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Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells

Kim YJ, Kim EA, Sohn UD, Yim CB, Im C

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):441-447.
  • doi: 10.4196/kjpp.2010.14.6.441
B13, a ceramide analogue, is a ceramidase inhibitor and induces apoptosis to give potent anticancer activity. A series of thiourea B13 analogues was evaluated for their in vitro cytotoxic activities...
Neuroprotection by Valproic Acid in Mouse Models of Permanent and Transient Focal Cerebral Ischemia

Qian YR, Lee MJ, Hwang S, Kook JH, Kim JK, Bae CS

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):435-440.
  • doi: 10.4196/kjpp.2010.14.6.435
Valproic acid (VPA) is a well-known anti-epileptic and mood stabilizing drug. A growing number of reports demonstrate that VPA is neuroprotective against various insults. Despite intensive efforts to develop new...
Effect of Extremely Low Frequency Electromagnetic Fields (EMF) on Phospholipase Activity in the Cultured Cells

Song HS, Kim HR, Ko MS, Jeong JM, Kim YH, Kim MC, Hwang YH, Sohn UD, Gimm YM, Myung SH, Sim SS

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):427-433.
  • doi: 10.4196/kjpp.2010.14.6.427
This study was conducted to investigate the effects of extremely low frequency electromagnetic fields (EMF) on signal pathway in plasma membrane of cultured cells (RAW 264.7 cells and RBL 2H3...
Functional Expression of TRPV4 Cation Channels in Human Mast Cell Line (HMC-1)

Kim KS, Shin DH, Nam JH, Park KS, Zhang YH, Kim WK, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):419-425.
  • doi: 10.4196/kjpp.2010.14.6.419
Mast cells are activated by specific allergens and also by various nonspecific stimuli, which might induce physical urticaria. This study investigated the functional expression of temperature sensitive transient receptor potential...
The Role of the Pattern Edge in Goldfish Visual Motion Detection

Kim SH, Jung CS

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):413-417.
  • doi: 10.4196/kjpp.2010.14.6.413
To understand the function of edges in perception of moving objects, we defined four questions to answer. Is the focus point in visual motion detection of a moving object: (1)...
Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells

Lee SY, Ko KW, Kang WK, Choe YJ, Kim YH, Kim IK, Kim J, Kim HS

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):407-412.
  • doi: 10.4196/kjpp.2010.14.6.407
3-Deazaadenosine (DZA), a potent inhibitor of S-adenosylhomocysteine hydrolase, was previously proposed to induce intrinsic apoptosis in human leukemic cells. In the present study, we analyzed the mechanism underlying the DZA-induced...
The Development of Phasic and Tonic Inhibition in the Rat Visual Cortex

Jang HJ, Cho KH, Park SW, Kim MJ, Yoon SH, Rhie DJ

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):399-405.
  • doi: 10.4196/kjpp.2010.14.6.399
Gamma-aminobutyric acid (GABA)-ergic inhibition is important in the function of the visual cortex. In a previous study, we reported a developmental increase in GABAA receptor-mediated inhibition in the rat visual...
Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species

Kim KC, Lee C

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):391-397.
  • doi: 10.4196/kjpp.2010.14.6.391
E2F transcription factors and their target genes have been known to play an important role in cell growth control. We found that curcumin, a polyphenolic phytochemical isolated from the plant...
Plasminogen Activator Inhibitor-1 Antisense Oligodeoxynucleotides Abrogate Mesangial Fibronectin Accumulation

Park J, Seo JY, Ha H

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):385-390.
  • doi: 10.4196/kjpp.2010.14.6.385
Excessive extracellular matrix (ECM) accumulation is the main feature of chronic renal disease including diabetic nephropathy. Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM...
Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice

Cha HN, Choi JH, Kim YW, Kim JY, Ahn MW, Park SY

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):377-384.
  • doi: 10.4196/kjpp.2010.14.6.377
The present study examined whether metformin treatment prevents isoporterenol-induced cardiac hypertrophy in mice. Chronic subcutaneous infusion of isoproterenol (15 mg/kg/24 h) for 1 week using an osmotic minipump induced cardiac...
Effects of Glycyrrhizae Radix on Repeated Restraint Stress-induced Neurochemical and Behavioral Responses

Park HJ, Shim HS, Kim H, Kim KS, Lee H, Hahm DH, Shim I

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):371-376.
  • doi: 10.4196/kjpp.2010.14.6.371
Glycyrrhizae radix (GR) is an herbal medicine that is commonly used in the East Asia for treating a variety of diseases, including stomach disorders. The objective of the present study...
Melatonin Induces Apoptotic Cell Death via p53 in LNCaP Cells

Kim CH, Yoo YM

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):365-369.
  • doi: 10.4196/kjpp.2010.14.6.365
In this study, we examined whether melatonin promotes apoptotic cell death via p53 in prostate LNCaP cells. Melatonin treatment significantly curtailed the growth of LNCaP cells in a dose- and...
Sigma-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in Rats

Son JS, Kwon YB

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):359-364.
  • doi: 10.4196/kjpp.2010.14.6.359
Many therapeutic roles have been proposed for sigma-1 receptor (Sig-1R), but the involvement of Sig-1R in neuropathic pain has currently not been well explored. The present study aimed to evaluate...
Magnolol Inhibits LPS-induced NF-kappaB/Rel Activation by Blocking p38 Kinase in Murine Macrophages

Li MH, Kothandan , Cho SJ, Huong PT, Nan YH, Lee KY, Shin SY, Yea SS, Jeon YJ

  • Korean J Physiol Pharmacol.
  • 2010 Dec;14(6):353-358.
  • doi: 10.4196/kjpp.2010.14.6.353
This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit LPS-induced expression of iNOS gene and activation of NF-kappaB/Rel in RAW 264.7 cells....

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