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Matrix Metalloproteinase Inhibitors Attenuate Neuroinflammation Following Focal Cerebral Ischemia in Mice

Park CH, Shin TK, Lee HY, Kim SJ, Lee WS

  • Korean J Physiol Pharmacol.
  • 2011 Apr;15(2):115-122.
  • doi: 10.4196/kjpp.2011.15.2.115
The aim of this study was to investigate whether matrix metalloproteinase (MMP) inhibitors attenuate neuroinflammation in an ischemic brain following photothrombotic cortical ischemia in mice. Male C57BL/6 mice were anesthetized,...
Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau

Kim SI, Lee WK, Kang SS, Lee SY, Jeong MJ, Lee HJ, Kim SS, Johnson GV, Chun W

  • Korean J Physiol Pharmacol.
  • 2011 Apr;15(2):107-114.
  • doi: 10.4196/kjpp.2011.15.2.107
Neurofibrillary tangle (NFT) is a characteristic hallmark of Alzheimer's disease. GSK3beta has been reported to play a major role in the NFT formation of tau. Dysfunction of autophagy might facilitate...
Characterization and Immunopotentiating Effects of the Glycoprotein Isolated from Dioscorea Batatas

Huong PT, Lee CH, Li MH, Lee MY, Kim JK, Lee SM, Seon JH, Lee DC, Jeon YJ

  • Korean J Physiol Pharmacol.
  • 2011 Apr;15(2):101-106.
  • doi: 10.4196/kjpp.2011.15.2.101
We demonstrate that glycoprotein isolated from Dioscorea batatas (GDB) has immunostimulatory effects including macrophage activation. Analysis of infiltration of inflammatory cells into peritoneal cavity showed GDB treatment significantly increased the...
Regulation of DREAM Expression by Group I mGluR

Lee J, Kim I, Oh SR, Ko SJ, Lim MK, Kim DG, Kim CH

  • Korean J Physiol Pharmacol.
  • 2011 Apr;15(2):95-100.
  • doi: 10.4196/kjpp.2011.15.2.95
DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no...
Fucoidan Enhances the Survival and Sustains the Number of Splenic Dendritic Cells in Mouse Endotoxemia

Ko EJ, Joo HG

  • Korean J Physiol Pharmacol.
  • 2011 Apr;15(2):89-94.
  • doi: 10.4196/kjpp.2011.15.2.89
Fucoidan is a sulfated polysaccharide derived from brown algae that has been reported to perform multiple biological activities, including immunostimulation. In this study, we investigated whether fucoidan has beneficial effects...
HO-1 Induced by Cilostazol Protects Against TNF-alpha-associated Cytotoxicity via a PPAR-gamma-dependent Pathway in Human Endothelial Cells

Park SY, Bae JU, Hong KW, Kim CD

  • Korean J Physiol Pharmacol.
  • 2011 Apr;15(2):83-88.
  • doi: 10.4196/kjpp.2011.15.2.83
A large body of evidence has indicated that induction of endogenous antioxidative proteins seems to be a reasonable strategy for delaying the progression of cell injury. In our previous study,...
Modern Methods for Analysis of Antiepileptic Drugs in the Biological Fluids for Pharmacokinetics, Bioequivalence and Therapeutic Drug Monitoring

Kang J, Park YS, Kim SH, Kim SH, Jun MY

  • Korean J Physiol Pharmacol.
  • 2011 Apr;15(2):67-81.
  • doi: 10.4196/kjpp.2011.15.2.67
Epilepsy is a chronic disease occurring in approximately 1.0% of the world's population. About 30% of the epileptic patients treated with availably antiepileptic drugs (AEDs) continue to have seizures and...

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