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Effects of Saccharin Intake on Hippocampal and Cortical Plasticity in Juvenile and Adolescent Rats

Park JS, Yoo SB, Kim JY, Lee SJ, Oh SB, Kim JS, Lee JH, Park K, Jahng JW, Choi SY

  • Korean J Physiol Pharmacol.
  • 2010 Apr;14(2):113-118.
  • doi: 10.4196/kjpp.2010.14.2.113
The sensory system is developed and optimized by experiences given in the early phase of life in association with other regions of the nervous system. To date, many studies have...
Caffeine and 2-Aminoethoxydiphenyl Borate (2-APB) Have Different Ability to Inhibit Intracellular Calcium Mobilization in Pancreatic Acinar Cell

Choi KJ, Kim KS, Kim SH, Kim DK, Park HS

  • Korean J Physiol Pharmacol.
  • 2010 Apr;14(2):105-111.
  • doi: 10.4196/kjpp.2010.14.2.105
Inositol 1,4,5-trisphosphate receptors (InsP3Rs) modulate Ca2+ release from intracellular Ca2+ store and are extensively expressed in the membrane of endoplasmic/sarcoplasmic reticulum and Golgi. Although caffeine and 2-aminoethoxydiphenyl borate (2-APB) have...
Differential Expression of Metabolism-related Genes in Liver of Diabetic Obese Rats

Seo E, Park EJ, Park MK, Kim DK, Lee HJ, Hong SH

  • Korean J Physiol Pharmacol.
  • 2010 Apr;14(2):99-103.
  • doi: 10.4196/kjpp.2010.14.2.99
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a model of spontaneous type 2 diabetes (T2D), develops hyperglycemic obesity with hyperinsulinemia and insulin resistance after the age of 25 weeks, similar...
Pyrithione-zinc Prevents UVB-induced Epidermal Hyperplasia by Inducing HIF-1alpha

Cho YS, Lee KH, Park JW

  • Korean J Physiol Pharmacol.
  • 2010 Apr;14(2):91-97.
  • doi: 10.4196/kjpp.2010.14.2.91
Epidermal keratinocytes overgrow in response to ultraviolet-B (UVB), which may be associated with skin photoaging and cancer development. Recently, we found that HIF-1alpha controls the keratinocyte cell cycle and thereby...
The Inhibitory Effects of Hydrogen Sulfide on Pacemaker Activity of Interstitial Cells of Cajal from Mouse Small Intestine

Parajuli S, Choi S, Lee J, Kim YD, Park CG, Kim MY, Kim HI, Yeum CH, Jun JY

  • Korean J Physiol Pharmacol.
  • 2010 Apr;14(2):83-89.
  • doi: 10.4196/kjpp.2010.14.2.83
In this study, we studied whether hydrogen sulfide (H2S) has an effect on the pacemaker activity of interstitial cells of Cajal (ICC), in the small intestine of mice. The actions...
Fenofibrate Reduces Age-related Hypercholesterolemia in Normal Rats on a Standard Diet

Han Y, Do MH, Kim MS, Seo E, Park MK, Kim DK, Lee HJ, Seo SY

  • Korean J Physiol Pharmacol.
  • 2010 Apr;14(2):77-81.
  • doi: 10.4196/kjpp.2010.14.2.77
Plasma cholesterol is increased in normal aging in both rodents and humans. This is associated with reduced elimination of cholesterol and decreased receptor-mediated clearance of plasma low-density lipoprotein (LDL) cholesterol....
Intestinal Absorption of Fibrinolytic and Proteolytic Lumbrokinase Extracted from Earthworm, Eisenia andrei

Yan XM, Kim CH, Lee CK, Shin JS, Cho IH, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2010 Apr;14(2):71-75.
  • doi: 10.4196/kjpp.2010.14.2.71
To investigate the intestinal absorption of a fibrinolytic and proteolytic lumbrokinase extracted from Eisenia andrei, we used rat everted gut sacs and an in situ closed-loop recirculation method. We extracted...
Are Spinal GABAergic Elements Related to the Manifestation of Neuropathic Pain in Rat?

Lee J, Back SK, Lim EJ, Cho GC, Kim MA, Kim HJ, Lee MH, Na HS

  • Korean J Physiol Pharmacol.
  • 2010 Apr;14(2):59-69.
  • doi: 10.4196/kjpp.2010.14.2.59
Impairment in spinal inhibition caused by quantitative alteration of GABAergic elements following peripheral nerve injury has been postulated to mediate neuropathic pain. In the present study, we tested whether neuropathic...

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