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c-Fos Expression in the Nucleus of the Solitary Tract in Response to Salt Stimulation in Rats

Kwak Y, Rhyu MR, Bai SJ, Sa YH, Kwon MJ, Lee BH

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):437-443.
  • doi: 10.4196/kjpp.2011.15.6.437
Salt signals in tongue are relayed to the nucleus of the solitary tract (NST). This signaling is very important to determine whether to swallow salt-related nutrition or not and suggests...
Alteration of Ryanodine-receptors in Cultured Rat Aortic Smooth Muscle Cells

Kim EJ, Kim DK, Kim SH, Lee KM, Park HS, Kim SH

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):431-436.
  • doi: 10.4196/kjpp.2011.15.6.431
Vascular smooth muscle cells can obtain a proliferative function in environments such as atherosclerosis in vivo or primary culture in vitro. Proliferation of vascular smooth muscle cells is accompanied by...
Cytotoxicities and Quantitative Structure Activity Relationships of B13 Sulfonamides in HT-29 and A549 Cells

Lee SK, Park SM, Im C

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):423-429.
  • doi: 10.4196/kjpp.2011.15.6.423
B13 analogues are being considered as therapeutic agents for cancer cells, since B13 is a ceramide analogue and inhibits ceramidase to promote apoptosis in cancer cells. B13 sulfonamides are assumed...
Spontaneous Oscillatory Rhythm in Retinal Activities of Two Retinal Degeneration (rd1 and rd10) Mice

Goo YS, Ahn KN, Song YJ, Ahn SH, Han SK, Ryu SB, Kim KH

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):415-422.
  • doi: 10.4196/kjpp.2011.15.6.415
Previously, we reported that besides retinal ganglion cell (RGC) spike, there is ~ 10 Hz oscillatory rhythmic activity in local field potential (LFP) in retinal degeneration model, rd1 mice. The...
Nitric Oxide-mediated Relaxation by High K+ in Human Gastric Longitudinal Smooth Muscle

Kim YC, Choi W, Yun HY, Sung R, Yoo RY, Park SM, Yun SJ, Kim MJ, Song YJ, Xu WX, Lee SJ

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):405-413.
  • doi: 10.4196/kjpp.2011.15.6.405
This study was designed to elucidate high-K+induced response of circular and longitudinal smooth muscle from human gastric corpus using isometric contraction. Contraction from circular and longitudinal muscle stripes of gastric...
Cigarette Smoke Extract-induced Reduction in Migration and Contraction in Normal Human Bronchial Smooth Muscle Cells

Yoon CH, Park HJ, Cho YW, Kim EJ, Lee JD, Kang KR, Han J, Kang D

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):397-403.
  • doi: 10.4196/kjpp.2011.15.6.397
The proliferation, migration, cytokine release, and contraction of airway smooth muscle cells are key events in the airway remodeling process that occur in lung disease such as asthma, chronic obstruction...
Blockade of ERK Phosphorylation in the Nucleus Accumbens Inhibits the Expression of Cocaine-induced Behavioral Sensitization in Rats

Kim S, Shin JK, Yoon HS, Kim JH

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):389-395.
  • doi: 10.4196/kjpp.2011.15.6.389
Repeated administration of psychostimulants such as cocaine leads to the development of behavioral sensitization. Extracellular signal-Regulated Kinase (ERK), an enzyme important for long-term neuronal plasticity, has been implicated in such...
Role of Regulators of G-Protein Signaling 4 in Ca2+ Signaling in Mouse Pancreatic Acinar Cells

Park S, Lee SI, Shin DM

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):383-388.
  • doi: 10.4196/kjpp.2011.15.6.383
Regulators of G-protein signaling (RGS) proteins are regulators of Ca2+ signaling that accelerate the GTPase activity of the G-protein alpha-subunit. RGS1, RGS2, RGS4, and RGS16 are expressed in the pancreas,...
A Computational Model of the Temperature-dependent Changes in Firing Patterns in Aplysia Neurons

Hyun NG, Hyun KH, Hyun KB, Han JH, Lee K, Kaang BK

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):371-382.
  • doi: 10.4196/kjpp.2011.15.6.371
We performed experiments using Aplysia neurons to identify the mechanism underlying the changes in the firing patterns in response to temperature changes. When the temperature was gradually increased from 11degrees...
Inhibition of Inducible Nitric Oxide Synthase Attenuates Monosodium Urate-induced Inflammation in Mice

Ju TJ, Dan JM, Cho YJ, Park SY

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):363-369.
  • doi: 10.4196/kjpp.2011.15.6.363
The present study elucidated the effect of the selective inducible nitric oxide synthase (iNOS) inhibitor N6-(1-iminoethyl)-L-lysine (L-NIL) on monosodium urate (MSU) crystal-induced inflammation and edema in mice feet. L-NIL (5...
The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation

Bhuiyan MI, Kim HB, Kim SY, Cho KO

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):353-361.
  • doi: 10.4196/kjpp.2011.15.6.353
In this study, cyanidin-3-glucoside (C3G) fraction extracted from the mulberry fruit (Morus alba L.) was investigated for its neuroprotective effects against oxygen-glucose deprivation (OGD) and glutamate-induced cell death in rat...
4-phenylbutyric Acid Regulates Collagen Synthesis and Secretion Induced by High Concentrations of Glucose in Human Gingival Fibroblasts

Lee GH, Oh HW, Lim HD, Lee W, Chae HJ, Kim HR

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):345-351.
  • doi: 10.4196/kjpp.2011.15.6.345
High glucose leads to physio/pathological alterations in diabetes patients. We investigated collagen production in human gingival cells that were cultured in high concentrations of glucose. Collagen synthesis and secretion were...
Vasorelaxing Activity of Ulmus davidiana Ethanol Extracts in Rats: Activation of Endothelial Nitric Oxide Synthase

Cho EJ, Park MS, Kim SS, Kang G, Choi S, Lee YR, Chang SJ, Lee KH, Lee SD, Park JB, Jeon BH

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):339-344.
  • doi: 10.4196/kjpp.2011.15.6.339
Ulmus davidiana var. japonica Rehder (Urticales: Ulmaceae) (UD) is a tree widespread in northeast Asia. It is traditionally used for anticancer and anti-inflammatory therapy. The present study investigated the effect...
The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats

Park HJ, Shim HS, Kim KS, Shim I

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):333-338.
  • doi: 10.4196/kjpp.2011.15.6.333
Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of...
Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats

Asiabanha , Asadikaram G, Rahnema A, Mahmoodi M, Hasanshahi G, Hashemi M, Khaksari M

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):327-332.
  • doi: 10.4196/kjpp.2011.15.6.327
It has been shown that some opium derivatives promote cell death via apoptosis. This study was designed to examine the influence of opium addiction on brain and liver cells apoptosis...
The Protective Effect of Quercetin-3-O-beta-D-Glucuronopyranoside on Ethanol-induced Damage in Cultured Feline Esophageal Epithelial Cells

Cho JH, Park SY, Lee HS, Whang WK, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2011 Dec;15(6):319-326.
  • doi: 10.4196/kjpp.2011.15.6.319
Quercetin-3-O-beta-D-glucuronopyranoside (QGC) is a flavonoid glucoside extracted from Rumex Aquaticus Herba. We aimed to explore its protective effect against ethanol-induced cell damage and the mechanism involved in the effect in...

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