/kjpp.2011.15.3.129
In this study we determined whether or not 5-hydroxytryptamine (5-HT) has an effect on the pacemaker activities of interstitial cells of Cajal (ICC) from the mouse small intestine. The actions...
Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase

Shin W, Cuong TD, Lee JH, Min B, Jeon BH, Lim HK, Ryoo S

  • Korean J Physiol Pharmacol.
  • 2011 Jun;15(3):123-128.
  • doi: 10.4196/kjpp.2011.15.3.123
Caesalpinia sappan (C. sappan) is a medicinal plant used for promoting blood circulation and removing stasis. During a screening procedure on medicinal plants, the ethylacetate extract of the lignum of...

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