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Effects of Erythropoietin on Memory Deficits and Brain Oxidative Stress in the Mouse Models of Dementia

Kumar R, Jaggi AS, Singh N

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):345-352.
  • doi: 10.4196/kjpp.2010.14.5.345
The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice. Memory impairment was produced by scopolamine (0.5 mg/kg, i.p.) and intracerebroventricular streptozotocin (i.c.v STZ,...
Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex

Jang HJ, Cho KH, Park SW, Kim MJ, Yoon SH, Rhie DJ

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):337-343.
  • doi: 10.4196/kjpp.2010.14.5.337
Long-term potentiation (LTP) and long-term depression (LTD) have both been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. In a previous study, we suggested that a...
CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1alpha in Hepatoma Cells

Lee KH

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):331-336.
  • doi: 10.4196/kjpp.2010.14.5.331
In rapidly growing tumors, hypoxia commonly develops due to the imbalance between O2 consumption and supply. Hypoxia Inducible Factor (HIF)-1alpha is a transcription factor responsible for tumor growth and angiogenesis...
Epigallocatechin-3-gallate Regulates NADPH Oxidase Expression in Human Umbilical Vein Endothelial Cells

Ahn HY, Kim CH, Ha TS

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):325-329.
  • doi: 10.4196/kjpp.2010.14.5.325
Vascular NADPH oxidase plays a pivotal role in producing superoxide in endothelial cells and thus acts in the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate (EGCG),...
Regional Distribution of Interstitial Cells of Cajal, (ICC) in Human Stomach

Yun HY, Sung R, Kim YC, Choi W, Kim HS, Kim H, Lee GJ, You RY, Park SM, Yun SJ, Kim MJ, Kim WS, Song YJ, Xu WX, Lee SJ

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):317-324.
  • doi: 10.4196/kjpp.2010.14.5.317
We elucidated the distribution of interstitial cells of Cajal (ICC) in human stomach, using cryosection and c-Kit immunohistochemistry to identify c-Kit positive ICC. Before c-Kit staining, we routinely used hematoxylin...
P2X and P2Y Receptors Mediate Contraction Induced by Electrical Field Stimulation in Feline Esophageal Smooth Muscle

Cho YR, Jang HS, Kim W, Park SY, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):311-316.
  • doi: 10.4196/kjpp.2010.14.5.311
It is well-known that electrical field stimulation (EFS)-induced contraction is mediated by a cholinergic mechanism and other neurotransmitters. NO, ATP, calcitonin gene-related peptide (CGRP), and substance P are released by...
Response of I(Kr) and hERG Currents to the Antipsychotics Tiapride and Sulpiride

Jo SH, Lee SY

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):305-310.
  • doi: 10.4196/kjpp.2010.14.5.305
The human ether-a-go-go-related gene (hERG) channel is important for repolarization in human myocardium and is a common target for drugs that prolong the QT interval. We studied the effects of...
Losartan Inhibits Vascular Smooth Muscle Cell Proliferation through Activation of AMP-Activated Protein Kinase

Kim JE, Choi HC

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):299-304.
  • doi: 10.4196/kjpp.2010.14.5.299
Losartan is a selective angiotensin II (Ang II) type 1 (AT1) receptor antagonist which inhibits vascular smooth muscle cells (VSMCs) contraction and proliferation. We hypothesized that losartan may prevent cell...
Effects of Isoflurane Anesthesia on Post-Anesthetic Sleep-Wake Architectures in Rats

Jang HS, Jung JY, Jang KH, Lee MG

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):291-297.
  • doi: 10.4196/kjpp.2010.14.5.291
The sleep homeostatic response significantly affects the state of anesthesia. In addition, sleep recovery may occur during anesthesia, either via a natural sleep-like process to occur or via a direct...
Antinociception Effect and Mechanisms of Campanula Punctata Extract in the Mouse

Park SH, Sim YB, Lim SS, Kim JK, Lee JK, Suh HW

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):285-289.
  • doi: 10.4196/kjpp.2010.14.5.285
In the present study, the antinociceptive profiles of Campanula punctata extract were examined in ICR mice. The Campanula punctata contain a large dose of saponin. Campanula punctata extract administered orally...
Bark Constituents from Mushroom-detoxified Rhus verniciflua Suppress Kainic Acid-induced Neuronal Cell Death in Mouse Hippocampus

Byun JS, Han YH, Hong SJ, Hwang SM, Kwon YS, Lee HJ, Kim SS, Kim MJ, Chun W

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):279-283.
  • doi: 10.4196/kjpp.2010.14.5.279
Urushinol, a plant allergen, has significantly restricted the medical application of Rhus verniciflua, although it has been reported to possess a wide variety of biological activities such as anti-inflammatory, antioxidant,...
Effect of the Heat-exposure on Peripheral Sudomotor Activity Including the Density of Active Sweat Glands and Single Sweat Gland Output

Lee JB, Kim TW, Shin YO, Min YK, Yang HM

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):273-278.
  • doi: 10.4196/kjpp.2010.14.5.273
Tropical inhabitants are able to tolerate heat through permanent residence in hot and often humid tropical climates. The goal of this study was to clarify the peripheral mechanisms involved in...
Identification of Differentially Expressed Genes in Bovine Follicular Cystic Ovaries

Choe C, Cho YW, Kim CW, Son DS, Han J, Kang D

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):265-272.
  • doi: 10.4196/kjpp.2010.14.5.265
Follicular cystic ovary (FCO) is one of the most frequently diagnosed ovarian diseases and is a major cause of reproductive failure in mammalian species. However, the mechanism by which FCO...
Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus

Kwon MS, Lee JK, Park SH, Sim YB, Jung JS, Won MH, Kim SM, Suh HW

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):257-263.
  • doi: 10.4196/kjpp.2010.14.5.257
Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g][1]-benzopyran-5-one), which is an active principle extracted from the fruits of Ammi visnaga, has been used as a treatment for low blood-pressure and blocked blood vessel contraction by inhibition...
Gender-Related Differences in a Process of the Age-Dependent Alterations of the Elements in Monkey Sino-Atrial Node

Satoh H, Tohno S, Minami T, Oishi T, Hayashi M, Tohno Y

  • Korean J Physiol Pharmacol.
  • 2010 Oct;14(5):249-256.
  • doi: 10.4196/kjpp.2010.14.5.249
Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30...

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