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7 results

Amphetamine-induced ERM Proteins Phosphorylation Is through PKCbeta Activation in PC12 Cells

Jeong HJ, Kim JH, Jeon S

  • Korean J Physiol Pharmacol.
  • 2011 Aug;15(4):245-249.
  • doi: 10.4196/kjpp.2011.15.4.245
Amphetamine, a synthetic psychostimulant, is transported by the dopamine transporter (DAT) to the cytosol and increases the exchange of extracellular amphetamine by intracellular dopamine. Recently, we reported that the phosphorylation...
Molecular Characterization and Mitogenic Activity of a Lectin from Purse Crab Philyra Pisum

Na JC, Park BT, Chung WH, Kim HH

  • Korean J Physiol Pharmacol.
  • 2011 Aug;15(4):241-244.
  • doi: 10.4196/kjpp.2011.15.4.241
A lectin from the hemolymph of purse crab, Philyra pisum, was found to have anti-proliferative activity on human lung cancer cells by our laboratory. In this study, P. pisum lectin...
A Computational Model of Cytosolic and Mitochondrial [Ca2+] in Paced Rat Ventricular Myocytes

Youm JB, Choi SW, Jang CH, Kim HK, Leem CH, Kim N, Han J

  • Korean J Physiol Pharmacol.
  • 2011 Aug;15(4):217-239.
  • doi: 10.4196/kjpp.2011.15.4.217
We carried out a series of experiment demonstrating the role of mitochondria in the cytosolic and mitochondrial Ca2+ transients and compared the results with those from computer simulation. In rat...
Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells

Kim J, Lee JW, Kim SI, Choi YJ, Lee WK, Jeong MJ, Cha SH, Lee HJ, Chun W, Kim SS

  • Korean J Physiol Pharmacol.
  • 2011 Aug;15(4):211-216.
  • doi: 10.4196/kjpp.2011.15.4.211
Glioblastoma multiforme is one of the most common and aggressive tumors in central nervous system. It often possesses characteristic necrotic lesions with hemorrhages, which increase the chances of exposure to...
Cilostazol Inhibits Vascular Smooth Muscle Cell Proliferation and Reactive Oxygen Species Production through Activation of AMP-activated Protein Kinase Induced by Heme Oxygenase-1

Kim JE, Sung JY, Woo CH, Kang YJ, Lee KY, Kim HS, Kwun WH, Choi HC

  • Korean J Physiol Pharmacol.
  • 2011 Aug;15(4):203-210.
  • doi: 10.4196/kjpp.2011.15.4.203
Cilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular cAMP levels and activates protein kinase A, thereby inhibiting vascular smooth muscle cell (VSMC) proliferation. We investigated whether AMP-activated...
Inhibitory Effects of Quercetin on Muscle-type of Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes

Lee BH, Shin TJ, Hwang SH, Choi SH, Kang J, Kim HJ, Park CW, Lee SH, Nah SY

  • Korean J Physiol Pharmacol.
  • 2011 Aug;15(4):195-201.
  • doi: 10.4196/kjpp.2011.15.4.195
The flavonoid quercetin is a low molecular weight compound generally found in apple, gingko, tomato, onion and other red-colored fruits and vegetables. Like other flavonoids, quercetin has diverse pharmacological actions....
Increased Expression of ATP-sensitive K+ Channels Improves the Right Ventricular Tolerance to Hypoxia in Rabbit Hearts

Choi SW, Ahn JS, Kim HK, Kim N, Choi TH, Park SW, Ko EA, Park WS, Song DK, Han J

  • Korean J Physiol Pharmacol.
  • 2011 Aug;15(4):189-194.
  • doi: 10.4196/kjpp.2011.15.4.189
ATP-sensitive K+ channels (KATP) are major component of preventing ischemia-reperfusion injury. However, there is little information regarding to the expressional difference of K(ATP) and its function between left and right...

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