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8 results

Calcium Sensitization Induced by Sodium Fluoride in Permeabilized Rat Mesenteric Arteries

Yang E, Cho JY, Sohn UD, Kim IK

  • Korean J Physiol Pharmacol.
  • 2010 Feb;14(1):51-57.
  • doi: 10.4196/kjpp.2010.14.1.51
It was hypothesized that NaF induces calcium sensitization in Ca2+-controlled solution in permeabilized rat mesenteric arteries. Rat mesenteric arteries were permeabilized with beta-escin and subjected to tension measurement. NaF potentiated...
R-type Calcium Channel Isoform in Rat Dorsal Root Ganglion Neurons

Fang Z, Hwang JH, Kim JS, Jung SJ, Oh SB

  • Korean J Physiol Pharmacol.
  • 2010 Feb;14(1):45-49.
  • doi: 10.4196/kjpp.2010.14.1.45
R-type Cav2.3 high voltage-activated Ca2+ channels in peripheral sensory neurons contribute to pain transmission. Recently we have demonstrated that, among the six Cav2.3 isoforms (Cav2.3a~Cav2.3e), the Cav2.3e isoform is primarily...
Inhibition of eNOS/sGC/PKG Pathway Decreases Akt Phosphorylation Induced by Kainic Acid in Mouse Hippocampus

Lee SH, Byun JS, Kong PJ, Lee HJ, Kim DK, Kim HS, Sohn JH, Lee JJ, Lim SY, Chun W, Kim SS

  • Korean J Physiol Pharmacol.
  • 2010 Feb;14(1):37-43.
  • doi: 10.4196/kjpp.2010.14.1.37
The serine/threonine kinase Akt has been shown to play a role of multiple cellular signaling pathways and act as a transducer of many functions initiated by growth factor receptors that...
MLCK and PKC Involvements via Gi and Rho A Protein in Contraction by the Electrical Field Stimulation in Feline Esophageal Smooth Muscle

Park SY, Shim JH, Kim M, Sun YH, Kwak HS, Yan X, Choi BC, Im C, Sim SS, Jeong JH, Kim IK, Min YS, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2010 Feb;14(1):29-35.
  • doi: 10.4196/kjpp.2010.14.1.29
We have shown that myosin light chain kinase (MLCK) was required for the off-contraction in response to the electrical field stimulation (EFS) of feline esophageal smooth muscle. In this study,...
Octyl Gallate Inhibits ATP-induced Intracellular Calcium Increase in PC12 Cells by Inhibiting Multiple Pathways

Guo Y, Hong YJ, Jang HJ, Kim MJ, Rhie DJ, Jo YH, Hahn SJ, Yoon SH

  • Korean J Physiol Pharmacol.
  • 2010 Feb;14(1):21-28.
  • doi: 10.4196/kjpp.2010.14.1.21
Phenolic compounds affect intracellular free Ca2+ concentration ([Ca2+]i) signaling. The study examined whether the simple phenolic compound octyl gallate affects ATP-induced Ca2+ signaling in PC12 cells using fura-2-based digital Ca2+...
Effect of Modulation of hnRNP L Levels on the Decay of bcl-2 mRNA in MCF-7 Cells

Lim MH, Lee DH, Jung SE, Youn DY, Park CS, Lee JH

  • Korean J Physiol Pharmacol.
  • 2010 Feb;14(1):15-20.
  • doi: 10.4196/kjpp.2010.14.1.15
It has been shown that CA repeats in the 3'-untranslated region (UTR) of bcl-2 mRNA contribute the constitutive decay of bcl-2 mRNA and that hnRNP L (heterogenous nuclear ribonucleoprotein L)...
Dendritic Cells-based Vaccine and Immune Monitoring for Hepatocellular Carcinoma

Lee DH

  • Korean J Physiol Pharmacol.
  • 2010 Feb;14(1):11-14.
  • doi: 10.4196/kjpp.2010.14.1.11
Human tumors, including those of the hepatobiliary system, express a number of specific antigens that can be recognized by T cells, and may provide potential targets for cancer immunotherapy. Dendritic...
Mechanical Stretch-Induced Protection against Myocardial Ischemia-Reperfusion Injury Involves AMP-Activated Protein Kinase

Hao J, Kim HS, Choi W, Ha TS, Ahn HY, Kim CH

  • Korean J Physiol Pharmacol.
  • 2010 Feb;14(1):1-9.
  • doi: 10.4196/kjpp.2010.14.1.1
AMP-activated protein kinase (AMPK) protects various tissues and cells from ischemic insults and is activated by many stimuli including mechanical stretch. Therefore, this study investigated if the activation of AMPK...

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